*+,-./01/&2,+3456/&702+4-8/&2&,45951:-;-&.
/4-;5</&2&8;5:5
*+,-./01/&2,+3456/&702+4-8/&2&,45951:-;-&./4-;5</&
u djece
8+:=84=<:=&>264/9./&?5@+953-AB 4/1-A1
!"#$%&'(#)%#(*+,*-#.#/0+&+12.&1-#32'4%2'5'6.*-7#82'4%2'5'9:.#;%:-52+2#8&+-,.5.92%#-#$%60+<-
!"#$%&'$()$* !+* ,-.$/$0$* ,$* "-1&.$0($*
+1-#$2$* 30+-#&,$* &4$* 2-0)&* .$#&-!"$"!.&*
+5&($.* -,* !&!"64!.6* 789:* ;5&($.* )6* )-<*
2-0)&*+*.-42&($=&)&*!*1#$'&0(&4*&*#6,-'&-
"&4*56".$()64*1$!"-4*/$*/+26*.-)$*!$,#%&*
30+-#*7>9:*?0+-#&,&*&4$)+*'&<6*.$#&-!"$"!.&@*
46@$(&/$4$A*$*(6.&*-,*()&@*!+B*#64&(6#-
$0&/$=&)$*=$.0&(6*+/*4&)6()$()6*46"$2-0&/-
4$*2$."6#&)$A*+($1#6C&'$()6*7+2#/$'$()69*
#64&(6#$0&/$=&)!.&@* 1#-=6!$* .$#&)6!(6*
06/&)6A*6(/&4!.$*&(@&2&=&)$*+(+"$#*10$.$*"&-
)6.-4*D0&.-0&/6*7#6,+.=&)$*!"'$#$()$*.&!6-
M0&.$*8:*K6("$0($*30+-#-/$
M0&.$*F:*?0+-#&,(&*0$.*Z&30+-#&,*8>
M0&.$*L:*?0+-#&,(&*0$.*K+#$1@$"
0&($9A* -46"$()6* !&("6/6* &("#$E* &* 6.!"#$=6-
0+0$#(&@* 1-0&!$@$#&,$* "6* 2$."6#&-!"$"!.&*
+5&($.*7F9:*G&/&.*-,*1-)$'6*,6("$0(6*30+--
#-/6* .-,* (6.6* ,)6=6* ($)56<H6* )6* +/#-.--
'$(*.-#&<"6()64*30+-#&,(&@*($,-4)6!"$.$*
1#'&@* I* D-,&($* !"$#-!"&* ,)6"6"$* 7J9:* K6(-
"$0($* 30+-#-/$* ($!"$)6* .$-* /2#-)* .+4+0$-
"&'(-D* +(-!$* 30+-#$* /$* '#&)646* #$/'-)$*
=$.0&(6*&*-'&!&*-*()6D-'-)*.-0&5&(&A*"#$)$()+*
&*'#646(+*+(-!$*7L9*7!0&.$*89:* /D06,*=$.-
0&(6*.-,*30+-#-/6*4-%6*'$#&#$"&*-,*2&)606*
2-)6* =$.0&(6* .-,* 20$D6* 3-#46* 30+-#-/6*
M0&.$*>:*Y10&.$=&)$*30+-#&,(-D*0$.$
M0&.$*J:*[0&=6*/$*30+-#&,$=&)+*D60-4
1$*,-*%+"-E!46C&@*&0&*5$.*!46C&@*,&!.-0-
-#$=&)$* .-,* )$5&@* -20&.$:* ;/* )$.6* -20&.6*
30+-#-/6*4-%6*!6*($H&*&*)$.-*1#-4&)6()6($*
4-#3-0-D&)$*.#+(6*/+2$:
M* -2/&#-4* ($* '#&)646* ($!"$(.$* ,&)6-
0&4-*,6("$0(+*30+-#-/+*+*"#&*D#+16B
8:* D#+1+*5&(6*,)6=$*-,*NEJ*D-,&(6:*O-,*
()&@*)6*1#&!+"$(*#&/&.*,6("$0(6*30+-#-/6*
"#$)(&@* &(=&/&'$* &* 1#'&@* 4-0$#$* /2-D*
.$0=&3&.$=&)6*&*4$"+#$=&)6*.-)6*!6*-,-
'&)$)+*+*"-)*,-2&:*P#&)646*&/46C+*8L:*
&*FN:*4)6!6=$*%&'-"$*)6*($)#&/&5(&)&*16-
#&-,*7I9:*Q$*"-*'#&)646*"#62$*1$%0)&'-*
.-("#-0&#$"&*&*2$0$(!&#$"&*+(-!*30+-#&,$*
+*-#D$(&/$4*/2-D*1-"#626*1#6'6(=&)6*
#$(-D*,)65)6D*.$#&)6!$:
>:* D#+1+*5&(6*,)6=$*-,*JEI*D-,&($:*?0+-
-#-/$*/$@'$H$*!"#$%()6*/+26*71#64--
0$#&* &* ,#+D&* 4-0$#&9* )6#* !6* /$* "-* '#&-
)646*-,'&)$*.$0=&3&.$=&)$*&*4$"+#$=&)$*
=$.0&(6*"&@*/+2&:
F:* D#+1+*5&(6*,)6=$*-,*I*D-,&($*($,$0)6*
.-,* .-)&@* )6* 4$0&* #&/&.* -,* ,6("$0(6*
30+-#-/6A*-!&4*($*"#6H&4*4-0$#&4$:
Fluoridni lakovi, vodice za
ispiranje i gelovi
R#-36!&-($0($*$10&.$=&)$*"-1&.$0(&@*30+-
-#&,$*)6*63&.$!($*+*#6,+.=&)&*.$#&)6!$*.-,*
,)6=6*!#6,()6D*&0&*'&!-.-D*#&/&.$*-,*.$#&)6-
!$*7SATAU9:*>V*($"#&)6'*30+-#&,*7W$?X*U:NNN*
1149A* 8A>FV* /$.&!60)6(&* 3-!3$"(&* 30+-#&,*
7$=&,+0$"6,* 1@-!1@$"6* 30+-#&,6* E* YR?X*
8>:FNN*1149*+*-"-1&(&*&0&*D60+*78NA88A8>9*
&**LV*($"#&)6'*30+-#&,*0$.*7W$?PX*>>:LNN*
1149*78FA8JA8LA8I9*($)56<H6*!6*.-#&!"6*/$*
1#-36!&-($0(+* 30+-#&,$=&)+:* W6.&* 1#-&/-
'-,&* &4$)+* 1#61-#+56(-* '#&)646* "#$-
)$()$* $10&.$=&)6* 4$()6* -,* J* 4&(+"6* $0&*
.-,* '6H&(6* !6* 1#61-#+5$* $10&.$=&)$* -,* J*
4&(+"6*.$-*63&.$!(&)$*7!0&.$*>9*7UA8NA8S9:*
K-,$"($* "6#$1&)$* 30+-#&,$=&)-4* 4-#$*
!6* 1#-'-,&"&* .-,* ,)6=6* '&<6D* #&/&.$* -,*
.$#&)6!$A*+.0)+5+)+H&*,)6=+*!$*!16=&)$0(&4*
1-"#62$4$* -,#%$'$()$* -#$0(-D* /,#$'0)$*
7TA8TA8U9:* R#6'6("&'($* '#&)6,(-!"* 30+--
#&,(&@*0$.-'$*)6*+*()&@-'-4*1#-,+%6(-4*
'#646(+*,)60-'$()$A*,+D-4*-!&D+#$'$()+*
'&!-.6* .-0&5&(6* 30+-#$* +* +!(-)* <+10)&(&* &*
$10&.$=&)&*($*"6<.-*,-!"+1($A*&("6#,6("$0-
SONDA !"#$%$&'()) 21
===1/<3/91/&-&<342C1/&<+18/&DDD *+,-./01/&2,+3456/&702+4-8/&2&,45951:-;-&
./4-;5</&2&8;5:5

($*1-,#+5)$: _$20&=$*8:* !"#$%&'$()$A*1#61-#+.$*&*1#$."&5($*1#&4)6($*30+-#&,(&@*0$.-'$A*'-,&=$*/$*&!1&#$()6*&*D60-'$:*

!"#$%&'$()$A* 1#61-#+.$* &* 1#$."&5($* `+#-16$(*Y#=@&'6!*-3*R$6,&$"#&=*K6("&!"#a*bb*8N*7F9:*>NNU
1#&4)6($* 30+-#&,(&@* 0$.-'$A* '-,&=$* /$*
&!1&#$()6*&*D60-'$*)6*1#&.$/$($*+*"$20&=&*8:

Zubne paste s fluoridima

\&#-.$*+1-"#62$*/+2(&@*1$!"$*/$!0+%($*
)6*/$*!4$()6()6*/+2(-D*.$#&)6!$*+*/$,()&@*
FN*D-,&($:*]6".$()6*/+2&*!*30+-#&,&#$(-4*
/+2(-4* 1$!"-4* )6* &,6$0($* 46"-,$* 5&)6*
)6* .-#&<"6()6* )6,(-!"$'(-A* )63"&(-A* <&#-.-*
)6* #$!1#-!"#$()6(-* &* .+0"+#-0-<.&* 1#&@-
'$"0)&'-* 7>>9:* R-"6(=&)$0($* -1$!(-!"* .-,*
4$06* ,)6=6* .-)$* .-#&!"6* /+2(+* 1$!"+* )6*
4-D+H(-!"*D+"$()$*'6H6*.-0&5&(6*1#61$#$-
"$*&*&/0$D$()6*#&/&.+*-,*,6("$0(6*30+-#-/6*
7>F9:* Q+2($* 1$!"$* !* 30+-#&,&4$* -,D-'-
-#($*)6*/$*TNV*,(6'(-D*+(-!$*30+-#&,$*+*
1#'6*"#&*D-,&(6*%&'-"$*7>J9:*G-,&"60)&*"#6-
2$)+* .-#&!"&"&* .-0&5&(+* 30+-#&,&#$(6* 1$!"6*
'60&5&(6*/#($*D#$<.$*+*'#0-*4$06*,)6=6*"6*
"$.-C6#*$!&!"&#$"&*,)6=&*.-,*1#$()$*/+2$*,-*
S*D-,&(6*%&'-"$*7>N9:*
^6"-,$* 56".$()$* /+2&B* _#$)$()6* 1--
)6,&(-D*56".$()$*4-#$*2&"&*,+%6*-,*)6,(6*
4&(+"6*&*,)6=&*"#62$*,$"&*+1+"6*,$*&!10)+(+*
'&<$.* /+2(6* 1$!"6* &* ,$* &/2)6D$'$)+* &!1&-
#$()6* '-,-4* ($.-(* 56".$()$:* R#61-#+.$*
)6*,$*!6*,)6=&*/+2&*56".$)+*1#&)6*!1$'$()$*
&* 2$#64* )-<* )6,(-4* +* "-.+* ,$($:* _#62$*
&/2)6D$'$"&* )60-* -,4$@* ($.-(* 56".$()$:*
Q+2&* !6* 4-D+* 56".$"&* &0&* 4$(+$0(-* &0&*
606."#&5(-4* 56".&=-4* !* 4$0-4* D0$'-4*
7>N9:*O$,$*!6*/+2($*1$!"$*!*30+-#&,&4$*.--
#&!"&* +* .-42&($=&)&* !* ,#+D&4* 1#61$#$"&4$*
30+-#$A*"#62$*+'&)6.*+/&4$"&*+*-2/&#*.+4+-
0$"&'(&* 636."* 30+-#&,$* /$* ,)6=+* 40$C+* -,*
I*D-,&($:*_#62$*-,#%$'$"&*2$0$(!*&/46C+*
4$.!&4$0(-D*.$#&)6!*1#-"6."&'(-D*636."$*
&* +4$()6()$* #&/&.$* -,* ,6("$0(6* 30+-#-/6*
7>N9:*;*"$20&=&*>*($'6,6(6*!+*1#61-#+56(6*
.-0&5&(6*/+2(6*1$!"6*+*,)6=6:

_$20&=$*>:*R#61-#+56($*.-0&5&($*/+2(6*1$!"6*+*,)6=6*7>N9:

22 !"#$%$&'()) SONDA
 *+,-./01/&2,+3456/&702+4-8/&2&,45951:-;-&./4-;5</&2&8;5:5
LITERATURA
1. Featherstone JD. Prevention and rever-
sal of dental caries: role of low level
fluoride. Community Dent Oral Epidemiol
1999;27:31-40.
2. Rolla G, Ogaard, Cruz RDA. Clinical effect
and mechanism of cariostatic action of
fluoride- containing toothpastes: a review.
Int Dent J 1991
3. Featherstone JD. The science and practice
of caries pre-vention. J Am Dent Assoc
2000;131(7):877-99.
4. !"#$%&'()&*#+,-.#/&001&2%34/$,-&!355%--
ments and fluorosis: a meta-analysis.
Community Dent Oral Epidemiol
1999;27:48-56.
5. CDC. Recommendations for using fluoride
to prevent and control dental caries in
the United States. MMWR Recomm Rep
2001;50(RR-14): 1-42.
6. Evans RW, Stamm JW. An epidemiologic
estimate of the critical period during
which human maxillary central incisors
are most susceptible to fluorosis. J Public
Health Dent 1991;51:251-599.
7. Facts about fluoride. CDS Rev
2006;99(1):44.
8. American Dental Association Council on
Scientific Af-fairs. Professionally-applied
topical fluoride: Evidence-based clini-
cal recommendations. J Am Dent Assoc
2006;137(8):1151-9.
9. CDC. Achievements in Public Health,
1990-1999: Fluo¬ridation of drinking
M0&.$*I:*c60*/$*30+-#&,$=&)+ water to prevent dental caries. JAMA
2000;283(10):1283-6.
10. Adair SM. Evidence-based use of fluoride
in con- temporary pediatric dental prac-
tice. Pediatr Dent 2006:28(2):133-42.
11. Rozier RG. Effectiveness of methods used
by dental professionals for the primary
prevention of dental caries. J Dent Educ
2001;65(10):1063-72.
12. Marinho V. Fluoride gel inhibits caries in
children who have low caries-risk but this
may not be clinically relevant. Evid Based
Dent 2004;5(4):95.
13. Marinho VC, Higgins JP, Sheiham A, Logan
S. Com¬binations of topical fluoride
(toothpastes, mouthrinses, gels, var-
nishes) versus single topical fluoride for
prevent-ing dental caries in children and
adolescents. Cochrane Data-base Syst Rev
2004(1):CD002781.
14. Marinho VC, Higgins JP, Logan S, Sheiham
A. Fluoride gels for preventing dental car-
ies in children and adoles-cents. Cochrane
Database Syst Rev 2002(2):CD002280.
15. Bawden JW. Fluoride varnish: A useful new
tool for public health dentistry. J Public
Health Dent 1998;58(4):266-9.
16. Wei SH, Hattab FN. Fluoride retention
following topicalapplication of a new APF
foam. Pediatr Dent 1989;11(2):121-4.
17. Axelsson S, Soder B, Nordenram G, et
al. Effect of combined caries-preventive
methods: A systematic review of con-
trolled clinical trials. Acta Odontol Scand
2004;62(3):163-9.
18. American Academy of Pediatric Dentistry.
Policy on use of a caries-risk assess-
ment tool (CAT) for infants, children, and
adolescents. Pediatr Dent 2006;28(sup-
pl):24-8.
19. European Archives of Paediatric Dentistry
// 10 (3). 2009; 131-34.
20. Scottish Intercollegiate Guidelines
Network. Prevention and management
of dental decay in the pre-school child.
A national clinical guideline. No. 83. In,
2005: 44.
21. Burt BA. Prevention policies in the light of
the changed distribution of dental caries.
Acta Odontol Scand 1998;56:583-591.
22. Mascarenhas AK, Burt BA. Fluorosis risk
from early exposure
23. to fluoride toothpaste. Community Dent
Oral Epidemiol 1998;26:241-248.
24. de Almeida BS, da Silva Cardoso VE, Bu-
zalaf MAR. Fluoride ingestion from tooth-
paste and diet in 1- to 3-year-old Brazilian
children. Community Dent Oral Epidemiol
2007;35:53-63.
SONDA !"#$%$&'()) 23