ANGIOTENSIN CONVERTING ENZUME :

Converts inactive
Angiotensin I to active
Angiole usin I
role ep
inte
-

t active
Degrades bradykinin make
·
role in renal development ,

&
infertility , hematopoiesis ;
and
erythropoiesis ,
myelopoesis mmune
response
Hypertensive patients
ACE2 levels are

ASE I :
Angiotension It to
Angiotension (1-1) lower in both

kidneyshe
also connects
Angiotension I to Angiotensin (1-9)
: ACE2 favours the balance of Ang(1-7) onea
Ang II
:
cardioprotective sole of ACEC via
Ang (1-7)/mas signalling
Pathway
Isoenzymes
>
- Somatic ACE

Testicular ACE Molecular structure

>
-

domains
ze metalloproteinase
Chimaera
· Two
catalytic
ACEI
protein
·

single catalytic
domain
N-domain
C-domain & testicular C-domaini
ACE

c-lesminal resembles collectic C-terminal transmembrane

-
·

This act as a chaperone protein segment (stalk)

may
to deliver other
protein to
brush border membrane
.

ACE : Ch
1Fg23
ACE2 : Ch Xp22

Expression Abundan in

Somatic ACE
extremely
Vascular
organs ,
- blood vessels >
-
lungs
-
highest amount)
>
-
kidney >
- relma
>
- intestines
ACE2

-adrenal
>
-

lever gland
>
-

>
-
lung
lever
-
uterus >
- intestime
-
testis
Testicular ACE >
- brain
heart
portnciotic male alls >
-
>
-
germ -

kidney
Expression of ACE
affected by
>
- Steroids

thyroid hormones
>
-

HIF-1x :
promotes regulator of ACE
conditions
upregulates ACE
expression
under
hypoxic
II concentration
..

Angiotensin
ACE2 :
downregulated by hyposia
controlled
by angiotensi I (not HIF-14)

Angiotensinogen
renin

>
Aug 1 9
-

Angiotensi
I
-

↑ -ACE
-
ACE ACEL ↓
Ang 1 5
-

&
Angiotensi I -

Ang 1-7

A
e
ACE In SARCOIDOSIS

epithelioid cells from decined

Is
produced by
activated macrophages known :
marker
for sarcoidosis
a correlates with the amount of whole-body granuloma
the lungs
(not ones
found in
only)
-
disease severity

disease disease
granulomatous
alw levels
non-
granulomatous
alw PACE levels :
PACE
:

·
leprosy
-
hyperthyrodsin
·
histoplasmosis -
Lymphoma