Are you struggling with crafting a comprehensive literature review on Vitamin D?

Writing a
literature review can be a daunting task, requiring extensive research, critical analysis, and effective
synthesis of existing literature. It demands time, effort, and expertise to gather relevant studies,
evaluate their findings, and present a cohesive overview of the current state of knowledge on the
subject.

Navigating through the vast expanse of scholarly articles, journals, and research papers can be
overwhelming, especially for those with limited experience in academic writing or specific subject
areas. Identifying relevant sources, analyzing data, and integrating diverse perspectives into a
coherent narrative requires both skill and precision.

If you find yourself overwhelmed by the complexities of writing a literature review on Vitamin D,
fret not. Help is just a click away. At ⇒ StudyHub.vip ⇔, we specialize in providing professional
assistance with academic writing tasks, including literature reviews. Our team of experienced writers
possesses the expertise and knowledge needed to deliver high-quality literature reviews tailored to
your requirements.

By entrusting your literature review to us, you can save time, alleviate stress, and ensure the quality
of your work. Our writers conduct thorough research, critically evaluate existing literature, and
present their findings in a clear and organized manner. Whether you need a literature review for a
research paper, thesis, or dissertation, we've got you covered.

Don't let the challenges of writing a literature review hold you back. Order from ⇒ StudyHub.vip
⇔ today and take the first step towards academic success. With our professional assistance, you can
achieve your goals and excel in your academic endeavors.
Among the main environmental factors studied, those more likely associated with MS include certain
viruses, smoking, and hypovitaminosis D. The study that used vitamin D 3 found a significant PSA
response with 10 000 IU per day for 3?8 weeks. 109 The 2019 meta-analysis also reviewed 16
uncontrolled trials that showed a modest benefit of vitamin D on PSA response rate, with 19% of
patients having a reduction of at least 50%. 108 Most of these studies used the activated calcitriol
form of vitamin D. Ciebiera, Michal, Marta Wlodarczyk, Magdalena Ciebiera, Kornelia Zareba,
Krzysztof Lukaszuk, and Grzegorz Jakiel. It has long been known that blood pressure is higher in the
winter than. Two hydroxylation reactions for the Vitamin D prohormones for activation, the first
hydroxylation takes place in the liver and intermediate called 25-hydroxyvitamin D (also called
Calcidiol) are formed. In the American Cancer Society's Cancer Prevention Study (CPS) II
Nutrition. Despite the accumulating data on UFs, information about the involvement of vitamin D in
their pathophysiology is limited. If these target intakes are applied at an individual level, they are
supposed to meet the needs of the majority, especially for the high-risk groups. The World Health
Organization has responsibility for defining the. However, World Health Organization (WHO) has
recommended nutrients intakes (RNIs) for vitamin D in 2004. It is being prescribed very frequently
in clinical practice. Patients with congestive heart failure were recently found to have. Vitamin D 2,
or ergocalciferol, is of plant or fungal origin. 2 Although we can get vitamin D through our diet, it is
strictly speaking not a vitamin but a steroid hormone. 3 Vitamin D 3 is metabolised in the liver to 25-
hydroxyvitamin D 3, also called calcifediol or calcidiol, which is converted further in the kidneys to
1?,25-dihydroxyvitamin D 3, the biologically active form of vitamin D that binds to vitamin D
receptors (VDRs). 4. In 2013, Halder et al., demonstrated that vitamin D increased TIMP expression
in the uterine myometrium. DEXA scans, however, only measure BMD and do not assess the
structural micro-architecture of the bone tissue, and therefore may not accurately reflect risk of
fractures. 88 There are well over 50 RCTs looking into the role of vitamin D either alone or with
calcium in osteoporosis. Results- Among the 100 T2DMpatients, 46% had deficiency, 22% had
insufficiency and 32% had sufficiency of vitamin D3. Nutrition is the relationship of foods to the
health of the human body. Changes in VTD levels and HbA 1c levels are summarized in Table 1.
These can be very allergenic and contained high levels of unneed ed vitamin A. VDD is common in
patients with IBD, although it is unclear whether this is a cause or a consequence of the disease. 47.
No statistically significant differences in the anthropometric parameters between case and control
groups were observed. Alternative Therapies in Health and Medicine 2004 6. One of the most
recently published studies on these correlations was published in 2015. Journal of Theoretical and
Applied Electronic Commerce Research (JTAER). You can download the paper by clicking the
button above. It is unlikely to result in Vitamin D toxicity from excessive sun exposure and high
intakes of dietary Vitamin D. Deficiency of Vitamin D leads to Hypocalcemia, which leads to a
cascade of. Nutrition Examination Survey with mortality data obtained through 2006. Hodgkin
lymphoma or cancers of the endometrium, esophagus, stomach. REFERENCE: THE CLINICAL
IMPORTANCE OF VITAMIN D (CHOLECALCIFEROL): A PARADIGM SHIFT WITH
IMPLICATIONS FOR ALL HEALTHCARE PROVIDERS; Alex Vasquez, DC, ND, Gilbert
Manso, MD, John Cannell, MD.
Patient with rickets may feel difficulty in breathing due to the deformity of ribs. Vitamin D is mostly
made in the skin by exposure to sunlight. In temperate climates, the plasma concentration of vitamin
D is highest at the end of summer and lowest at the end of winter.( Download Free PDF View PDF
Vitamin D and health status in elderly Laura Pini Recently, vitamin D has aroused considerable
interest for several reasons. Further well-designed studies may find optimal dosing regimens as well
as those populations who may benefit most. Editor’s Choice articles are based on recommendations
by the scientific editors of MDPI journals from around the world. They constitute one of the most
common pathologies of the female genital tract. Results: There was no significant difference between
case and control groups in terms of age, sex, body mass index and used medications. Lower 25-
OHD and higher PTH concentrations appears to increases sudden. However, some of the bonds in
the rings of Vitamin D are broken (Figure 3). Funding This study was funded by Centre of
Postgraduate Medical Education. Vitamin D, GnRH analogs and SPRMs. According to Ali et al. In
addition, Full body exposure to sunlight is fortified with 3,000-20,000 IU (International Units) of
Vitamin D (unshineVitamin.org, n.d). However, the sun is not a reliable source for everyone as the
season, time of day, geography, latitude, level of air pollution, skin color, and age all affect our skin’s
ability to produce Vitamin D. Rickets and osteomalacia are actually the same condition; rickets is the
name used when it occurs in children with premature bones whereas osteomalacia is the term used
for adults with mature bones. Vitamin D and Uterine Fibroids—Review of the Literature and Novel
Concepts. OBJECTIVE: To determine whether modest elevations of fasting serum. This review
discusses studies on vitamin D status, Expanded Disability Status Scale (EDSS) score, and relapse
activity of MS. Furthermore, several considerations for intervention studies on vitamin D
supplementation in MS are provided. Griffin et al. recommend 4000 IU vitamin D per day for 1
month, followed by 800?1000 IU per day for maintenance in people at risk of VDD for prevention
of COVID-19. 207 This level of supplementation should also help prevent other RTIs. Summary of
the data: Of the 1475 studies, 09 were included. International Journal of Human Nutrition and
Functional Medicine 2014 Oct 3. Vasquez A. Translating Microbiome (Microbiota) and Dysbiosis
Research into Clinical Practice: The 20-Year Development of a Structured Approach that Gives
Actionable Form to Intellectual Concepts. Vitamin D levels should be monitored and vitamin D dose
adjusted accordingly, as studies have shown that obesity decreases the effect of vitamin D
supplementation. 11. OBJECTIVE: There are varied reports on the effect of vitamin D. On the other
hand, these therapies of this method are quite expensive and unlikely to everyone can afford it.
Nutritional rickets around the world: causes and future directions. They are believed to have a high
efficiency to absorb UV radiation and protect the organisms (Holick, 2009). However, Vitamin D2
(also called ergocalciferol) cannot be produced by vertebrates included Human and should be
obtained from external environment. If humans eat 3.6 oz of canned tuna, they can absorb 300 IU of
Vitamin D. Vitamin D influence on uterine fibroid (UF) pathophysiological pathways. Lancet 2:1222
(1922).; Steenbock, H. The induction of growth promoting and. Ciebiera M, Wlodarczyk M, Ciebiera
M, Zareba K, Lukaszuk K, Jakiel G. VDD is common in patients with IBD, although it is unclear
whether this is a cause or a consequence of the disease. 47.
Case group consumed 50,000 IU of vitamin D once a week for 12 weeks and control group placebo.
Looking at the individual study results of the most comprehensive meta-analysis that included 19
RCTs, 183 positive results, although not always statistically significant, appeared to be consistent
over a wide range of dosage regimens, with the exception of two studies that used 300 000 IU bolus
dosages and showed no effects. This trial used 60 000 IU every other week for 6 months, 74 whilst
two of the other studies used a monthly regimen of 100 000 IU and one a very low dose (40 IU per
day). Regular screening for Vitamin D deficiency may also be necessary, particularly in high-risk
populations. International College of Human Nutrition and Functional Medicine, 2014 5. Increasing
age and elevated body fat mass contribute to an increased risk of Vitamin D deficiency. Vasquez A,
Gilbert Manso, M.D., John Cannell, M.D. The Clinical Importance of Vitamin D (Cholecalciferol): A
Paradigm Shift with Implications for All Healthcare Providers. Histopathological variants of
squamous cell carcinoma (Doctor Faris Alabeedi. Another phase 3 clinical trial is currently underway
to confirm these results. 107. Even young children and young and middle-aged adults are at
significantly increased risk of vitamin D deficiency. Aim: To study the association between vitamin D
level and HbA1C level. Also, a highly significant decrease in the level of LDL. Annals of Tropical
Paediatrics: International Child Health, Volume 26, Number 1, March 2006, pp. 1-16(16). Journal of
Low Power Electronics and Applications (JLPEA). Low prenatal and perinatal maternal vitamin D
concentrations can affect the. The authors carried out various subgroup analyses, and found no
increase in AEs regardless of whether vitamin D was given with or without calcium, length of
supplementation, baseline vitamin D levels or whether vitamin D 2 or D 3 were used, a subgroup
analysis by dose of vitamin D was not reported. 208. Furthermore, Vitamin D3 is more effective than
Vitamin D2 in human since both duration and potency of Vitamin D3 are higher than that of Vitamin
D2 ( Laura et al.,2004 ). One of the most recently published studies on these correlations was
published in 2015. The major cause of vitamin D deficiency is the lack of appreciation that sun
exposure in moderation is the major source of vitamin D for most humans. Whilst dosages and
regimens have varied between studies, 4000 IU per day has been shown to be beneficial. 106. Whilst
there is some evidence of benefits for cardiovascular risk factors, this does not translate to a
reduction in cardiovascular events in clinical trials. Vitamin D is important for calcium absorption
and patients with a deficiency. RESULTS: Higher 25(OH)D(3) was significantly associated with a
reduced. Presentation on Cerebral Palsy and its orthotic management Presentation on Cerebral Palsy
and its orthotic management pediatrics. However, Vitamin D2 (also called ergocalciferol) cannot be
produced by vertebrates included Human and should be obtained from external environment.
Epidemiological studies continue to emphasize the role of vitamin D deficiency in the development
of UFs. Alternative Therapies in Health and Medicine 2004 6. Vitamin D, GnRH analogs and
SPRMs. According to Ali et al. Seasonal affective disorder (SAD) is a particular subtype of
depression. OBJECTIVE: The association of hypovitaminosis D with type 2 diabetes is well.
Elgar carried out the literature review and formulated the manuscript. Lancet 2:1222 (1922).;
Steenbock, H. The induction of growth promoting and. Increasing age and elevated body fat mass
contribute to an increased risk of Vitamin D deficiency. However, because people with obesity are at
increased risk for many conditions associated with VDD, supplementation should be considered,
especially in those with VDD. On the other hand, these therapies of this method are quite expensive
and unlikely to everyone can afford it. You can download the paper by clicking the button above.
Ciebiera, Michal, Marta Wlodarczyk, Magdalena Ciebiera, Kornelia Zareba, Krzysztof Lukaszuk,
and Grzegorz Jakiel. International Journal of Translational Medicine (IJTM). Vitamin D and Uterine
Fibroids—Review of the Literature and Novel Concepts. Nutritional rickets around the world:
causes and future directions. There is high prevalence of vitamin D deficiency in children with limb.
Foods like oily fish, eggs, fortified cereals and breads are all sources of vitamin D, but these may
still be inadequate when sunshine hours are limited. RAMOS, Valter Araga?o Goals: To verify
whether the use of Vitamin D as parallel therapy to hospital and drug treatment can be effective in
the process of infectious reduction in hospitalized children. MetS, its components (central obesity,
hypertension, low high-density. Molecular and Cellular Endocrinology 2004; 215: 31-38.; Helming
L, et al. Blood 2005; 106: 4351-4358; Abu-Amer Y, Bar-Shavit Z. We measured serum level of 25-
hydroxy vitamin D and compared them between the two groups.Results:We gathered 42 females and
8 males as case group and the same numbers as control group without significant age difference.
Aim: To study the association between vitamin D level and HbA1C level. CONCLUSIONS: Lower
serum 25(OH)D levels are associated with prediabetes. Methods: It was an analytical observational
case study. Vitamin D is synthetized in skin from 7-dehydrocholesterol. It is being prescribed very
frequently in clinical practice. Epidemiological studies continue to emphasize the role of vitamin D
deficiency in the development of UFs. Due to rare side effects and relatively high safety of vitamin
D, we could also consider combination therapies—drugs with additional simultaneous vitamin D
supplementation. Similarly, a meta-analysis just focussing on vitamin D intervention trials found that
vitamin D significantly improved progression-free survival and reduced adverse CRC outcomes by
30%, 105 with the best results seen in a study using 4000 IU per day for 23 months. 106 In the same
publication, a reduction in CRC incidence failed to reach statistical significance. METHODS: We
measured serum 25-OH D in 554 subjects. The main safety concern with vitamin D is
hypercalcaemia, based on its role in calcium metabolism, and caution is therefore advised in
conditions and with medications that can also affect calcium metabolism. Health Professionals
Follow-Up Study and the Nurses' Health Study showed. Journal of Theoretical and Applied
Electronic Commerce Research (JTAER). Vitamin D influence on uterine fibroid (UF)
pathophysiological pathways. There are other ways to explain the beneficial effects of vitamin D on
UFs.
Hodgkin lymphoma. He proposes that adequate exposure to ultraviolet. Vitamin D has direct effects
on both adaptive and innate immune systems. In. The present study was designed with the aim to
assess association among control, pre-diabetic and diabetic with vitamin D and association between
lipid profile and vitamin D. Median age was 74 (64-80) years, left ventricular ejection fraction was
30%. Elderly people are at high risk for vitamin D deficiency if their life style entails few outdoor
activities, their skin is thick and they exhibit impairment of renal function. Please note that many of
the page functionalities won't work as expected without javascript enabled. At the same time,
Vitamin D works with PTH (parathyroid hormone) as to regulate the release of calcium and
phosphorus from the bones into the bloodstream. Lack of randomized controlled trials on vitamin D
use in the prophylaxis or treatment of UFs remains a significant problem. Journal of Cardiovascular
Development and Disease (JCDD). There are several actions that could trigger this block including
submitting a certain word or phrase, a SQL command or malformed data. The consensus in this area
can bring tangible benefits to women with UFs. CAG demonstrated significant CAD in 70 patients
(35%). But Vitamin D deficiency can cause dematerialize the bone. Indian Journal of Endocrinology
and Metabolism 2011 Oct;15 Suppl 4:S395-. Normally, the BMD in the patient will increase
considerably and can prevent vertebral fractures. In addition, avoiding a status of vitamin D
deficiency to obtain its positive effects on the immune system and its protective mechanism during
infections will be a general benefit overall. This review aimed to determine whether there is evidence
to recommend the use of vitamin D as monotherapy or as adjunct therapy in patients with MS. We
searched PUBMED, EMBASE, COCHRANNE, and LILACS databases for studies published until
September 9 th, 2013, using the keywords “multiple sclerosis”, “vitamin D”, and “clinical trial”.
Bursitis is inflammation or irritation of a bursa sac. Due to rare side effects and relatively high safety
of vitamin D, we could also consider combination therapies—drugs with additional simultaneous
vitamin D supplementation. Two hydroxylation reactions for the Vitamin D prohormones for
activation, the first hydroxylation takes place in the liver and intermediate called 25-hydroxyvitamin
D (also called Calcidiol) are formed. Affective (Mood) Disturbances - In patients with fibromyalgia
syndrome. RESEARCH DESIGN AND METHODS: We investigated the association among. A
number of observational studies have investigated whether people. The aim of the review was to
evaluate the current state of knowledge about the role of vitamin D in uterine fibroid biology and
management. Several countries have published recommendations for the dietary intake of vitamin D
(Annex 5). They ar e common manifestations of Vitamin D deficiency relating to other pathologic
conditions in all ages. The aforementioned clinical trials using vitamin D in a wide range of. For
middle-aged women, selective oestrogen receptor modulators (SERM) can be very efficient. Latin
American and Caribbean Health Sciences (Lilacs), Scopus and Web of Science. It also reviews, in
short, the role of vitamin D and the impact of its deficiency in several infections namely tuberculosis,
influenza, human immunodeficiency virus (HIV), and SARS-CoV-2.
You can download the paper by clicking the button above. The action you just performed triggered
the security solution. Early prevention, appropriate prophylaxis, as well as treatment of UFs at an
early stage in high-risk women, are priority actions. However, because people with obesity are at
increased risk for many conditions associated with VDD, supplementation should be considered,
especially in those with VDD. Symptoms include fatigue, visual disturbances (through affecting the
optic nerve), paraesthesia (abnormal sensation of the skin), muscle spasms, weakness and stiffness,
pain and mobility problems, and can lead to severe disability. Hypovitaminosis D is associated with
insulin resistance and beta-cell. Summary of the data: Of the 1475 studies, 09 were included. Journal
of Experimental and Theoretical Analyses (JETA). Also, a highly significant decrease in the level of
LDL. The results of the available studies, published in English from January 2002 up to April 2018,
have been discussed. In the present review, the most relevant features of vitamin D are described as
well as the clinical consequences of hypovi-taminosis D in the elderly. Individuals with the highest
vitamin D intakes (more than 16 ?g, or 645 IU. Journal of Otorhinolaryngology, Hearing and
Balance Medicine (JOHBM). IJAR Indexing Background- Vitamin D3 is known for its calcium
absorption and bone metabolism; but now been recognized as an accessible predictor, risk factor and
biomarker of type 2 diabetes mellitus (T2DM). In today’s world ultraviolet light from the sun may
be blocked by air. Mealy, RN, BSN, and colleagues report a retrospective analysis of vitamin D.
Fleming, and Picard prescribed daily supplementation with. International Journal of Human
Nutrition and Functional Medicine 2014 Oct 3. Vasquez A. Translating Microbiome (Microbiota) and
Dysbiosis Research into Clinical Practice: The 20-Year Development of a Structured Approach that
Gives Actionable Form to Intellectual Concepts. Recent evidence has indicated that vitamin D also
plays an essential role in the immune response against viral infections and suggested that vitamin D
deficiency increases susceptibility to viral infections as well as the risk of recurrent infections.
DEXA scans, however, only measure BMD and do not assess the structural micro-architecture of the
bone tissue, and therefore may not accurately reflect risk of fractures. 88 There are well over 50
RCTs looking into the role of vitamin D either alone or with calcium in osteoporosis. Vitamin D and
Uterine Fibroids—Review of the Literature and Novel Concepts. A wide range of dosages appeared
to be beneficial, except large bolus doses. What is already known is that UFs regulate and stimulate
the accumulation of ECM, with TGF-. Diet, supplements and sunlight are the major source of
vitamin D in humans. Quigley recently showed that 93% of their 150 patients with persistent. Study
who were free of clinical cardiovascular disease at baseline. We. Nutritional rickets around the world:
causes and future directions. It also has a role in regulating cell proliferation and differentiation.7-
Dehydrocholesterol (an intermediate in the synthesis of cholesterol that accumulates in the skin)
undergoes a non-enzymatic reaction on exposure to ultraviolet light, yielding pre-vitamin D. Foods
like oily fish, eggs, fortified cereals and breads are all sources of vitamin D, but these may still be
inadequate when sunshine hours are limited. RESEARCH DESIGN AND METHODS: We
investigated the association among.
CAG demonstrated significant CAD in 70 patients (35%). Perhaps it could be more effective than
the traditional approach in patients with the most severe symptoms, such as in obese African-
Americans with vitamin D deficiency. London 1-373 (1668).; Mellanby, E. and Cantag, M.D.
Experimental investigation on rickets. Current best evidence demonstrates that supplemental vitamin
D can. Migraine Headaches -There have been case reports of vitamin D combined. In the same year,
Halder et al., published a study which showed the effect of vitamin D3 on the transforming growth
factor beta (TGF-?) pathway. MetS, its components (central obesity, hypertension, low high-density.
Recently, many experts and professional associations have recommended an increase in the Vitamin
D intake from 200IU (5g) to 1000IU (25g) for an adult. In cases of deficiency of vitamin D there is
not only a decreased secretion of insulin but also increased insulin resistance as proved by various
studies. Vitamin D is synthetized in skin from 7-dehydrocholesterol. The results of the available
studies, published in English from January 2002 up to April 2018, have been discussed. Three recent
clinical trials also showed improvements in a number of fertility-related markers 178,179,180 and
pregnancy rates. 180. Only 2% of patients on calcifediol needed transfer to the ICU and none of
them died, compared with two deaths (8%) and 50% of patients needing ICU treatment in the
control group. 202 This raises the question, whether the use of an activated form of vitamin D may
provide more benefit in acutely and severely ill patients in whom activation of vitamin D 3 may be
impaired or take too long. Nevertheless, these recommendations differ depending on the source,
reflecting variations in the approach to providing general dietary guidelines. The synergy between
vitamin D and selected anti-UF drugs is a very interesting issue which requires further research.
Whilst dosages and regimens have varied between studies, 4000 IU per day has been shown to be
beneficial. 106. Methodology: We conducted a comprehensive literature search using academic
databases, including PubMed, MEDLINE, Scopus, and Google Scholar. Prediabetes (PreDM) and
prehypertension (PreHTN) were diagnosed using. New data about between vitamin D, vitamin D
analogs and other mostly used drugs in UF therapy is necessary to find other synergisms.
Gonadotropin releasing hormone (GnRH), selective progesterone receptor modulator (SPRM). As
immune cells in infected patients are responsive to the ameliorative effects of vitamin D, the
beneficial effects of supplementing vitamin D-deficient individuals with an infectious disease may
extend beyond the impact on bone and calcium homeostasis. Bursitis is inflammation or irritation of
a bursa sac. Dietary Supplement Fact Sheet: Vitamin D, Office of Dietary Supplements. See Full
PDF Download PDF About Press Blog People Papers Topics Job Board We're Hiring. In another
study, the European Prospective Investigation into Cancer and. Study who were free of clinical
cardiovascular disease at baseline. We. People with old age, dark skinned and obese cannot produce
sufficient amount of Vitamin D. Unfavorable metabolic profiles and oxidative stress in pregnancy
are. According to The American Diabetes Association (ADA), and World Health Organization
(WHO), HbA1c concentrations 6.5% or more is diagnostic of diabetes. However, it is not
recommended for menopausal women since it has risks from causing breast cancer. International
Journal of Human Nutrition and Functional Medicine 2014 Oct 3. Vasquez A. Translating
Microbiome (Microbiota) and Dysbiosis Research into Clinical Practice: The 20-Year Development
of a Structured Approach that Gives Actionable Form to Intellectual Concepts.