Struggling with writing a dissertation on GM-CSF? You're not alone.

Crafting a dissertation can be

an arduous task, especially when dealing with complex subjects like GM-CSF. From extensive
research to meticulous writing and formatting, the process demands time, dedication, and expertise.

The intricacies of the GM-CSF topic require a deep understanding of the subject matter, along with
the ability to critically analyze data and literature. Moreover, adhering to academic standards and
guidelines adds another layer of complexity to the task.

If you find yourself overwhelmed by the challenges of writing your GM-CSF dissertation, fear not.
Help is available. At ⇒ HelpWriting.net ⇔, we specialize in providing expert assistance to students
tackling intricate academic projects like dissertations.

Our team comprises experienced writers with advanced degrees in relevant fields, ensuring that your
dissertation receives the attention it deserves. Whether you need help with research, writing, editing,
or formatting, we've got you covered.

By entrusting your GM-CSF dissertation to ⇒ HelpWriting.net ⇔, you can rest assured that you'll
receive a high-quality, custom-written document that meets your requirements and exceeds your
expectations. We understand the importance of deadlines and strive to deliver impeccable work
within the agreed-upon timeframe.

Don't let the daunting nature of dissertation writing hold you back. Instead, leverage the expertise of
our team at ⇒ HelpWriting.net ⇔ and embark on the path to academic success. Place your order
today and take the first step towards completing your GM-CSF dissertation with confidence.
Baseline clinical and demographic features were similar in the two groups ( table 1 ). Circulating
cytokine concentrations are shown in the online data supplement, figure S2. This cohort included a
broad spectrum of patients with causes for admission representative of ICU case mixes. The small
sample size also probably explains the unexpected imbalance in mean neutrophil phagocytosis at
baseline. GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing.
Development of molecularly cloned G CSF and GM CSF has increased the safety and efficacy of
intensive chemotherapy and radiation therapy in order to reverse damage to bone marrow function.
Circulatory shock Cardiogenic Shock Hypovolemic Shock Sepsis, Septic Shock an. For the primary
outcome measure, there were two missing values. Work-role of Radiation Therapists in the
Consequences of Adaptive Radiotherap. Secondary outcomes included neutrophil phagocytosis over
time, neutrophil functions other than phagocytosis, monocyte HLA-DR expression and safety.
Remember ! There is more to Cytology than meets the Eye. It reduces the infections, bleeding and
shortening hospitalization. This study tested the hypothesis that GM-CSF improves neutrophil
phagocytosis in critically ill patients in whom phagocytosis is known to be impaired. These cookies
help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Neutrophils were isolated from whole blood on day 2 as described in the Methods. However we are
unaware of any possibility that laboratory staff could have been unblinded in performing and
reporting neutrophil assays. Fever was the most common adverse event recorded (four in the GM-
CSF group, none in the placebo group). Moreover, GM CSF receptors are more widely expressed
than G CSF receptors. Fungal infections. Cryptococcal meningitis (AIDS) Candida meningitis
(neonates and neurosurgery) Brain abscesses. Based on our previous studies, we had not anticipated
the rate of recovery in mean phagocytosis observed in the placebo group ( figure 3A ). GM CSF has
much broader effects on multiple cell lineages, especially on macrophages and eosinophils. These
cookies ensure basic functionalities and security features of the website, anonymously. Enhanced
neutrophil phagocytosis and the striking improvement in monocyte HLA-DR ( figure 4 ) suggest
combined beneficial immunomodulatory effects for GM-CSF in vivo. Bonferroni’s post hoc
correction was used as an informal guide to assess significance or otherwise of the resulting p values.
For panel (A) statistical comparison of area under the curve for each group used the linear
trapezoidal rule by summing the areas between each time point. A further limitation relates to the
number of patients screened relative to the number recruited ( figure 1 ). Similarly we observed no
effect of GM-CSF on apoptosis, chemotaxis or extracellular superoxide generation ( figure 3 ).
Sampling schedule Whole blood was drawn at baseline (pretreatment), then daily through to day 9
for safety analysis. Therefore, unbound drug concentrations in human cerebrospinal fluid (CSF) are
used as a surrogate for human brainECF concentrations. All flow cytometry was carried out using a
FACSCanto II flow cytometer (Becton Dickinson).
It is the most widely used molecularly cloned hematopoietic growth factor. Neutrophils were
isolated from whole blood on day 2 as described in the Methods. Life-threatening problems with
high associated mortality and morbidity Presentation may be acute, subacute, or chronic Clinical
findings determined by anatomic site(s) of involvement, infecting pathogen, and host response.
However, we believe that the apparent significant differences in the proportion of patients with
phagocytosis ?50% suggest an important biological effect of GM-CSF on neutrophil phagocytosis in
a subset of patients ( table 2 ). Indeed, GM-CSF increases phagocytosis in vitro regardless of
baseline levels. For panels (B), (C) and (D) statistical analysis used analysis of covariance
(ANCOVA) methods. In the results that follow, the data are presented with adjustment for baseline
phagocytosis and site. Medulloblastoma 35. Retinoblastoma and ?pinealoblastoma 36. Remember !
There is more to Cytology than meets the Eye. THE MENINGES. 3 Layers: Dura mater, Arachnoid
mater and Pia mater. The study’s statistical analysis plan is found at the end of the online
supplemental data section. These cookies track visitors across websites and collect information to
provide customized ads. No suspected unexpected serious adverse reactions (SUSARs) were
reported. She has more than eight years of research experience in the fields of beneficial soil
microorganisms and Biofertilizers. Report Back from San Antonio Breast Cancer Symposium
(SABCS) 2023: Spotlight. Finally, the assay used to test neutrophil phagocytosis has the limitation
that it is labour-intensive and operator-dependent, and its widespread use in hospital laboratories is
hard to envisage. Abnormal Cervical Cytology requiring Colposcopy in Women under Thirty Years i.
Randomisation Patients were randomised 1:1, with stratification by site, using a web-based
randomisation service in the Newcastle Clinical Trials Unit. To that end, systematic studies on the
inter-relationship of plasma PK, blood-brain barrier (BBB) transport, blood-CSF barrier (BCSFB)
transport and intra-brain distribution were performed in the rat by implantation of microdialysis
probes at multiple brain sites in individual animals. Based on our previous studies, we had not
anticipated the rate of recovery in mean phagocytosis observed in the placebo group ( figure 3A ).
Circulatory shock Cardiogenic Shock Hypovolemic Shock Sepsis, Septic Shock an. Bonferroni’s
post-hoc correction was used as an informal guide to assess significance or otherwise of the resulting
p values. Importantly, the assay was chosen specifically because it predicts ICUAI in our hands,
while automated assays have not been shown to do so thus far. Bonferroni’s post-hoc correction was
used as an informal guide to assess significance or otherwise of the resulting p values. Moreover, GM
CSF receptors are more widely expressed than G CSF receptors. Similarly we observed no effect of
GM-CSF on apoptosis, chemotaxis or extracellular superoxide generation ( figure 3 ). You can asses
this ppt for your routine laboratory work. Enhanced neutrophil phagocytosis and the striking
improvement in monocyte HLA-DR ( figure 4 ) suggest combined beneficial immunomodulatory
effects for GM-CSF in vivo. You also have the option to opt-out of these cookies. Shadid Summary -
Neoplasms of infancy and childhood - Asem M.
Conclusions GM-CSF did not improve mean neutrophil phagocytosis at day 2, but was safe and
appeared to increase the proportion of patients with adequate phagocytosis. Circulatory shock
Cardiogenic Shock Hypovolemic Shock Sepsis, Septic Shock an. Of the 17 patients randomised to
GM-CSF, 4 received less than two doses of study drug (1 died before any administration of study
drug and 3 triggered safety criteria for study drug termination (defined in the online supplemental
data section, table S3 ); of these 3, 1 had thrombocytosis before any administration of study drug, 1
developed significant transaminitis after one dose, and 1 developed thrombocytopenia after one
dose). Fever was the most common adverse event recorded (four in the GM-CSF group, none in the
placebo group). One was in the GM-CSF group (intestinal obstruction requiring surgery on day 1,
considered unrelated to study drug) and two in the placebo group (one acute respiratory deterioration
with pneumomediastinum on day 3; one acute respiratory deterioration with type II respiratory
failure on day 4). Medical Microbiology and Immunology Department, Faculty of Medicine,
Mansoura. However this has been countered by data from other studies. 35 36 We found no effect of
GM-CSF on PaO 2:FiO 2 ratios (online supplemental data section, table S7 ). Primary Brain Tumours
Intra operative smears 39. 40. Report on what you see, not what you expect to see. All authors had
access to the primary clinical trial data. The close temporal relationship between GM-CSF
administration and HLA-DR expression provides strong evidence, in our view, that GM-CSF was
absorbed and biologically active. SAEs were recorded but not subjected to formal statistical analysis
beyond tabulation by group. Colposcopy attendance in women with High Grade Lesion of Cervix
and histologi. Moreover, G-CSFR is expressed primarily on neutrophils and bone marrow precursor
cells, while GM-CSFR more widely expressed than the G-CSFR. By day 30, 13 ICUAIs developed
in six separate patients in the placebo group and 9 ICUAIs in seven separate patients in the GM-CSF
group. Adjust therapy based upon specific organism and sensitivities Culture negative. This study
tested the hypothesis that GM-CSF improves neutrophil phagocytosis in critically ill patients in
whom phagocytosis is known to be impaired. Neutrophils were isolated from whole blood on day 2
as described in the Methods. Primary and secondary outcomes were assessed on an intention-to-treat
basis. Other secondary outcomes were examined using the same methods as for the primary end
point. Patients, medical staff, nursing staff providing clinical care and laboratory staff were blinded
to allocation. Fungal infections. Cryptococcal meningitis (AIDS) Candida meningitis (neonates and
neurosurgery) Brain abscesses. His wife relates that he has been very confused today and she called
911 after a seizure. Interobserver variation in the assay among the experienced operators in our lab
was ?1.04% (95% CI ?2.82% to 0.73%). The test was therefore ideal for our purposes but would be
harder to implement in larger studies. First, and most importantly, while we intended this study to be
double-blinded, the retrospective discovery of a potential breach in blinding, related to the recording
of clinical data, resulted in the study being reported as single-blinded. As a consequence the study
may have been underpowered to detect a significant difference in the primary end point. A further
limitation relates to the number of patients screened relative to the number recruited ( figure 1 ).
Seventeen patients were randomised to receive GM-CSF and 21 to receive placebo. It is the most
widely used molecularly cloned hematopoietic growth factor. The consistent direction of effect in the
GM-CSF-treated group supports our cautious conclusion that there is a small but true biological
response of GM-CSF on neutrophil function in vivo. Automated identification of Tuberculosis bacilli
on sputum smears using digi.
GM CSF is a glycoprotein that stimulates the proliferation of granulocytes and macrophages from
bone marrow precursor cells. Shadid Summary - Neoplasms of infancy and childhood - Asem M.
Administration was once daily for 4 days, and injection sites were different every day. As the
missing values are less than 10%, no imputation was carried out. Creating the best possible in vitro
conditions for the embryo, with the use of this cytokine, will promote successful implantation
through improved endometrial receptivity. These cookies help provide information on metrics the
number of visitors, bounce rate, traffic source, etc. Laboratory assays Blood samples were
transported fresh to a single central laboratory (journey time less than 1?hour from each ICU) for
analysis by staff proficient in all of the techniques described below. Neutrophils are the key cellular
effectors in clearance of bacterial and fungal infections. 9 10 Acquired neutrophil dysfunction is
common during critical illness. However this has been countered by data from other studies. 35 36
We found no effect of GM-CSF on PaO 2:FiO 2 ratios (online supplemental data section, table S7 ).
Life-threatening problems with high associated mortality and morbidity Presentation may be acute,
subacute, or chronic Clinical findings determined by anatomic site(s) of involvement, infecting
pathogen, and host response. Abhinav S Work-role of Radiation Therapists in the Consequences of
Adaptive Radiotherap. GM-CSF treatment appeared to be associated with a significant rise in
monocyte HLA-DR at day 2 (p figure 4; the data are shown as individual data points for each time
interval in figure S1 in the online supplemental data section). But opting out of some of these cookies
may affect your browsing experience. Moreover, these drugs are important for hematopoietic cell
transplants. Data with missing observations (other than due to mortality) were examined to determine
both the extent of, and reason for, such omissions. The gene that codes for G CSF is present in
chromosome 17. You also have the option to opt-out of these cookies. GERIATRIC
PHARMACOLOGY Geriatric pharmacology is a specialized field focusing. The incidence of
significant lesions on cervical smears in women under thirty. Details relating to deaths are shown in
the online supplemental data section (table S4). A further limitation relates to the number of patients
screened relative to the number recruited ( figure 1 ). The imbalance in the allocation ratio was due to
the use of block randomisation and stratification. In cases where there were missing data with no
additional data either before or after the missing time point, we did not calculate the area and treated
that patient’s AUC as missing. ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF
ACUTE PULMONARY EMBOLISM.pdf ABDULRAHMAN AL RAFIQ UPDATED
MANAGEMENT OF ACUTE PULMONARY EMBOLISM.pdf Seminario BioMol- Aura Cristina
Pena Santos Seminario BioMol- Aura Cristina Pena Santos Nasal Decongestants.pdf Nasal
Decongestants.pdf MAMMARY GLANDS FINAL.pptx MAMMARY GLANDS FINAL.pptx
Bursitis is inflammation or irritation of a bursa sac. In cases where there were missing data with no
additional data either immediately before or after the missing time point, we did not calculate the
area and treated that patient’s area under the curve as missing. Furthermore, despite the small
difference at baseline, the rate of recovery of neutrophil phagocytosis appears greater over the 4 days
of GM-CSF administration, as evidenced by the steepness of the slopes in figure 3A. GERIATRIC
PHARMACOLOGY Geriatric pharmacology is a specialized field focusing. THE MENINGES. 3
Layers: Dura mater, Arachnoid mater and Pia mater. Clinical and safety outcomes included serial
estimation of sequential organ failure assessment (SOFA) Score, 25 length of stay in ICU, the
incidence of ICUAI, all-cause mortality 30 days postrandomisation, and laboratory analyses
including full blood count, urea and creatinine, and aminotransferases. In summary, this study
supports a beneficial effect of GM-CSF on monocyte HLA-DR, and suggests a beneficial effect on
neutrophil phagocytosis, at least in the proportion of patients responding.
Also note the nature of the clot. - Delicate clot, which resembles a cobweb, is characteristically seen
in tubercular meningitis due to marked increased in CSF proteins. Enhanced neutrophil phagocytosis
and the striking improvement in monocyte HLA-DR ( figure 4 ) suggest combined beneficial
immunomodulatory effects for GM-CSF in vivo. GM CSF is a glycoprotein that stimulates the
proliferation of granulocytes and macrophages from bone marrow precursor cells. Primary Brain
Tumours Intra operative smears 39. 40. Report on what you see, not what you expect to see. You can
asses this ppt for your routine laboratory work. All flow cytometry was carried out using a
FACSCanto II flow cytometer (Becton Dickinson). Mitchell G. ScottRoutine c erebrospinal fluid (
CSF ) a nalysis. No significant differences were apparent in neutrophil apoptosis ( figure 3B ),
neutrophil chemotaxis ( figure 3C ) or superoxide generation ( figure 3D ). It is the most widely used
molecularly cloned hematopoietic growth factor. Data were analysed by TC and TF (study
statisticians). Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight.
Increasing evidence points to the value of identifying treatment-responsive endotypes in clinical
trials. 18 We used a precision medicine approach to target patients with objectively demonstrated
impairment of neutrophil phagocytosis, representing those at highest risk of ICUAI. 11. One was in
the GM-CSF group (intestinal obstruction requiring surgery on day 1, considered unrelated to study
drug) and two in the placebo group (one acute respiratory deterioration with pneumomediastinum on
day 3; one acute respiratory deterioration with type II respiratory failure on day 4). However this has
been countered by data from other studies. 35 36 We found no effect of GM-CSF on PaO 2:FiO 2
ratios (online supplemental data section, table S7 ). The aim of the research presented in this thesis
was to develop a preclinical brain distribution model, allowing the prediction of human brain target
site concentrations on the basis of preclinical data. There was one amendment after the trial
commenced but prior to any patient being randomised. Bacterial infection in CNS may cause:
meningitis, brain abscess, subdural and epidural abscesses empyema. Bursitis is inflammation or
irritation of a bursa sac. NE Hyslop, Jr and MN Swartz, Postgrad Med 58:120, 1975. SAEs were
recorded but not subjected to formal statistical analysis beyond tabulation by group. Furthermore,
despite the small difference at baseline, the rate of recovery of neutrophil phagocytosis appears
greater over the 4 days of GM-CSF administration, as evidenced by the steepness of the slopes in
figure 3A. These cookies ensure basic functionalities and security features of the website,
anonymously. ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE
PULMONARY EMBOLISM.pdf ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT
OF ACUTE PULMONARY EMBOLISM.pdf Seminario BioMol- Aura Cristina Pena Santos
Seminario BioMol- Aura Cristina Pena Santos Nasal Decongestants.pdf Nasal Decongestants.pdf
MAMMARY GLANDS FINAL.pptx MAMMARY GLANDS FINAL.pptx Bursitis is inflammation
or irritation of a bursa sac. Conclusions GM-CSF did not improve mean neutrophil phagocytosis at
day 2, but was safe and appeared to increase the proportion of patients with adequate phagocytosis.
In cases where there were missing data with no additional data either immediately before or after the
missing time point, we did not calculate the area and treated that patient’s area under the curve as
missing. Provenance and peer review Not commissioned; externally peer reviewed. GERIATRIC
PHARMACOLOGY Geriatric pharmacology is a specialized field focusing. Out of these, the
cookies that are categorized as necessary are stored on your browser as they are essential for the
working of basic functionalities of the website. Sargramostim is a molecularly cloned GM CSF and a
glycosylated protein produced in S. Remember ! There is more to Cytology than meets the Eye.
Lymphoid Cells 17. Mixed Inflammatory Infiltrate Camouflage ! 18. When no personal legal
representative was available, written consent was obtained from a professional legal representative,
under the terms of our ethical approval. Neutrophils were isolated from whole blood on day 2 as
described in the Methods. Administration was once daily for 4 days, and injection sites were
different every day. N Engl J Med 2007;357:2431-2440 Kaplan-Meier Survival Estimates According
to Study Group Mai NTH et al. However this has been countered by data from other studies. 35 36
We found no effect of GM-CSF on PaO 2:FiO 2 ratios (online supplemental data section, table S7 ).
The gene that codes for G CSF is present in chromosome 17. Work-role of Radiation Therapists in
the Consequences of Adaptive Radiotherap. Neutrophil functions other than phagocytosis did not
appear significantly different between the groups. To allow for an attrition rate of approximately
10% we proposed a final sample size of 38 patients (19 per group). However, we know of no
biological reason or data to suggest that the effect of GM-CSF on neutrophils should be influenced
by baseline phagocytosis. THE MENINGES. 3 Layers: Dura mater, Arachnoid mater and Pia mater.
Direct measurement of brain extracellular fluid (brainECF) concentrations is highly restricted in
human. Subrata Roy odontogenic keratocyst a developmental cyst odontogenic keratocyst a
developmental cyst Jani253068 Recently uploaded ( 20 ) USG,CT AND MR IMAGING OF
HEPATIC MASS LESIONS. Bonferroni’s post-hoc correction was used as an informal guide to
assess significance or otherwise of the resulting p values. For panel (E) statistical analysis was by
unpaired t-test. Indeed, GM-CSF increases phagocytosis in vitro regardless of baseline levels.
Implantation rate: Number of sacs at week 7 per transferred embryo. Second, the number of patients
recruited was relatively small. As a consequence the study may have been underpowered to detect a
significant difference in the primary end point. In order to be able to build a brain distribution model
understanding of time-dependent (also non-steady state) kinetics of the unbound drug in brainECF
and CSF is essential. No suspected unexpected serious adverse reactions (SUSARs) were reported.
The consistent direction of effect in the GM-CSF-treated group supports our cautious conclusion
that there is a small but true biological response of GM-CSF on neutrophil function in vivo. It is used
to treat patients suffering from certain cancers and neutropenia. This reflected the requirement to
make patient safety the absolute priority in a setting where an investigational medicinal product is
being given to already critically ill patients. Seminario biologia molecular-Universidad Pontificia
Bolivariana. More specifically, G CSF promotes neutrophil proliferation and maturation. Secondary
outcomes included neutrophil phagocytosis over time, neutrophil functions other than phagocytosis,
monocyte HLA-DR expression and safety. This cohort included a broad spectrum of patients with
causes for admission representative of ICU case mixes. Also note the nature of the clot. - Delicate
clot, which resembles a cobweb, is characteristically seen in tubercular meningitis due to marked
increased in CSF proteins.
By day 30, 13 ICUAIs developed in six separate patients in the placebo group and 9 ICUAIs in
seven separate patients in the GM-CSF group. GM-CSF treatment appeared to be associated with a
significant rise in monocyte HLA-DR at day 2 (p figure 4; the data are shown as individual data
points for each time interval in figure S1 in the online supplemental data section). To promptly
recognize the patient with an acute CNS infection syndrome 2. No significant differences were
apparent in neutrophil apoptosis ( figure 3B ), neutrophil chemotaxis ( figure 3C ) or superoxide
generation ( figure 3D ). Conclusions GM-CSF did not improve mean neutrophil phagocytosis at day
2, but was safe and appeared to increase the proportion of patients with adequate phagocytosis. For
panel (A) statistical comparison of area under the curve for each group used the linear trapezoidal
rule by summing the areas between each time point. You also have the option to opt-out of these
cookies. To that end, systematic studies on the inter-relationship of plasma PK, blood-brain barrier
(BBB) transport, blood-CSF barrier (BCSFB) transport and intra-brain distribution were performed
in the rat by implantation of microdialysis probes at multiple brain sites in individual animals. Fever
was the most common adverse event recorded (four in the GM-CSF group, none in the placebo
group). Mixed Plasma cells and Lymphocytes and small round structures with concentric rings 20.
The most common adverse event associated with GM-CSF was fever. Parotid gland cyst Parotid
gland cyst 97 2003 histopath contrasts 97 2003 histopath contrasts Parotid gland cyst Parotid gland
cyst The incidence of significant lesions on cervical poster The incidence of significant lesions on
cervical poster The groot schuur hospital breast clinic abstract smlt 2013 The groot schuur hospital
breast clinic abstract smlt 2013 Abnormal Cervical Cytology requiring Colposcopy in Women under
Thirty Years i. However this has been countered by data from other studies. 35 36 We found no
effect of GM-CSF on PaO 2:FiO 2 ratios (online supplemental data section, table S7 ). All authors
had access to the primary clinical trial data. The aim of the research presented in this thesis was to
develop a preclinical brain distribution model, allowing the prediction of human brain target site
concentrations on the basis of preclinical data. Development of molecularly cloned G CSF and GM
CSF has increased the safety and efficacy of intensive chemotherapy and radiation therapy in order
to reverse damage to bone marrow function. However we are unaware of any possibility that
laboratory staff could have been unblinded in performing and reporting neutrophil assays. After an
audit of data collection, it became apparent that unblinded nursing staff involved in the
administration of the study drug had also undertaken the task of transferring blinded clinical data
from source data to the electronic case report form. Pyogenic Meningitis Aseptic Meningitis
Tuberculous Meningitis Encephalitis Cerebral abscess Cerebral thrombophlebitis. MENINGITIS.
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight. A total of 444
patients meeting the trial inclusion criteria were screened for eligibility. Of the 64 eligible patients
providing consent, 26 were excluded prior to randomisation, of whom 19 were found to have
phagocytic capacity ?50%. GM CSF is a glycoprotein that stimulates the proliferation of
granulocytes and macrophages from bone marrow precursor cells. What is G CSF 3. What is GM
CSF 4. Similarities Between G CSF and GM CSF 5. Adjust therapy based upon specific organism
and sensitivities Culture negative. However, we know of no biological reason or data to suggest that
the effect of GM-CSF on neutrophils should be influenced by baseline phagocytosis. Shadid
Summary - Neoplasms of infancy and childhood - Asem M. G CSF stimulates bone marrow in order
to produce more neutrophils, which are infection-fighting white blood cells. Colposcopy attendance
in women with High Grade Lesion of Cervix and histologi. These cookies will be stored in your
browser only with your consent.