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69:655-662, 2011
Purpose: To test the hypothesis that facial symmetry affects both 2-dimensional (2D) and 3-dimesional
(3D) cephalometric measurements.
Methods: A baseline model of a preferred symmetrical face was first constructed. It consisted of a set
of commonly used cephalometric landmarks. Seven cephalometric measurements were selected for
testing. Each of them represented a different set of geometrical conditions related to the geometric
parameters being measured, the elements involved, and the type of measurements. They served as a
control group. The baseline model was then modified to simulate 10 different asymmetric models, 6
with maxillary asymmetries and 4 with mandibular asymmetries. The same 7 cephalometric analysis were
utilized again on each of the 10 asymmetric models. They served as an experimental group.
Results: The resulted measurements were tabulated and compared. For the measurements of shape, the 2D
cephalometric measurement was distorted by roll and yaw asymmetries, while the same measurement in 3D
was not. For the measurements of size, the 2D measurement was also distorted by yaw, but not by roll, while
again this measurement in 3D was not distorted. For measurements of position, the results were reversed. The
2D cephalometric measurements of position were not distorted, while all measurements in 3D were distorted.
Of note, the magnitude of the distortion was much larger for the linear measurement than angular measure-
ment. Finally, measurements of orientation, both 2D and 3D measurements were distorted by asymmetry,
although the magnitude of the distortion was larger for the 3D measurements.
Conclusion: This study confirmed the hypothesis that facial asymmetry affects both 2D and 3D cephalo-
metric measurements. It also demonstrated that the effects of asymmetry on cephalometric measurements
depend on the geometric parameter being measured (ie, shape, size, position, or orientation).
© 2011 American Association of Oral and Maxillofacial Surgeons
J Oral Maxillofac Surg 69:655-662, 2011
Two-dimensional (2D) lateral cephalometric analyses termining position, the information is limited to the
are used to measure the shape, size, position, and anteroposterior and vertical dimensions. In determining
orientation of different facial units. These analyses are orientation, the data are limited to pitch. In determining
done on lateral cephalometric radiographs. In these size, the parameters are limited to length and height. In
radiographs, all facial structures are projected onto a determining shape, the analysis is restricted to projec-
single sagittal plane. However, the information that tions in the sagittal plane. Despite these limitations,
can be gathered from these images is limited. In de- clinicians have found lateral cephalometric analyses use-
*Chairman, Department of Oral and Maxillofacial Surgery, Meth- Houston, Houston, TX.
odist Hospital, Houston, TX; Professor of Clinical Surgery (Oral and ‡Professor and Chief, Division of Pediatric Plastic Surgery, De-
Maxillofacial Surgery), Weill Medical College, Cornell University, partment of Pediatric Surgery, The University of Texas Health
New York, NY; and Associate Professor, Department of Pediatric Science Center at Houston, Houston, TX.
Surgery, The University of Texas Health Science Center at Houston, Address correspondence and reprint requests to Dr Xia: Depart-
Houston, TX. ment of Oral and Maxillofacial Surgery, The Methodist Hospital,
†Director, Surgical Planning Laboratory, Department of Oral and Research Institute, 6560 Fannin St, Suite 1228, Houston, TX 77030;
Maxillofacial Surgery, Methodist Hospital Research Institute, Hous- e-mail: JXia@tmhs.org
ton, TX; Associate Professor of Surgery (Oral and Maxillofacial © 2011 American Association of Oral and Maxillofacial Surgeons
Surgery), Weill Medicine College, Cornell University, New York,
0278-2391/11/6903-0009$36.00/0
NY; and Associate Professor, Departments of Pediatric Surgery and
doi:10.1016/j.joms.2010.10.046
Orthodontics, The University of Texas Health Science Center at
655
656 FACIAL ASYMMETRY AND CEPHALOMETRY
Lines
Sella-nasion S-N
ful and have used them to study facial growth, to ap- Nasion-point A N-A
praise facial deformities, to plan treatment, and to eval- Facial line N-Pg
uate outcomes. The usefulness of these analyses arises Upper incisor Average (U1-R, U1-L),
from the fact that most individuals have facial symmetry. average (U1A-R, U1A-L)
In this group of patients, most clinically relevant mea- Lower incisor Average (L1-R, L1-L),
average (L1A-R, L1A-R)
surements can be determined from a lateral analysis. Co-Go Average (Co-R, Co-L),
Nevertheless, as many as one third of patients with average (Go-R, Go-L)
dentofacial deformities have facial asymmetries.1 There- Go-Me Average (Go-R, Go-L), Me
fore, the effects of these types of deformities on 2D Planes
lateral cephalometric measurements needs to be estab- Frankfort horizontal Po-R, Po-L, average (Or-R,
Or-L)
lished. Preliminary observations completed in our labo- Maxillary occlusal plane U6-R, U6-L, average (U1-
ratory suggest that facial asymmetry can distort 2D ceph- R, U1-L)
alometric measurements and that these distortions Mandibular occlusal plane L6-R, L6-L, average (L1-R,
cannot be prevented by the standard practice of averag- L1-L)
ing bilateral landmarks. Mandibular plane Go-R, Go-L, Me
We are experiencing a paradigm shift in computer- Abbreviations: For abbreviations, see Table 1.
aided surgical simulation for craniomaxillofacial surgery Gateno, Xia, and Teichgraeber. Facial Asymmetry and Cepha-
as we transit to 3-dimensional (3D) cephalometry.2 This lometry. J Oral Maxillofac Surg 2011.
GATENO, XIA, AND TEICHGRAEBER 657
iterative fashion until the common cephalometric mea- cephalometric measurements. Seven different cepha-
surements inscribed by them were averaged. The pitch lometric measurements were selected for testing
of the entire computer model was then adjusted so that (Table 3). These measurements were selected be-
none of the cephalometric planes (eg, Frankfort hori- cause each represented a different set of geometric
zontal [FH]) was parallel to the horizontal plane of the conditions related to the geometric parameters be-
coordinate system. This was done to prevent lack of ing measured (shape, size, position, and orienta-
effect during testing, which occurs when the axis of tion), the elements involved (ie, points, lines, and
rotation of an object is perpendicular to a reference planes), and the type of measurements (distances
plane. Perfect mirror symmetry was created between and angles; Table 3).
the right and left points, and the origin of the coordinate The experiment was made up of 2 parts. In the first
system was set to coincide with the nasion. part, we examined the effect of asymmetry on 2D
In the second step of the study we modified the cephalometric measurements and in the second part
baseline model to create 10 different asymmetric its effect of 3D measurements. Each part required a
models, 6 with maxillary asymmetries and 4 with separate experimental group. However, both shared
mandibular asymmetries. In the 6 maxillary models, 2 the same control group. The control group was com-
had roll deformities of different severities (5° and posed of the collection of cephalometric measure-
10°), 2 had yaw deformities of 5° and 10°, and the 2 ments made on the symmetric baseline model. In this
had transverse-translational deformities of 5 and 10 group, all measurements were done in 3 dimensions
mm. In the 4 mandibular models, 2 had roll deformi- with the exception of the gonial angle, which was
ties of 5° and 10°, and 2 had yaw deformities of the calculated after the involved landmarks (condylion-
same magnitudes (Fig 1). The roll and yaw deformities gonion-menton) had been projected on the midsagit-
were created by rotating the maxillary or mandibular tal plane of this model. In the experimental groups,
landmarks around nasion. After extensive testings, we
selected the center of rotation around the nasion over
other different possible centers because it produced Table 3. SEVEN SELECTED DIFFERENT
asymmetries that were similar to those commonly CEPHALOMETRIC MEASUREMENTS FOR TESTING
seen in clinical practice. In addition, this center was
Geometric Cephalometric Type of
selected because this location prevented the lack of Parameter Measurement Measurement
effect during testing that is often seen when a sym-
metrical object is rotated around its axis of symmetry. Shape Gonial angle (Co-Go-Me) Line-line angle
Roll deformities were simulated by rotating the max- Size ANS-PNS Linear distance
Position SNA Line-line angle
illary or mandibular points around the anteroposterior Ricketts convexity Linear distance
(y) axis of nasion, and yaw deformities were simu- Orientation Interincisal angle (U1-L1) Line-line angle
lated by rotating the same landmarks around its ver- U1-FH Line-plane angle
tical axis (z). The maxillary transverse-translation OP-FH Plane-plane angle
models were created by moving the maxillary points Abbreviations: FH, Frankfort horizontal; OP, occlusal plane.
sideways (x axis). For other abbreviations, see Table 1.
These computer models were used to test the hy- Gateno, Xia, and Teichgraeber. Facial Asymmetry and Cepha-
potheses that facial asymmetry affects 2D and 3D lometry. J Oral Maxillofac Surg 2011.
658 FACIAL ASYMMETRY AND CEPHALOMETRY
Transverse
¢ ¡ Translation
Control Roll 10° Roll 5° Yaw 5° Yaw 10° 5 mm 10 mm
Shape
Gonial angle 124° 2D ⫺0.50 ⫺0.47 ⫺0.46 ⫺0.44
3D 0 0 0 0
Size
ANS-PNS 50 mm 2D 0 0 ⫺0.18 ⫺0.74
3D 0 0 0 0
Position
SNA 82° 2D 0 0
3D 0.03 0.13
Ricketts convexity 2 mm 2D 0 0
3D 3.39 8.20
Orientation
U1-L1 130° 2D ⫺0.28 ⫺0.07 0.07 0.29
3D ⫺0.89 ⫺0.27 0.04 0.17
U1-FH 114° 2D 0.23 0.06 ⫺0.06 ⫺0.23
3D 1.96 0.50 ⫺0.05 ⫺0.08
OP-FH 7° 2D ⫺0.26 ⫺0.07 0.22 0.50
3D 5.02 1.57 0.24 0.34
Abbreviations: 2D, 2 dimensions; 3D, 3 dimensions. For other abbreviations, see Tables 1 and 3.
Gateno, Xia, and Teichgraeber. Facial Asymmetry and Cephalometry. J Oral Maxillofac Surg 2011.
Three-dimensional orientations (U1-lower incisor [L1], PNS) was also distorted by yaw, but not by roll,
U1-FH, and OP-FH) were calculated using the following whereas this measurement in 3 dimensions was not
equations. Line-line angles (U1-L1) were calculated us- distorted. For measurements of position (SNA and
ing the equation Ricketts convexity of point A), the results were
reversed. The 2D cephalometric measurements of
⫽ acos([a ⫻ b] ⁄ |aⱍ ⫻ |b|). position were not distorted, whereas all 3D mea-
Line-plane angles (U1-FH) were determined by first cal- surements were distorted. Of note, the magnitude
culating the plane’s normal vector and then using the of the distortion was much larger for the linear
formula for 2 lines to calculate the angle between the measurement (Ricketts convexity) than for the an-
normal vector and the line. A normal vector is a vector gular measurement (SNA). The 2D and 3D measure-
that is perpendicular to the plane. It can be calculated ments of orientation were distorted by asymmetry,
by the cross product (a ⫻ b) of 2 vectors lying on the although the magnitude of the distortion was larger
plane given 2 coplanar vectors a and b: for the 3D measurements.
SHAPE MEASUREMENT
Results
In the presence of facial symmetry, the measure-
The results of the study are presented in Table 4. ment of shape (gonial angle) was distorted when it
The 2D cephalometric measurement of shape (go- was measured using conventional 2D cephalome-
nial angle) was distorted by roll and yaw asymme- try. However, this distortion was not seen in the 3D
tries, whereas the same measurement in 3 dimen- measurements. Asymmetry distorted 2D cephalo-
sions was not. The 2D measurement of size (ANS- metric measurements of shape because in 2D
660 FACIAL ASYMMETRY AND CEPHALOMETRY
FIGURE 3. In this example, the gonial angle (shape) of a mandible with intrinsic symmetry is measured. The local coordinate system of the
mandible is shown as a surrounding box. The local midsagittal plane is in the middle of the surrounding box. Although the mandible should
be projected to local and world midsagittal planes, for this demonstration, the 2-dimensional projection on the local midsagittal plane is
moved to the right side of the surrounding box, whereas the 2-dimensional projection on the world midsagittal plane is moved to the
left side of the world coordinate system. A, When the yaw and roll of the mandible are 0°, the local coordinate system of the mandible
is completely parallel to the world coordinate system. Therefore, the 2-dimensional projection of the mandible on the local midsagittal
plane (red) is the same as the projection on the world midsagittal plane (blue). Both projected gonial angles are measured at 127°.
B, When the mandible is rotated to produce 20° of yaw and the roll remains at 0°, the local coordinate system is no longer parallel
to the world coordinate system. The gonial angle projected on the local midsagittal plane remains the same at 127° (red) because its
local coordinate system is rotated together with the mandible. However, the gonial angle projected on the world midsagittal plane is
distorted and increased to 130° (blue).
Gateno, Xia, and Teichgraeber. Facial Asymmetry and Cephalometry. J Oral Maxillofac Surg 2011.
cephalometrics this parameter was measured on a metries, the projected image was no longer a facsimile
projected 2D image. When an object was oriented of the object. Figure 3 illustrates this phenomenon.
orthogonal to the film, the projected image corre- Conversely, in 3 dimensions, the measurement of shape
sponded to the object. However, when an object was not distorted because the method used to measure
was obliquely oriented to the film, as in most asym- this parameter in 3 dimensions was unaffected by the
GATENO, XIA, AND TEICHGRAEBER 661
SIZE MEASUREMENT
In the presence of facial asymmetry, the measure-
ment of size (ANS-PNS) was distorted when measured
on the 2D films. However, this did not occur with the
direct 3D measurements. The reason for the distor-
tion in 2D cephalometry was the same as for the
measurement of shape. The projected 2D image did
not correspond to the object because the object was
not orthogonal to the film. Another finding of the 2D
arm of the study was that the 2D measurement of size
(ANS-PNS) was distorted only in the yaw asymmetry FIGURE 4. This model is oriented in the cardinal direction of the
face (anterior, posterior, head, foot, right, and left).
models. Roll asymmetries did not distort the measure-
ment. This occurred because ANS-PNS was a measure- Gateno, Xia, and Teichgraeber. Facial Asymmetry and Cepha-
lometry. J Oral Maxillofac Surg 2011.
ment of length (anteroposterior dimension) and the
simulated roll asymmetries did not change the antero-
posterior position of the 2 points that bound this line which the measurement is taken becomes oblique to
segment. If we had selected a measurement of height the sagittal plane. In this scenario, the direction of the
(vertical dimension) instead of a length measurement measurement is no longer truly anteroposterior because
for testing, we would have seen the opposite effect. an irrelevant “third” dimension, an x coordinate (in
Because the 3D measurements are never distorted, it transverse dimension), is also taken into the computa-
can be concluded that, for size measurement, direct tion. Therefore, with regard to position measurements,
3D measurements are superior. it can be concluded that measurements of projected 2D
points on the sagittal plane are superior to direct 3D
POSITION MEASUREMENT measurements.
In the presence of facial asymmetry, the results for
the position measurements were opposite to those ORIENTATION MEASUREMENT
seen for shape and size. Although the measurements In the presence of facial asymmetry, the results of
were not distorted in 2 dimensions, they were dis- the orientation measurements demonstrated that 2D
torted in 3 dimensions. This phenomenon can be and 3D measurements were distorted. The 2D mea-
better explained by the basic principles of 3D geom- surements of orientation were distorted because in 2
etry. To determine the position of any point requires dimensions the orientation of an object has a marked
a frame of reference. The frame of reference of the effect on the landmark positions.3,4 Figure 5 illustrates
face consists of 3 perpendicular planes (axial, coro- this phenomenon. When the object is orthogonal to
nal, and sagittal) oriented to 6 cardinal directions the film, the projected landmarks reflect the object.
(anterior, posterior, cranial, caudal, right, and left; However, when the object is tilted (roll or yaw), the
Fig 4). In this system, any measurement of anteroposte- position of the projected landmarks changes, thus
rior position (eg, SNA, Ricketts convexity) must be done distorting the value of the measured angle.
on a sagittal plane. In traditional 2D cephalometrics, all The 3D measurements of orientation were also dis-
points are projected on a film that is parallel to the torted in the models with roll or yaw asymmetries.
sagittal plane and only (y, z) coordinates are calculated This phenomenon can also be explained by the basic
(Fig 4). Therefore, the direction of the measurements in principles of 3D geometry. The orientation of an ob-
the anteroposterior position is always correct, even in ject is a description of how it is aligned to the space
the presence of facial asymmetry. However, the same is that it inhabits. Orientation is given relative to a frame
not true in 3D measurements, in which all (x, y, z) of reference usually specified by a Cartesian coordi-
coordinates are calculated (Fig 4). In subjects with facial nate system. The orientation of an object is estab-
asymmetry, when 1 of the cephalometric points is dis- lished by describing the rotation that would move the
placed away from the midsagittal plane, the plane on object from its base or starting orientation to its cur-
662 FACIAL ASYMMETRY AND CEPHALOMETRY
FIGURE 5. The presence of facial asymmetry can affect 2- and 3-dimensional measurements. In this example, when the upper and lower
incisors were orthogonal to the film, the projected landmarks reflected the objects. The interincisal angle was measured at 137°. However,
when both incisors were tilted 20° in roll without changing their relative position and orientation, the position of the projected landmarks still
changed. The interincisor angle was measured at 133°.
Gateno, Xia, and Teichgraeber. Facial Asymmetry and Cephalometry. J Oral Maxillofac Surg 2011.
rent orientation. It can be described using 3 angles were designed to measure the pitch of specific facial
(pitch, roll, and yaw). Pitch refers to the rotation of elements on 2D cephalograms. Although not origi-
the object around transverse axis (x); roll refers to the nally intended for this purpose, these measurements
rotation of the object around the anteroposterior axis can also be used to measure the pitch of the different
(y); and yaw refers to the rotation of the object facial elements in 3D space, if the measured elements
around the vertical (z) axis. To measure these angles, have 0 roll or yaw. However, as demonstrated in this
it is necessary to have 2 separate coordinate systems, study, roll and yaw rotations may change the value of
1 for the object (local coordinate system) and 1 for the 3D cephalometric angles even if the pitch of the
the space surrounding it (world coordinate system). object remains constant. In this scenario, the mea-
The pitch, roll, and yaw are the angles between the sured 3D angle is a composite of pitch, roll, and yaw
corresponding axes of the world and local coordinate and no longer represents only pitch as originally in-
systems (Fig 6). tended. Regarding the measurements of orientation, it
The cephalometric measurements of orientation can be concluded that in the presence of facial asym-
evaluated in this study (U1-L1, U1-FH, and OP-FH) metry (abnormal roll or yaw), 2D and direct 3D mea-
surements are distorted. Although 2D measurements
in the presence of asymmetry will always be dis-
torted, it is possible to correctly measure orientation
in 3 dimensions if pitch, roll, and yaw are measured
separately. This can be accomplished by calculating
the angles between the local and the world coordi-
nates of each element (Fig 6). The technique is pre-
sented in detail in the accompanying article of 3D
cephalometry by the same investigators.2
References
1. Severt TR, Proffit WR: The prevalence of facial asymmetry in the
dentofacial deformities population at the University of North
Carolina. Int J Adult Orthodon Orthognath Surg 12:171, 1997
2. Gateno J, Xia JJ, Teichgraeber JF: A new three-dimensional
cephalometric analysis for orthognathic surgery. J Oral Maxillo-
fac Surg 68:606, 2011
3. Webster M, Sheets HD: A practical introduction to landmark-
based geometric morphometrics, in Alroy J, Hunt G (eds): Quan-
titative Methods in Paleobiology, Paleontological Society Short
FIGURE 6. The pitch, roll, and yaw are the angles between
Course, Vol 16. Paleontological Society Papers, Akron, OH,
corresponding axes of the world and local coordinate systems.
2010, p 1
Gateno, Xia, and Teichgraeber. Facial Asymmetry and Cepha- 4. Zelditch ML, Swiderski DL, Sheets DH, et al: Geometric Morpho-
lometry. J Oral Maxillofac Surg 2011. metrics for Biologists: A Primer. San Diego, Elsevier, 2004