TABLET

Defination :-
 Compressed solid unit dosage form
 Mixure of API & Excipient
 Available in different size & shape

Advantages :-
 Bitter taste can masked
 Simplest dosage form
 Easy to take
 Easy to transport
 More stable
 Low cost

Disadvantages :-
 Not suitable for older & infant
 Can’t apply in emergency
 Can’t apply in unconsciousness
 Prodocoution cost is high
 Difficult to compress crystalline drugs

Ideal Properties :-
 Good appearance
 Proper Shape & size
 Sufficient strength
 Stable
 Ecipents should stable
 Exciepents are compatible with API
 Free from microbe
 Free from contamination
 Free from sideeffects
 Free from Discolouration
 Free from cracks & chips

Types :-
1. Orally ingested
 2. Used in oral cavity
3. Used by other route
4. Used by prepare solution

Orally Ingested :-
 Compressed
 Multi compressed
 Sustained
 Enteric coate3d
 Sugar coated
 Film coated
 Chewable

Used in oral cavity :-

 Buckal
 Sublingual
 Troches
 Dental core

Other route :-
 Implantation
 Vaginal

Used by prepare solution :-

 Effervasent
 Dispensing
 Hydrophobic

Exciepents :-
Innert substances having no therapeutic effect

Used to increase stability & Aperance

Ideal Properties :-
I. Should be innert
II. Should be stable
III. Should be Acceptable
IV. Should be nontoxic
V. Should be free from microbes
VI. Should be compatible with API
VII. Colour compatible
VIII. Low cost
IX. Shouldn’t affect the Bioavailibilty of drug
Types :-
 Diluent ( provies bulk amount)
 Granulating agent ( Provies light moisture)
 Binder ( Binds API & Exciepent)
 Disintegrating agent ( helps in disintegration of tablet after administration to GIT )
 Lubricant & glaidant ( Reduces friction & increase flow property )
 Colouring agent, sweetening agent, flavouring agent ( Help to provide good appearance, Helps in
bitter taste masking )

Formulation of Tablet :-
Three formulation methods are present

1. Wet Granulation
2. Dry Granulation
3. Direct Compresssion

1. Wet Granulation :-
Process :-
 Mixing ( mix API & Excepents and ½ disintegrating agent in blender )
 Damp mass formation ( Apply Binder solution )
 Wet screening ( Pass through sieve )
 Drying ( At 60 ° Celcious )
 Dry screening ( Pass through specific sieve to get uniform sized Granules )
 Lubrication ( Apply Lubricant, Glaidant, ½ Disintegrating Agents )
 Compression ( Compress by Punching Machine )

Advantages :-
 Cohesieve & compressible properties bare good
 Good flow property
 Good Uniformicity & distribution

Disadvantages :-
 Costly ( Labour Cost )
 Timetaking

2. Dry Granulation :-
Process :-
 Mixing ( mix API & Excepents and ½ disintegrating agent in blender )
 Slug Formation ( Compress the mixure into flat tablets )
 Crushing ( Crush the slug by mill to get small particles )
 Screening ( Pass through the sieve )
 Lubrication ( Apply Lubricant, Glaidant, ½ Disintegrating Agents )
 Compression ( Compress by Punching Machine )

Advantages :-
 Suitable for heat & Moisture sensitive drugs
 Less equipment & space require
 Better Disintegration

Disadvantages :-
 Create More dust
 Not uniform colur distribution

3. Direct Compression Method ( It can apply only for those drugs who have good flow
property )

Process :-
 Mixing
 Lubrication
 Compression

Advantages :-
 Simlest method
 Less time and equipment require
 Low production cost
 Faster disintegration
 Faster dissolution