Professional Documents
Culture Documents
Laniyati Hamijoyo
Rheumatology Division
Departement of Interal medicine
Universitas Padjadjaran/ Hasan Sadikin Hospital
Bandung Indonesia
Lani Hamijoyo
Allergy
§ Type of hypersensi2vity reac2ons of the immune system. Allergy may
involve more the one type of reac2on.
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Allergy
Risk factor
§Host factors; heredity, gender, race, and age.
§ Environmental factor; infectious diseases during early
childhood, environmental pollution, allergen levels
and dietary changes.
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Figure 10-1
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Hypersensi-vity
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Hypersensitivity reactions
• 4 main hypersensi2vi2es (I-IV)
– Type I Anaphalaxis; Immediate; IgE mediated mast
cell degranula2on
• Allergies, atopy
– Type II Cytotoxic (IgM and IgG mediated)
• autoimmune hemoly2c anemia, pemphigus vulgaris
– Type III Immune complex
• Serum sickness, RA, SLE
– Type IV DTH/contact sensi2vity
• Contact derma22s
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Type of Hypersensi2vity
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Hypersensi-vity Reac-ons
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Allergy
Ig E mediated (Type I
hypersensitivity)
Allergy
Non Ig E mediated
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IgE Mediated: Type I
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Atopy
§ Atopy is the genetic predisposition to make IgE antibodies
in response to allergen exposure.
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Common allergens associated with type I hypersens2vity
§ Proteins § Foods
q Foreign serum q Nuts
q Vaccines q Seafood
§ Plant pollens q Eggs
q Rye grass q Peas, beans
q Ragweed q Milk
q Timothy grass § Insect products
q Birch trees q Bee venom
§ Drugs q Wasp venom
q Penicillin q Ant venom
q Sulfonamides q Cockroach calyx
q Local anethe2cs q Dust mites
q Salicylates § Mold spores
q Animal hair and dander
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Immuno
pathogenesis
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Mast Cell
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Mast Cell Ac-va-on
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Performed Mediators/ Primary Mediators
Histamine:
This mediator acts on histamine 1(H1) and histamine 2 (H2) receptors to
cause:
- contraction of smooth muscles of the airway and GI tract,
- increased vascular permeability and vasodilation,
- nasal mucus production, airway mucus production,
- pruritus,
- cutaneous vasodilation, and gastric acid secretion.
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Performed Mediators/ Secondary Mediators
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Important Clinical Aspects of Immediate
Hypersensitivity
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Comparison of Allergy with other Responses
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Laboratory Diagnosis
Skin Tests
IgE-Mediated
Allergies
Blood Tests
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Skin Tests
§ The cutaneous test
§ (prick test, puncture test epicutaneous test)
§ Routine diagnosis in diseases (atopic or anaphylactic).
§ A single drop of concentrated aqueous allergen extract
placed on the skin which is then pricked lightly with a
needle point at the center of the drop. After 20 minutes the
reaction is graded and recorded
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Laboratory Tests
§ IgE levels may be elevated in patients who are atopic,
but the level does not necessarily correlate with
clinical symptoms.
§ The tryptase level can be elevated, which is indicative
of mast cell degranulation. False-negative results can
occur.
§ An elevated eosinophil count may be observed in
patients with atopic disease.
§ RAST/CAP RAST/CAP FEIA (fluorenzymeimmunoassay):
measures antigen-specific IgE.
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Nasal smear/ Spirometry
§ Nasal smear
§ Elevated eosinophil levels can be consistent with
allergic rhinitis.
§ Spirometry or pulmonary function tests
§ offer an objective means of assessingasthma. Peak-
flow meters can also be used for this and can be
used by patients at home to monitor their status
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Standardized diagnostic allergens are not available for drugs
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Prevention
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Treatment
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Allergic Reactions
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Allergic Reactions
Anaphylactoid reac-on :
Syndrome presen-ng similar to anaphylaxis, expressed by similar
mediators, but not triggered by IgE & not necessarily due to prior
exposure to the inci-ng agent
Ur-caria :
Diffuse patchy erythematous pruri-c rash with raised borders
Angioedema :
Non-piWng subcutaneous -ssue swelling
OKen of the face, mouth, or peri-airway -ssue
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Case: Angioedema Due to ACE Inhibitors
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Severe angioedema
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Same patient on prior
slide after treatment
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Clinical Manifestations of Systemic
Allergic Reactions
• Diffuse pruri-s, ur-caria, angioedema, erythroderma
• Anxiety, dizziness, sense of doom, altered mental status
• Dyspnea, stridor, wheezing
• Dysphagia, dysarthria, drooling
• Vomi-ng, diarrhea, abd. cramps
• Urinary incon-nence
• Hypotension +/- bradycardia
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Differential Dx of Severe Allergic Reaction
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Management of Systemic Allergic Reactions
• May progress rapidly & unpredictably, all patients. with
possible systemic reaction should be rapidly triaged to
acute care room & continuously monitored
• Suggested initial sequence :
• O2 / airway management
• SQ or IM epi (0.01 mg/kg or max. 0.3 mg in adults)
• IV placement ; IV fluid bolus (NS) if hypotensive
• IV diphenhydramine & IV steroids
• Beta 2 aerosol if wheezing
• Secondary meds ; consider repeat epi doses
• Remove source of reaction if possible
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Airway Management Considerations for
Severe Allergic Reactions
• Swelling impinging the airway may progress rapidly so
earlier intuba-on more likely successful than later
• Consider seda-on without paralysis if an-cipated difficulty
• Start with ETT size one size smaller than usual
• Have surgical airway equipment at bedside
• Place nasal airway early even if ETT not ini-ally required
• Consider use of inhaled racemic epi
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Potential Complications of Use of Epi for
Allergic Reactions
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Epi Doses for Allergic Reactions
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Antihistamine Med Rx for Allergic Reactions
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Steroid Rx for Allergic Reactions
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Summary
• 4 types of Hypersensi2vity reaac2on
• Allergy is IgE mediated and non IgE mediated
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