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Title: Mastering the Literature Review on Vitamin D in Health and Disease

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To correct these misconceptions, members of the HOPES team will be going through various
depictions of HD in the media to determine what aspects of HD are presented properly and what
aspects are misrepresented. We found vitamin D to be efficacious in conditions like cardiovascular
diseases, diabetes mellitus, osteoporosis; but its role in treatment of certain conditions like multiple
sclerosis, cognition needs to be assessed further studies. Only 2% of patients on calcifediol needed
transfer to the ICU and none of them died, compared with two deaths (8%) and 50% of patients
needing ICU treatment in the control group. 202 This raises the question, whether the use of an
activated form of vitamin D may provide more benefit in acutely and severely ill patients in whom
activation of vitamin D 3 may be impaired or take too long. Vitamin D deficiency is found in 83% of
299 patients with low-back pain. These statements have not been evaluated by the Food and Drug
Administration. It is being prescribed very frequently in clinical practice. Epidemiological and animal
research suggests that vitamin D plays an important role in SLE, 81,82 and the use of vitamin D for
the treatment of lupus was first reported in the 1940s. 83. The data suggested that each 200 IU per
day increase in total vitamin D intake was associated with a 10% decrease in the risk of colorectal
adenoma (a pre-cancerous condition) and a 5% decrease in the risk of CRC. Vitamin D deficiency
causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures
in adults. Active vitamin D increases the absorption of both calcium and phosphorus in the intestine,
as well as working with PTH to reduce calcium loss in the urine and stimulate release of calcium and
phosphorus from the bone. Symptoms are portrayed as much worse than they are in reality, incorrect
diagnoses are provided, and false information is presented to audiences around the world. A wide
range of dosages appeared to be beneficial, except large bolus doses. Food sources include fatty fish,
animal liver, egg yolk and dairy products, though these are poor sources. Vitamin D has direct
effects on both adaptive and innate immune systems. In. Some people advocate a European origin
for the mutation, suggesting that migration and inter-racial mixture of genes led to a lower
prevalence in non-European countries. Mechanisms by which vitamin D may modify cancer risk are
not fully. RESULTS: The odds ratio for comorbid PreDM and PreHTN in Caucasian men. Likewise,
it is gaining importance over its classical action in health in recent era as it has some non-classical
actions such as immunomodulation, anti-inflammatory, insulin secretion enhancement etc. In the past
decade, intensive research efforts have given scientists a much better understanding of how HD
damages the brain. The first hydroxylation occurs in the liver, creating calcidiol. RESULTS: The
prevalence of vitamin D deficiency was high (85.9%). Those. As immune cells in infected patients
are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing
vitamin D-deficient individuals with an infectious disease may extend beyond the impact on bone
and calcium homeostasis. Maternal Vitamin D Supplementation to Improve the Vitamin D Status of.
In recent years, the publication of research articles investigating associations between vitamin D
status and health has reached an all-time high, and an increase in supplementation studies has
followed. Similarly, a meta-analysis just focussing on vitamin D intervention trials found that vitamin
D significantly improved progression-free survival and reduced adverse CRC outcomes by 30%, 105
with the best results seen in a study using 4000 IU per day for 23 months. 106 In the same
publication, a reduction in CRC incidence failed to reach statistical significance. Recent evidence
supports an association between vitamin D deficiency and. Exposure to UV light is greatest at the
equator and declines as you move further north or south. This section of the website gives an
introduction to the brain, focusing on the changes caused by HD. They set the daily recommended
intake of vitamin D at 600-800 IU. Patients with fibromyalgia syndrome (FMS) have impaired
mobility and.
Epidemiological studies looking at vitamin D levels and the risk of getting COVID-19 have mostly
shown that VDD is associated with a higher risk of getting COVID-19, with an up to 80% increased
risk reported, 195,196,197,198 although Pereira et al. Most foods contain very little vitamin D
naturally, though some are fortified with added vitamin D. Vitamin D2 may be equally effective for
maintaining circulatin. In today’s world ultraviolet light from the sun may be blocked by air.
International Journal of Human Nutrition and Functional Medicine 2014 Oct 3. Vasquez A.
Translating Microbiome (Microbiota) and Dysbiosis Research into Clinical Practice: The 20-Year
Development of a Structured Approach that Gives Actionable Form to Intellectual Concepts. Over
the past decades, however, it has become clear that VDRs are expressed in almost all cells, 2 and that
vitamin D has many important physiological roles, in particular in terms of modulating the immune
system. 5. Digestants and Carminatives.pdf Digestants and Carminatives.pdf Appeptite stimulants
and suppresents.pdf Appeptite stimulants and suppresents.pdf Bursitis is inflammation or irritation
of a bursa sac. Deficiency of Vitamin D leads to Hypocalcemia, which leads to a cascade of. The
supporting tissue of the nervous system; made up of neuroglial cells. In temperate climates, the
plasma concentration of vitamin D is highest at the end of summer and lowest at the end of winter.(
Download Free PDF View PDF Vitamin D and health status in elderly Laura Pini Recently, vitamin
D has aroused considerable interest for several reasons. The objectives of this study are to assess: (a)
the prevalence of vitamin D. Most populations fail to meet these recommended dietary vitamin D
requirements. Information about dietary intakes is obtained from the participants through.
OBJECTIVE: To determine whether a single monthly supplement is as. Seminario Biomol- Gwyneth
Lorena Serna Salazar Seminario Biomol- Gwyneth Lorena Serna Salazar Cell cytoskeleton and
molecular motors.pdf Cell cytoskeleton and molecular motors.pdf Seminario biologia molecular-
Universidad Pontificia Bolivariana. Such inconsistencies may be explained by a number of
limitations with regards to study designs. Some evidences showed that vitamin D deficiency might
influenced in pathogenesis of Type 2 Diabetes Mellitus that caused by insulin resistence and
dysfunction of pancreatic beta cell. Nutrition Examination Survey with mortality data obtained
through 2006. In addition, VDRs are widely present throughout the brain, implicating vitamin D3 as
a contributor to a variety of neural processes. Download Free PDF View PDF See Full PDF
Download PDF Loading Preview Sorry, preview is currently unavailable. Whilst obesity is a well
recognized risk factor, other environmental factors associated with Type 2 diabetes have been. World
Health Organization (WHO) and International Diabetes Federation (IDF) predict an increase in the
number of diabetics which become one of the global threats. An enzyme A protein that speeds up a
chemical reaction. TPRV6, both of which are involved in the absorption of calcium by intestinal.
Dosing regimens that have shown benefits varied from 1000 IU per day to 100 000 IU weekly for 8
weeks, and a single bolus dose of 300 000 IU with 12-week follow-up. Check out the HOPES Brain
Tutorial for an illustrated tour of the brain; look at our “Neurobiology” section for an in-depth look at
the cells that make up the brain; go to the “Other Neurodegenerative Conditions” section to learn
about diseases that share some similarities to HD. Healthy adults with higher serum 25(OH)D levels
had significantly lower. D-bound VDR binds to the retinoid-X receptor (RXR), and the resulting.
It’s wise to protect your skin from UV radiation by applying sunscreen, covering up with clothing
and a hat, finding shade, and avoiding sun exposure in the middle of the day. Once active, vitamin D
works in several ways to ensure blood calcium homeostasis and enhance the availability of calcium
for bone mineralization.
In the American Cancer Society's Cancer Prevention Study (CPS) II Nutrition. RESEARCH
DESIGN AND METHODS: We examined the 12,719 participants. Any links on this web site to
web sites operated by third parties are provided for your convenience only. During menopause, the
decline of estrogens results in increased bone turnover, a decrease in bone mineral density and
elevated fracture risk. Most studies have used oral vitamin D 3, but some have used vitamin D 2,
active metabolites or analogues, either orally or in injectable forms. Unless discussed specifically
under the respective condition, there was no clear trend as to whether certain dosing regimens were
superior to others. Unfavorable metabolic profiles and oxidative stress in pregnancy are. Digestants
and Carminatives.pdf Digestants and Carminatives.pdf Appeptite stimulants and suppresents.pdf
Appeptite stimulants and suppresents.pdf Bursitis is inflammation or irritation of a bursa sac.
RESEARCH DESIGN AND METHODS: We investigated the association among. When serum
calcium levels fall, vitamin D triggers the expression of genes that increase absorption of calcium in
the intestine and reabsorption through the kidneys as well as releasing calcium from the bones when
dietary intake is low. 12 In a similar way, vitamin D and PTH are also involved in phosphorous
metabolism. 13 As such, vitamin D plays an important role in bone mineralisation and with that in
bone health. Vitamin D levels and other baseline characteristics. METHODS AND RESULTS: We
measured 25-hydroxy-vitamin D (25(OH)D). Hypercalcemia can cause kidney damage and calcium
deposits to develop in soft tissues such as the kidneys, blood vessels, or other parts of the
cardiovascular system. Vitamin D supplementation has been shown to improve blood sugar and lipid
metabolism, 173,174,175 androgen levels, 172,174 inflammatory and oxidative stress markers, 176
and follicular development and menstrual cycle regulation. 177. Easy Health Options does not sell or
recommend any particular nutritional supplement, product or treatment option for any condition.
Osteoarthritis; Multiple Sclerosis; Type 1 Diabetes. Evidence of a possible cancer-protective role for
vitamin D has also. Patients with fibromyalgia syndrome (FMS) have impaired mobility and.
Hypovitaminosis D is associated with cardiovascular disease, the metabolic syndrome, type 2
diabetes mellitus, cancer as well as with increased mortality. UV light reacts with an enzyme A
protein that speeds up a chemical reaction. PCOS has been associated with low vitamin D levels.
172. Minimum thirty minutes of UV B ray exposure causes the production of 600-1000IU of vitamin
D in our body. Whilst benefits of vitamin D have been observed in healthy adults, 148 no benefits
have been seen in athletes 147,149 or postmenopausal women. 150,151 Findings in elderly people are
mixed, with some studies showing small improvements in some strength tests, 152 whilst others
show no additional benefit of vitamin D in addition to that of exercise. 153. Deficiency of Vitamin D
leads to Hypocalcemia, which leads to a cascade of. Download Free PDF View PDF See Full PDF
Download PDF Loading Preview Sorry, preview is currently unavailable. Vitamin D can be obtained
from two different sources: nutrition and cutaneous synthesis. Vitamin D levels should be monitored
to ensure supplements sufficiently raise vitamin D levels. The information we present is intended for
educational purposes only and should not be construed as offering diagnoses or recommendations.
Jacobs reported two cases showing a reduction in frequency, duration. There is high prevalence of
vitamin D deficiency in children with limb.
Likewise, in the summer months, the sun is directly overhead for a greater part of the day, so you
have more opportunities to synthesize vitamin D. Medical Research (G.B.), Special Report Series
SRS-61:1-78 (1921).; Hess, A. Influence of light on the prevention of rickets. We hope this medium
allows information to be more accessible and educational for audiences, and creates a space to
discuss topics important to the HD community. Vitamin D deficiency as emerging epidemic have
effect on pathophysiology of diabetes mellitus by various mechanisms, so we have taken up this
study with aim to see effect of both high prevalent diseases on each other and to observe prevalence
and pattern of vitamin D deficiency in diabetics.Methods: In this case-control study 70 type 2
diabetic patients were taken as cases and 70 healthy individuals as controls. A number of
observational studies have investigated whether people. The sample consist of 33 prediabetic
subjects, 30 controlled Type 2 DM subejcts, and 30 uncontrolled Type 2 DM. Sunlight is an essential
ingredient in this process, so vitamin D is sometimes called the “sunshine vitamin.” However, the
amount of vitamin D synthesized in the body is often not enough to meet our needs, so many people
also need to consume dietary sources. Circulatory shock Cardiogenic Shock Hypovolemic Shock
Sepsis, Septic Shock an. CAG demonstrated significant CAD in 70 patients (35%). The major cause
of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major
source of vitamin D for most humans. Your location on Earth and the time of the year affects your
exposure to UV radiation from the sun. Methods: Present study was carried out in 912 subjects (429
T2DM cases and 483 non-diabetic controls) from Western India. Vitamin D deficiency has been
associated with increased risk of common cancers, autoimmune diseases, hypertension, and
infectious diseases. A lot of research has therefore focussed on the role of vitamin D in bone health,
in particular in the prevention and treatment of osteoporosis and fractures. Weekly dosing or greater
dosing intervals also appear to be beneficial and safe. The study that used vitamin D 3 found a
significant PSA response with 10 000 IU per day for 3?8 weeks. 109 The 2019 meta-analysis also
reviewed 16 uncontrolled trials that showed a modest benefit of vitamin D on PSA response rate,
with 19% of patients having a reduction of at least 50%. 108 Most of these studies used the
activated calcitriol form of vitamin D. Vitamin D has a unique metabolism as it is mainly obtained
through synthesis in the skin under the influence of sunlight (i.e., ultraviolet-B radiation) whereas
intake by nutrition traditionally plays a relatively minor role. Louis reported that more than half of
313 patients undergoing spinal fusion. International College of Human Nutrition and Functional
Medicine, 2014 5. Vitamin D supplementation trials have confirmed benefits for some conditions,
including atopic dermatitis, chronic urticaria, colorectal cancer, depression, polycystic ovary
syndrome and type 2 diabetes mellitus, but not others, such as multiple sclerosis, prevention of
allergic sensitisation in infants and psoriasis. Whilst one review found no benefits, 118 others saw
improvements in specific subgroups: in patients with hypertension and VDD at baseline, 119,120,121
or together with calcium in younger adults. 122 Most studies showed significant heterogeneity, and
only one found dosage to be a significant factor, with dosages of 5000 IU per day or more being
more effective. Some people advocate a European origin for the mutation, suggesting that migration
and inter-racial mixture of genes led to a lower prevalence in non-European countries. In the
American Cancer Society's Cancer Prevention Study (CPS) II Nutrition. OBJECTIVE: This study
was designed to assess the effects of vitamin D. Source: Examples of good sources pictured include
salmon, milk, mushrooms, fortified soy milk, and fortified cereal. Hodgkin lymphoma. He proposes
that adequate exposure to ultraviolet. The suboptimal levels of vitamin D may contribute to many
conditions including rickets, osteomalacia, osteoporosis, falls and fractures. We are not responsible
for the content and performance of these web sites or for your transactions with them, and our
inclusion of links to such web sites does not imply endorsement. This is the circulating form of
vitamin D and the form measured in blood to assess a person’s vitamin D status. JULIANA
BENAVIDES GUERRERO Digestants and Carminatives.pdf Digestants and Carminatives.pdf
Koppala RVS Chaitanya Appeptite stimulants and suppresents.pdf Appeptite stimulants and
suppresents.pdf Koppala RVS Chaitanya Bursitis is inflammation or irritation of a bursa sac.
Application aux poissons pelagiques cotiers des zones d’upwelling Christophe Le Page Download
Free PDF View PDF Animals Peroxisome Proliferator-Activated Receptor ?, but Not. Besides this,
vitamin D is likely to be associated with prevention against different types of cancers and chronic
diseases like cardiovascular diseases, hypertension, diabetes mellitus and stroke as well as
osteoporosis. Alternative Therapies in Health and Medicine 2004 6. Hypovitaminosis D is associated
with insulin resistance and beta-cell. Whilst some find a benefit of supplementation with vitamin D
plus calcium, 90,91,92 others did not find any benefits of either vitamin D, calcium or a combination
of the two. 93,94,95. For an over-all introduction to Drugs and Supplements, click here. D
deficiency has been linked to caesarean section in a single recent study. This particular vitamin is
found in many food sources, including milk, eggs, and fish, and it can also be produced by the skin
through sunlight exposure. The major cause of vitamin D deficiency is the lack of appreciation that
sun exposure in moderation is the major source of vitamin D for most humans. You can download
the paper by clicking the button above. Whilst improvements have been seen in some markers,
including biomarkers for angiogenesis, 100 total antioxidant capacity 101 and 27-hydroxycholesterol
(27HC; which is involved in the development of oestrogen-positive breast cancer), 102 no significant
changes were seen in others, including tumour proliferation or apoptosis biomarkers 103 and
inflammatory markers. 101. You can download the paper by clicking the button above. Elgar has
received consultancy fees from Pure Encapsulations, Sudbury, MA, USA. Bursitis is inflammation or
irritation of a bursa sac. Summary of the data: Of the 1475 studies, 09 were included. Its main
function is in the regulation of calcium absorption and homeostasis; most of its actions are mediated
by way of nuclear receptors that regulate gene expression. RESEARCH DESIGN AND METHODS:
A total of 6,537 of the 11,247 adults. A recent meta-analysis reviewed studies looking at vitamin D
supplementation and adipokines, but found no effects. 165. Vitamin D has a well-known role in
calcium homeostasis and bone metabolism. In addition, avoiding a status of vitamin D deficiency to
obtain its positive effects on the immune system and its protective mechanism during infections will
be a general benefit overall. Deficiency of Vitamin D leads to Hypocalcemia, which leads to a
cascade of. Vitamin D deficiency is found in 83% of 299 patients with low-back pain. Exposure to
UV light is greatest at the equator and declines as you move further north or south. The World
Health Organization has responsibility for defining the. Hodgkin lymphoma. He proposes that
adequate exposure to ultraviolet. Alternative Therapies in Health and Medicine 2004 6. RESULTS:
Higher 25(OH)D(3) was significantly associated with a reduced. This undergoes a further reaction
over a period of hours to form cholecalciferol, which is absorbed into the bloodstream. Their report,
issued at the end of 2010, 1 found what they considered to be strong evidence for only one health
outcome: skeletal health. Vitamin D is not strictly a vitamin, since it can be synthesized in the skin,
and under most conditions that is the major source of the vitamin.
Dosing regimens that have shown benefits varied from 1000 IU per day to 100 000 IU weekly for 8
weeks, and a single bolus dose of 300 000 IU with 12-week follow-up. Ozone and air pollution can
also block UV rays and decrease vitamin D synthesis. One should consider at least 2000 IU per day
whilst monitoring vitamin D levels to ensure patients achieve adequate levels. BMJ Risk Factors
Vitamin D Deficiency See Full PDF Download PDF About Press Blog People Papers Topics Job
Board We're Hiring. Cells throughout the body have vitamin D receptors in their nuclei, and by
binding to these receptors, vitamin D is thought to regulate the expression of hundreds of genes. The
information we present is intended for educational purposes only and should not be construed as
offering diagnoses or recommendations. This article is the independent work of the author and Pure
Encapsulations was not involved in the decision to publish this research. In view of the emerging
coronavirus disease 2019 (COVID-19) pandemic, searching for potential therapeutic and protective
strategies is of urgent interest, and vitamin D is one of the promising agents in this field. Health and
Nutrition Examination Survey 2001-2006 were assessed. RAMOS, Valter Araga?o Goals: To verify
whether the use of Vitamin D as parallel therapy to hospital and drug treatment can be effective in
the process of infectious reduction in hospitalized children. The data suggested that each 200 IU per
day increase in total vitamin D intake was associated with a 10% decrease in the risk of colorectal
adenoma (a pre-cancerous condition) and a 5% decrease in the risk of CRC. Postoperatively, she had
hungry bone syndrome, which she gradually. No other funding or sponsorship has been received for
this work. So while no one can choose their own genes, people at risk for HD can choose a healthy
lifestyle. CONCLUSIONS: This study strengthens the plausibility that low serum. Download Free
PDF View PDF Journal of Shifa Tameer-e-Millat University Vitamin D deficiency: It's contributing
factors and prevention Zahid Naeem Vitamin D deficiency is prevalent across the globe. Results:
Vitamin D deficiency was seen in 91.4% and 93.0% of T2DM cases and control subjects
respectively. Beyond that, dietary sources and supplements may be needed to meet the vitamin D
requirement. 2. Vitamin D was first recognised for its importance in calcium metabolism and
therefore bone health, with the classic deficiency disease being rickets in children and osteomalacia
in adults, but is now also known for its importance in modulating immunity. In another study, the
European Prospective Investigation into Cancer and. Another phase 3 clinical trial is currently
underway to confirm these results. 107. Current best evidence demonstrates that supplemental
vitamin D can. However, rickets does still occur in breastfed infants and children raised on vegan
diets who aren’t provided with other sources of vitamin D, particularly if they have darker skin
pigmentation. 1,3. People with old age, dark skinned and obese cannot produce sufficient amount of
Vitamin D. You can download the paper by clicking the button above. International Journal of
Human Nutrition and Functional Medicine 2014 Oct 3. Vasquez A. Translating Microbiome
(Microbiota) and Dysbiosis Research into Clinical Practice: The 20-Year Development of a
Structured Approach that Gives Actionable Form to Intellectual Concepts. Lancet 2:1222 (1922).;
Steenbock, H. The induction of growth promoting and. RESULTS: The odds ratio for comorbid
PreDM and PreHTN in Caucasian men. Bursitis is inflammation or irritation of a bursa sac. It is
thought to be due to a dysfunction of both the innate and adaptive immune systems, and issues with
the barrier function of the skin. 33 Observational studies have shown that low serum levels of vitamin
D are associated with AD. 34.
Vitamin D is not strictly a vitamin, since it can be synthesized in the skin, and under most conditions
that is the major source of the vitamin. This article is the independent work of the author and Pure
Encapsulations was not involved in the decision to publish this research. Digestants and
Carminatives.pdf Digestants and Carminatives.pdf Appeptite stimulants and suppresents.pdf
Appeptite stimulants and suppresents.pdf Bursitis is inflammation or irritation of a bursa sac.
However, there was a much greater increase in vitamin D level from a lower baseline in the vitamin
D group. CONCLUSIONS: Low 25(OH)D(3) levels in Caucasian children are inversely. Vitamin D3
and the brain Vitamin D3 and neurodegenerative disorders Conclusion Works Cited. Alternative
Therapies in Health and Medicine 2004 6. Medial calcification is associated with proliferation of
vascular smooth. Epidemiologic studies of the association between vitamin D and breast. Studies
have found correlations between low circulating vitamin D levels and increased risks of chronic
diseases, including cancer, diabetes, cardiovascular disease, and multiple sclerosis. Vitamin D lowers
blood pressure by affecting the renin angiotensin. In addition, VDRs are widely present throughout
the brain, implicating vitamin D3 as a contributor to a variety of neural processes. To browse
Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade
your browser. In view of the emerging coronavirus disease 2019 (COVID-19) pandemic, searching
for potential therapeutic and protective strategies is of urgent interest, and vitamin D is one of the
promising agents in this field. Food sources include fatty fish, animal liver, egg yolk and dairy
products, though these are poor sources. Our goal is to survey the rapidly growing scientific
literature on HD and to present this information in a web source. Study who were free of clinical
cardiovascular disease at baseline. We. However, because people with obesity are at increased risk for
many conditions associated with VDD, supplementation should be considered, especially in those
with VDD. Your location on Earth and the time of the year affects your exposure to UV radiation
from the sun. It is being prescribed very frequently in clinical practice. Synthesis of vitamin D from
the sun does not cause vitamin D toxicity, because vitamin D synthesis is tightly regulated and
decreases if the body has abundant vitamin D. In addition, avoiding a status of vitamin D deficiency
to obtain its positive effects on the immune system and its protective mechanism during infections
will be a general benefit overall. A number of observational studies have investigated whether people.
This particular vitamin is found in many food sources, including milk, eggs, and fish, and it can also
be produced by the skin through sunlight exposure. It has long been known that blood pressure is
higher in the winter than. RESULTS: Thirty seven patients with vitamin D deficiency participated in
the. You can download the paper by clicking the button above. Current best evidence demonstrates
that supplemental vitamin D can. BP 80-89 mmHg. Logistic regression was used to assess the effects
of low. Latin American and Caribbean Health Sciences (Lilacs), Scopus and Web of Science.

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