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Reference No. : 201276144 Age/Sex : 40 Years FEMALE Reg. Date : 01/12/2020 12:36
COMMENTS ON PERIPHERAL SMEAR : The red blood cells are normocytic and normochromic. The white
(Microscopy, Leishman stain) cells are normal. The platelets are adequate.
*Test performed by SYSMEX XN-550.
Absolute Neutrophil Count (ANC) <1000 - Markedly increased susceptibility of infectious diseases.
- Absolute Neutrophil Count (ANC) <500 control of endogenous microbial flora impaired.
- Absolute Neutrophil Count (ANC) <200 absent inflammatory processes.
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Reference No. : 201276144 Age/Sex : 40 Years FEMALE Reg. Date : 01/12/2020 12:36
INTERPRETATION
During coagulation sequence of reactions occur in the body in response to variety of external and or internal stimuli. The
enzymatic cascade reaction terminates in the conversion of FIBRINOGEN to fibrin, by the enzyme THROMBIN. The fibrin gel is
then converted to a stable fibrin clet by thrombin activated Factor XIII.
Finally, the fibrin network is dissolved by the enzyme PLASMIN to generate cross-linked fibrin degradation products (XL FDP).
D-Dimer comprising of two D fragments cross linked together, is the smallest plasmin
resistant molecular unit present within XL FDP.
Detection of D-Dimer is invaluable as a diagnostic marker for thrombotic conditions such as DIC, DVT and PE. D-Dimer levels
can also be used to monitor thrombolytic therapy with tPA and with streptokinase, thrombotic complications in pregnancy,
acute myocardial infarction, sickle cell crisis, severe septic infections liver disease,
DIC accompanying snake bite and prognosis and response to therapy in cancer.
REMARKS
1. D-Dimer half-life is approximately 6 hours in circulation of individuals with normal renal function. Patients with stabilized
clots and not undergoing active fibrin deposition and plasmin activation may not give detectable D-Dimer elevations
2. In PE, the larger the clot size, higher the expected level of circulating D-Dimer. Conversely, the amount of D-Dimer released
from very small clots may be diluted by the circulation and may notgive a detectable increase .
3. Fibrinolysis is a highly regulated process and in delicate dynamic balance. In case of hereditary, acquired deficiency and
dysfunction of Fibrinogen, the rate of fibrinolysis will be altered there by not giving a detectable D-Dimer level.
4. As with any laboratory test, detection of elevated levels of XL FDP in a specimen should be correlated with clinical findings.
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Reference No. : 201276144 Age/Sex : 40 Years FEMALE Reg. Date : 01/12/2020 12:36
INTERPRETATION :-
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Reference No. : 201276144 Age/Sex : 40 Years FEMALE Reg. Date : 01/12/2020 12:36
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Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokin. It is secreted by T
cells and macrophages to stimulate immunresponse to trauma, especially burns or other tissue damage leading to
inflammation. Elevated levels are observed in a variety of inflammatory processes, including infections and collagen vascular
diseases.
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