Crafting a Literature Review on Nigella Sativa

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It also reduced lung injury, and IL-17 (inflammatory protein). The in vitro analysis of these
combinations demonstrated that these combinations digested the S-1 and S-2 subunits of the spike
protein of SARS-CoV-2 and attenuated it. International Journal of Environmental Research and
Public Health (IJERPH). The published results of another CT (NCT04347382) affirmed that the
combination of honey and NSO improved the COVID-19 symptoms, viral clearance, and mortality
among COVID-19 patients. Conflicts of Interest The authors declare no conflict of interest. It is an
effective chemotherapeutic agent against breast, bladder, cervical, colorectal, gastric, lung, prostate,
pancreatic cancers, and leukemia in vitro and in vivo studies. Multiple requests from the same IP
address are counted as one view. Surprisingly, TQ was identified as a lead compound in only one in
silico and one in vitro study. NS seeds, owing to their peculiar aroma, fragrance, and nutritional
value, are also used as food additives. Gout, Urate, and Crystal Deposition Disease (GUCDD).
Scientists have been identifying remedies for its prevention and treatment from all possible sources,
including plants. Editor’s Choice articles are based on recommendations by the scientific editors of
MDPI journals from around the world. Summary of several in silico, in vitro, and in vivo
investigations carried out on NS chemical constituents against COVID-19. Journal of Cardiovascular
Development and Disease (JCDD). Two CTs were related to the prevention of COVID-19, whereas
six CTs involved treatment of COVID-19 utilizing NS. The available facts indicate that NS, NSO,
and its various compositions have all the attributes to be used as a promising remedy to prevent,
manage, and treat COVID-19 among high-risk people as well as for the therapy of COVID-19
patients of all age groups as a monotherapy or a combination therapy. Imran M, Khan SA, Abida,
Alshammari MK, Alkhaldi SM, Alshammari FN, Kamal M, Alam O, Asdaq SMB, Alzahrani AK.
One of the published clinical studies (NCT04401202) concluded that NSO supplementation provides
faster recovery of 62% of the mild COVID-19 patients on day 14 of the treatment. The literature
was collected from different databases, including Pubmed, Espacenet, and Patentscope. The patent
applications that exclusively provide clear information about the use of N. Find support for a specific
problem in the support section of our website. Please note that many of the page functionalities won't
work as expected without javascript enabled. Please let us know what you think of our products and
services. The in vivo activity data demonstrated that the claimed composition enhanced type 2
monocytes, IL-10 (anti-inflammatory protein), and HGF-1 (regenerative protein). Feature papers
represent the most advanced research with significant potential for high impact in the field. A
Feature. All articles published by MDPI are made immediately available worldwide under an open
access license. No special. Data presented in Table 1 indicate that four in silico studies identified ?-
Hederin as the promising anti-COVID agent while DTQ in one in vitro and three in silico studies
emerged as the lead anti-viral candidate. Error: Try Again Ok Sell Watchlist Expand Watch List
Loading. ISPRS International Journal of Geo-Information (IJGI). Therapeutic properties of NS and
its chemical components.
Surprisingly, TQ was identified as a lead compound in only one in silico and one in vitro study.
Imran, Mohd, Shah Alam Khan, Abida, Mohammed Kanan Alshammari, Saif M. Journal of
Otorhinolaryngology, Hearing and Balance Medicine (JOHBM). The patent application provides a
pictorial mechanism of action of the NS extract to treat COVID-19. Journal of Manufacturing and
Materials Processing (JMMP). Imran, Mohd, Shah Alam Khan, Abida, Mohammed Kanan
Alshammari, Saif M. Two CTs were related to the prevention of COVID-19, whereas six CTs
involved treatment of COVID-19 utilizing NS. International Journal of Turbomachinery, Propulsion
and Power (IJTPP). Find support for a specific problem in the support section of our website.
Acknowledgments The authors extend their appreciation to the Deputyship for Research and
Innovation, Ministry of Education, Saudi Arabia, for funding this work through the project number
IF-2020-NBU-215. Capsule-1 and capsule-2 were administered to patients two times a day and the
polyherbal decoction two times a day along with the standard care. Despite the development of
many vaccines and some drugs, the battle against COVID-19 is far from over. The patent
applications that exclusively provide clear information about the use of N. Many compositions of NS
in combination with many medicinal herbs and medicines are still unexplored. Please note that many
of the page functionalities won't work as expected without javascript enabled. First composition for
patients Terminalia chebula (TC). Please let us know what you think of our products and services. Its
nutritional value and a wide array of therapeutic properties have been known to mankind since
ancient times. Editors select a small number of articles recently published in the journal that they
believe will be particularly. Available online: (accessed on 1 April 2022). Imran, M.; Alshrari, S.A.;
Thabet, H.K.; Abida Bakht, A.M. Synthetic molecules as DprE1 inhibitors: A patent review.
Conflicts of Interest The authors declare no conflict of interest. It is disclosed that TQ may bind the
hydrophobic component of SARS-CoV-2 because of its lipophilicity. Journal of Cardiovascular
Development and Disease (JCDD). The published results of another CT (NCT04347382) affirmed
that the combination of honey and NSO improved the COVID-19 symptoms, viral clearance, and
mortality among COVID-19 patients. Amongst thousands of ethnomedicinal plants which are known
to be effective against infectious diseases and alleviate acute respiratory symptoms, N. Paper should
be a substantial original Article that involves several techniques or approaches, provides an outlook
for. Scientists have been identifying remedies for its prevention and treatment from all possible
sources, including plants. It also reduced lung injury, and IL-17 (inflammatory protein).
Compositions and Methods for Treating or Preventing Inflammatory Diseases Including Diabetes
Mellitus 10 Type I and Type II and Thyroid Diseases. The review and final editing of the manuscript
was carried out by M.I., S.M.B.A., A.K.A. and S.J. The supervision of the manuscript writing was
performed by M.I. and S.A.K. All authors have read and agreed to the published version of the
manuscript.
It is acceptably recognized that immunocompromised patients with little levels of natural killer cells,
interferon, and dendritic cells are vulnerable to SARS-CoV-2 infection. European Journal of
Investigation in Health, Psychology and Education (EJIHPE). Error: Try Again Ok Sell Watchlist
Expand Watch List Loading. Mechanism of action of NS and its chemical constituents against
SARS-CoV-2. NS seeds, owing to their peculiar aroma, fragrance, and nutritional value, are also
used as food additives. The clinical features of COVID-19 are similar to normal flu (cough, sore
throat, high fever, headache, sneezing, myalgia, breathlessness, etc.), and it mainly targets the
respiratory system, leading to acute respiratory distress syndrome. Alkhaldi, Fayez Nafea
Alshammari, Mehnaz Kamal, Ozair Alam, Syed Mohammed Basheeruddin Asdaq, A. We use cookies
on our website to ensure you get the best experience. Nigella sativa L. (NS) is an important
medicinal plant of Islamic value. The normal revival time was also briefer than the control group.
Many preparations of NS seeds, seed oil, and extracts containing varying amounts of thymoquinone
(TQ), either alone or in combination with other herbal products in capsule, powder, soft gels, and oil
forms, are also available on the market. Therapeutic properties of NS and its chemical components.
International Journal of Environmental Research and Public Health (IJERPH). NS can prevent and
treat COVID-19 patients with a faster recovery rate. It also reduced lung injury, and IL-17
(inflammatory protein). Journal of Manufacturing and Materials Processing (JMMP). The in vivo
activity data demonstrated that the claimed composition enhanced type 2 monocytes, IL-10 (anti-
inflammatory protein), and HGF-1 (regenerative protein). Surprisingly, TQ was identified as a lead
compound in only one in silico and one in vitro study. Subscribe to receive issue release notifications
and newsletters from MDPI journals. The nutritional value of black seed is due to its rich content of
vegetable proteins and amino acids, fats, fibers, carbohydrates, minerals, and vitamins. The literature
supports the efficacy of NS, NS oil (NSO), and its chemical constituents against COVID-19. Journal
of Theoretical and Applied Electronic Commerce Research (JTAER). Available online: (accessed on
1 April 2022). Imran, M.; Alshrari, S.A.; Thabet, H.K.; Abida Bakht, A.M. Synthetic molecules as
DprE1 inhibitors: A patent review. For more information on the journal statistics, click here. Editors
select a small number of articles recently published in the journal that they believe will be
particularly. One of the published clinical studies (NCT04401202) concluded that NSO
supplementation provides faster recovery of 62% of the mild COVID-19 patients on day 14 of the
treatment. The available facts indicate that NS, NSO, and its various compositions have all the
attributes to be used as a promising remedy to prevent, manage, and treat COVID-19 among high-
risk people as well as for the therapy of COVID-19 patients of all age groups as a monotherapy or a
combination therapy. The patent literature cites NS as an immunomodulator, antioxidant, anti-
inflammatory, a source of anti-SARS-CoV-2 compounds, and a plant having protective effects on the
lungs. Journal of Pharmaceutical and BioTech Industry (JPBI). ISPRS International Journal of Geo-
Information (IJGI).
European Journal of Investigation in Health, Psychology and Education (EJIHPE). Journal of
Pharmaceutical and BioTech Industry (JPBI). The composition is claimed to reduce the expression of
inflammatory markers in the human body. Multiple requests from the same IP address are counted as
one view. The normal revival time was also briefer than the control group. Available online:
(accessed on 1 April 2022). Imran, M.; Alshrari, S.A.; Thabet, H.K.; Abida Bakht, A.M. Synthetic
molecules as DprE1 inhibitors: A patent review. The patent application provides a pictorial
mechanism of action of the NS extract to treat COVID-19. Many preparations of NS seeds, seed oil,
and extracts containing varying amounts of thymoquinone (TQ), either alone or in combination with
other herbal products in capsule, powder, soft gels, and oil forms, are also available on the market.
Editors select a small number of articles recently published in the journal that they believe will be
particularly. Accessibility, User Agreement, Privacy, Payments Terms of Use, Cookies, CA Privacy
Notice, Your Privacy Choices and AdChoice. The clinical features of COVID-19 are similar to
normal flu (cough, sore throat, high fever, headache, sneezing, myalgia, breathlessness, etc.), and it
mainly targets the respiratory system, leading to acute respiratory distress syndrome. This
composition is said to possess anti-inflammatory activity and improves immunity by inhibiting the
expression of indoleamine 2,3-dioxygenase. Capsule-1 and capsule-2 were administered to patients
two times a day and the polyherbal decoction two times a day along with the standard care. Error:
Try Again Ok Sell Watchlist Expand Watch List Loading. Compositions and Methods for Treating
Solid and Soft Tumors and Proliferative Diseases. Scientists have been identifying remedies for its
prevention and treatment from all possible sources, including plants. Journal of Low Power
Electronics and Applications (JLPEA). Nigella sativa L. (NS) is an important medicinal plant of
Islamic value. Compositions and Methods for Treating and Preventing a Coronavirus Infection.
Summary of several in silico, in vitro, and in vivo investigations carried out on NS chemical
constituents against COVID-19. In order to be human-readable, please install an RSS reader. It is an
effective chemotherapeutic agent against breast, bladder, cervical, colorectal, gastric, lung, prostate,
pancreatic cancers, and leukemia in vitro and in vivo studies. Amongst thousands of ethnomedicinal
plants which are known to be effective against infectious diseases and alleviate acute respiratory
symptoms, N. Its nutritional value and a wide array of therapeutic properties have been known to
mankind since ancient times. Data presented in Table 1 indicate that four in silico studies identified ?-
Hederin as the promising anti-COVID agent while DTQ in one in vitro and three in silico studies
emerged as the lead anti-viral candidate. Visit our dedicated information section to learn more about
MDPI. International Journal of Environmental Research and Public Health (IJERPH). The CTs have
also been done using a combination of NS and honey or Omega 3. Compositions and Methods for
Treating and Preventing Non-Malignant Respiratory Disease. Next Article in Journal Extract from
Black Soybean Cultivar A63 Extract Ameliorates Atopic Dermatitis-like Skin Inflammation in an
Oxazolone-Induced Murine Model.
International Journal of Environmental Research and Public Health (IJERPH). The review and final
editing of the manuscript was carried out by M.I., S.M.B.A., A.K.A. and S.J. The supervision of the
manuscript writing was performed by M.I. and S.A.K. All authors have read and agreed to the
published version of the manuscript. Mechanism of action of NS and its chemical constituents
against SARS-CoV-2. The CTs have also been done using a combination of NS and honey or Omega
3. Accessibility, User Agreement, Privacy, Payments Terms of Use, Cookies, CA Privacy Notice,
Your Privacy Choices and AdChoice. Previous Article in Journal Gene Interaction Network Analysis
Reveals IFI44L as a Drug Target in Rheumatoid Arthritis and Periodontitis. Two CTs have been
conducted in Saudi Arabia, two in Pakistan, two in Tunisia, and one each in the United States, and
Egypt. Visit our dedicated information section to learn more about MDPI. All these facts indicate
that NS and its various compositions have all the attributes to be used as a promising remedy for the
management of COVID-19 among high-risk individuals as well as to treat normal COVID-19
patients as a monotherapy or a combination therapy. Summary of several in silico, in vitro, and in
vivo investigations carried out on NS chemical constituents against COVID-19. The literature was
collected from different databases, including Pubmed, Espacenet, and Patentscope. Mechanism of
action of NS and its chemical constituents against SARS-CoV-2. Gout, Urate, and Crystal
Deposition Disease (GUCDD). Many in silico, in vitro, and in vivo studies have demonstrated
potential anti-COVID-19 activity of the main chemical constituents of NS due to their diverse
mechanisms of action against SARS-CoV-2 ( Table 1 ) ( Figure 3 ). The available facts indicate that
NS, NSO, and its various compositions have all the attributes to be used as a promising remedy to
prevent, manage, and treat COVID-19 among high-risk people as well as for the therapy of COVID-
19 patients of all age groups as a monotherapy or a combination therapy. Chemical structure of the
main bioactive constituents of N. sativa L. against COVID-19. Alkhaldi, Fayez Nafea Alshammari,
Mehnaz Kamal, Ozair Alam, Syed Mohammed Basheeruddin Asdaq, A. All these facts, in
combination with the data of the CTs based on NS, indicate the potential of NS for the management
of COVID-19 in normal COVID-19 patients as well as among the high-risk population. Please let us
know what you think of our products and services. It is acceptably recognized that
immunocompromised patients with little levels of natural killer cells, interferon, and dendritic cells
are vulnerable to SARS-CoV-2 infection. Its nutritional value and a wide array of therapeutic
properties have been known to mankind since ancient times. The clinical features of COVID-19 are
similar to normal flu (cough, sore throat, high fever, headache, sneezing, myalgia, breathlessness,
etc.), and it mainly targets the respiratory system, leading to acute respiratory distress syndrome. The
composition is claimed to reduce the expression of inflammatory markers in the human body. The
patent application provides a pictorial mechanism of action of the NS extract to treat COVID-19.
Compositions and Prevention and Intervention Methods for COVID-19 with Divine Ayats’ Fitra30
COVID-19 Protocol. All articles published by MDPI are made immediately available worldwide
under an open access license. No special. Editor’s Choice articles are based on recommendations by
the scientific editors of MDPI journals from around the world. The nutritional value of black seed is
due to its rich content of vegetable proteins and amino acids, fats, fibers, carbohydrates, minerals,
and vitamins. Journal of Functional Morphology and Kinesiology (JFMK). Please note that many of
the page functionalities won't work as expected without javascript enabled.
Tropical Medicine and Infectious Disease (TropicalMed). The patent application provides a pictorial
mechanism of action of the NS extract to treat COVID-19. The patent searching was performed
utilizing different patent databases (Sci-Finder, Espacenet, Patentscope, and USPTO). Compositions
and Methods for Treating and Preventing Non-Malignant Respiratory Disease. NS can prevent and
treat COVID-19 patients with a faster recovery rate. The published results of another CT
(NCT04347382) affirmed that the combination of honey and NSO improved the COVID-19
symptoms, viral clearance, and mortality among COVID-19 patients. It is an effective
chemotherapeutic agent against breast, bladder, cervical, colorectal, gastric, lung, prostate, pancreatic
cancers, and leukemia in vitro and in vivo studies. Available online: (accessed on 1 April 2022).
Imran, M.; Alshrari, S.A.; Thabet, H.K.; Abida Bakht, A.M. Synthetic molecules as DprE1 inhibitors:
A patent review. All these facts, in combination with the data of the CTs based on NS, indicate the
potential of NS for the management of COVID-19 in normal COVID-19 patients as well as among
the high-risk population. Find support for a specific problem in the support section of our website.
NS seeds, owing to their peculiar aroma, fragrance, and nutritional value, are also used as food
additives. The clinical studies and patent filings support the therapeutic efficacy of NS against
COVID-19 owing to its immunomodulatory, antioxidant, antiviral, and anti-inflammatory effects.
Journal of Low Power Electronics and Applications (JLPEA). In order to be human-readable, please
install an RSS reader. Paper should be a substantial original Article that involves several techniques or
approaches, provides an outlook for. It is disclosed that TQ may bind the hydrophobic component of
SARS-CoV-2 because of its lipophilicity. The clinical data imply that NS and NSO can prevent and
treat COVID-19 patients with a faster recovery rate. Journal of Theoretical and Applied Electronic
Commerce Research (JTAER). Journal of Experimental and Theoretical Analyses (JETA). Herbal
Anti-Viral Drug Containing Black Seed Oil for Treating Coronavirus Disease (COVID-19).
Mechanism of action of NS and its chemical constituents against SARS-CoV-2. Gout, Urate, and
Crystal Deposition Disease (GUCDD). International Journal of Environmental Research and Public
Health (IJERPH). Editor’s Choice articles are based on recommendations by the scientific editors of
MDPI journals from around the world. Institutional Review Board Statement Not applicable.
Accordingly, the authors foresee a bright scope in developing NS-based anti-COVID-19 composition
for clinical use in the future. Two CTs have been conducted in Saudi Arabia, two in Pakistan, two in
Tunisia, and one each in the United States, and Egypt. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
). Visit our dedicated information section to learn more about MDPI.
Compositions and Methods for Treating or Preventing Inflammatory Diseases Including Diabetes
Mellitus 10 Type I and Type II and Thyroid Diseases. The in vivo activity data demonstrated that the
claimed composition enhanced type 2 monocytes, IL-10 (anti-inflammatory protein), and HGF-1
(regenerative protein). In order to be human-readable, please install an RSS reader. Compositions and
Methods for Treating Solid and Soft Tumors and Proliferative Diseases. The patent literature cites
NS as an immunomodulator, antioxidant, anti-inflammatory, a source of anti-SARS-CoV-2
compounds, and a plant having protective effects on the lungs. The patent applications that
exclusively provide clear information about the use of N. Please note that many of the page
functionalities won't work as expected without javascript enabled. Chemical structure of the main
bioactive constituents of N. sativa L. against COVID-19. Despite the development of many vaccines
and some drugs, the battle against COVID-19 is far from over. Tropical Medicine and Infectious
Disease (TropicalMed). The chemical structure of selected important bioactive components of NS is
presented in Figure 2. Mechanism of action of NS and its chemical constituents against SARS-CoV-
2. Chemical structure of the main bioactive constituents of N. sativa L. against COVID-19. It is a
well-known fact that thrombus formation causes multiple organ collapse and fatality among COVID-
19 patients. Nigella sativa L. (NS) is an important medicinal plant of Islamic value. Previous Article
in Journal Gene Interaction Network Analysis Reveals IFI44L as a Drug Target in Rheumatoid
Arthritis and Periodontitis. The CTs have also been done using a combination of NS and honey or
Omega 3. Feature papers represent the most advanced research with significant potential for high
impact in the field. A Feature. Compositions and Methods for Treating and Preventing a Coronavirus
Infection. Editors select a small number of articles recently published in the journal that they believe
will be particularly. It is acceptably recognized that immunocompromised patients with little levels of
natural killer cells, interferon, and dendritic cells are vulnerable to SARS-CoV-2 infection. Data
presented in Table 1 indicate that four in silico studies identified ?-Hederin as the promising anti-
COVID agent while DTQ in one in vitro and three in silico studies emerged as the lead anti-viral
candidate. ISPRS International Journal of Geo-Information (IJGI). All articles published by MDPI
are made immediately available worldwide under an open access license. No special. Journal of
Theoretical and Applied Electronic Commerce Research (JTAER). The review and final editing of
the manuscript was carried out by M.I., S.M.B.A., A.K.A. and S.J. The supervision of the manuscript
writing was performed by M.I. and S.A.K. All authors have read and agreed to the published version
of the manuscript. Compositions and Prevention and Intervention Methods for COVID-19 with
Divine Ayats’ Fitra30 COVID-19 Protocol. The available facts indicate that NS, NSO, and its
various compositions have all the attributes to be used as a promising remedy to prevent, manage,
and treat COVID-19 among high-risk people as well as for the therapy of COVID-19 patients of all
age groups as a monotherapy or a combination therapy. Surprisingly, TQ was identified as a lead
compound in only one in silico and one in vitro study. The literature supports the efficacy of NS, NS
oil (NSO), and its chemical constituents against COVID-19.