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Until today, absolute treatment of this disease has not been found, however, there are treatments that
help in managing the symptoms. Treatment of this disease also depends on the nature of the
symptoms. It is, therefore, necessary for families and care takers of Huntington’s disease patients to
give them 24-care, close supervision and assistance. Tuvalu Uganda Ukraine United Arab Emirates
United States US Minor Outlying Is. It gives a complete medical dictionary covering hundreds of
terms and expressions relating to Huntington disease. Parkinsons disease is the most common of
several akinetic-rigid syndromes and Huntingtons disease is only one of an ever growing number of
trinucleotide repeat disorders. Autosomal dominant Death of nerve cells in brain Signs show around
middle age Due to defective (misshaped) gene. We don't know when or if this item will be back in
stock. For more information, please refer to our Privacy Policy. See Full PDF Download PDF See
Full PDF Download PDF Related Papers HUNTINGTON'S DISEASE: GENETICS,
PATHOGENIC MECHANISMS, ANIMAL MODELS AND THERAPEUTICS Ankur Gupta
Download Free PDF View PDF Molecular Basis of Huntington’s Disease and Brain Imaging
Evidence Antonia Plerou Huntington’s disease as a neurodegenerative disease is characterized by
motor and cognitive impairment. Prevalence in the Caucasian population is estimated at 110000-
120000. New clinical studies on managing and treating this disease will be of significant help to
future patients. People with Huntington disease have a faulty copy of the Huntington gene (HTT ).
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds
to upgrade your browser. This means that parents, who usually have less number of repeats, show
mild symptoms, which may later become more severe in their later lives. Let us write or edit the
research paper on your topic. Western Sahara Yemen Zambia Zimbabwe State or Province Please
Select. Nat Goodman Institute for Systems Biology January 2003. Using your mobile phone camera
- scan the code below and download the Kindle app. HuntingtonOs Disease (HD) is a late-onset and
progressive neurodegenerative disease of the central nervous system with autosomal dominant
inheritance. To review the existing literature on the prevalence of Huntingtons disease HD in the US
and Canada and to estimate the number of people in the US currently affected by this disease.
Symptomatic therapies, in particular dopamine blockers and neuroleptics, are presently the only
treatment for HD. Clinical researches such as the use of stem cells- specialized group of cells which
are capable of producing other cells- will help in developing new brain cells, which can be
transplanted into the patient’s brain so as to enhance their balance, thinking, swallowing and other
outlooks (HDSA, 2008). This is 100% legal. You may not submit downloaded papers as your own,
that is cheating. Also you. Currently, over 15,000 Americans live with Huntington’s disease, and at
least 150,000 others are at 50 percent risk of developing this disease. This disease causes part of
DNA, known as a CAG repeat, to replicate itself more than it is supposed to (Lawrence, 2009). It
gives a complete medical dictionary covering hundreds of terms and expressions relating to
Huntington disease. The Journal of Huntingtons Disease is a peer-reviewed medical journal that will
be launched in 2012 and will cover research on Huntingtons disease and related disorders. The
mutation underlying disease is the expansion of the highly polymorphic CAG repeat tract in the first
exon of the HD gene In fact, HD belongs to a group of disorders for which the causative mutation is
the expansion of CAG repeats in the respective genes. Abundant guidance is given on how to obtain
free-of-charge primary research results via the Internet. Genes are made up of deoxyribonucleic acid
(DNA): which is a molecule that exists as spiral ladder (HDSA, 2008). The severity of the disease
also depends on the number of CAG repeats in a DNA.
Pdf Huntington S Disease A Clinical Review Huntington disease peer reviewed article. In addition
to offering a structured and comprehensive bibliography, this medical reference on Huntington
disease will quickly direct you to resources and reliable information on the Internet, from the
essentials to the most advanced areas of research. As a result, individuals with this disease develop
complications associated with poor coordination, thought and cognitive abilities. Report this
Document Download now Save Save huntingtons disease For Later 0 ratings 0% found this
document useful (0 votes) 73 views 9 pages Huntingtons Disease Uploaded by api-320253549 AI-
enhanced title and description Huntington's disease affects the part of the brain that controls
thinking, emotion and movement which would be considered the basal ganglia. Bridge Clinic offers
both PGT and preimplantation genetic screening (PGS); please. The mutation underlying disease is
the expansion of the highly polymorphic CAG repeat tract in the first exon of the HD gene In fact,
HD belongs to a group of disorders for which the causative mutation is the expansion of CAG
repeats in the respective genes. The Journal of Huntingtons Disease is a peer-reviewed medical
journal that will be launched in 2012 and will cover research on Huntingtons disease and related
disorders. Second, the book also saves you time indexing and defining entries. Molecular genetic
studies and subsequent molecular biological studies have provided fascinating new insights into the
pathogenesis of both. Patients have mood swings, stubborn, anti-social, and more irritable (Lemiere,
2004). Dementia can result owing to many underlying pathologies which include Alzheimer's
disease, Huntington's disease and Creutzfeldt-Jacob disease. Until now actual remedy for the HD is
not available. Replacement of the defective Huntington’s disease gene with the normal genes in the
embryo can reduce the spread of this disease into future generations. Download Free PDF View PDF
See Full PDF Download PDF Loading Preview Sorry, preview is currently unavailable. For more
information check out our Privacy Policy. Hydrocephalus. Pronounced (high-droh- SEFF -ah-lus)
Defined. It is now taken as the probable way of the management of HD. HD is a dominant disorder
that is caused by a copy of a defective gene, which is inherited from one parent (HDSA, 2008). To
review the existing literature on the prevalence of Huntingtons disease HD in the US and Canada
and to estimate the number of people in the US currently affected by this disease. Myers 2004
NeuroRx. 1:255-62. Paulson Fischbeck Annu. Rev. Neurosci. 1996 19:79-107. Mutant mice. This
leads to functional inabilities and psychiatric. In normal conditions, this part of DNA section is
repeated 10 to 28 times. Until today, absolute treatment of this disease has not been found, however,
there are treatments that help in managing the symptoms. Treatment of this disease also depends on
the nature of the symptoms. It is, therefore, necessary for families and care takers of Huntington’s
disease patients to give them 24-care, close supervision and assistance. Find this author on Google
Scholar Find this author on PubMed Search for this author on this site. This is a treatment where the
parent’s embryos are tested for Huntington’s disease gene, and the genes that do not carry the
defective genes are replaced in the mother’s womb (Lemiere, 2004). You may unsubscribe from
these communications at any time. To calculate the overall star rating and percentage breakdown by
star, we don’t use a simple average. Symptomatic therapies, in particular dopamine blockers and
neuroleptics, are presently the only treatment for HD. Parkinsons disease is the most common of
several akinetic-rigid syndromes and Huntingtons disease is only one of an ever growing number of
trinucleotide repeat disorders. Thought you might appreciate this item(s) I saw in Current Opinion in
Neurology.
It is now taken as the probable way of the management of HD. Early symptoms include irritability,
depression, clumsiness, mild tremor, mood changes, lack of concentration, and short-term memory
problems (Lawrence, 2009). These researches, medicine, and therapy will lead to an effective
treatment of Huntington’s disease in the future. Molecular genetic studies and subsequent molecular
biological studies have provided fascinating new insights into the pathogenesis of both. Other
symptoms include hallucinations, paranoia, restlessness, psychosis, loss of judgment, speech changes,
loss of memory, confusion, personality, and behavioral disturbances. In addition, personality of the
patients becomes more centered and unmotivated (WebMD, 2011). Generally the time between the
first manifestation of symptoms and death is about 20 years. It is an inherit disease Brain disorder
that causes physical and emotional behavior, also mental. Therefore, they need 24-hour care, close
supervision and assistance (HDSA, 2008). It is mainly labeled to be a disease of the old people but it
may occur in the younger age groups as well. This condition affects basal ganglia that control balance
and movement in human beings (WebMD, 2011). This condition is known as chorea, and it leads to
the difficulty in swallowing, speaking and walking. Autosomal dominant Death of nerve cells in
brain Signs show around middle age Due to defective (misshaped) gene. The Journal of Huntingtons
Disease is a peer-reviewed medical journal that will be launched in 2012 and will cover research on
Huntingtons disease and related disorders. Hydrocephalus. Pronounced (high-droh- SEFF -ah-lus)
Defined. In the region of basal ganglia, HD mainly targets neurons of the striatum, especially those in
the pallidum and caudate nuclei. Recent advances in the signal analysis have engendered EEG with
the status of a true brain mapping and brain imaging method able of providing spatio-temporal
information regarding brain (dys)function. Thus each child of the affected person usually has 50%
chances of inheriting the Huntington's disease. Dementia can result owing to many underlying
pathologies which include Alzheimer's disease, Huntington's disease and Creutzfeldt-Jacob disease.
The mutation underlying disease is the expansion of the highly polymorphic CAG repeat tract in the
first exon of the HD gene In fact, HD belongs to a group of disorders for which the causative
mutation is the expansion of CAG repeats in the respective genes. If it is found out that a genetic
disease is produced from a specific allele or mutation being present, screening can be done to
identify who the individuals are. Find this author on Google Scholar Find this author on PubMed
Search for this author on this site. Thought you might appreciate this item(s) I saw in Current
Opinion in Neurology. Keep on browsing if you are OK with that, or find out how to manage
cookies. Parkinsons disease and Huntingtons disease are both model diseases. Emotional Symptoms
Emotional symptoms are as a result of damaged brain cells. Ut enim ad minim veniam, quis nostrud
exercitation ullamco. Report this Document Download now Save Save huntingtons disease For Later
0 ratings 0% found this document useful (0 votes) 73 views 9 pages Huntingtons Disease Uploaded
by api-320253549 AI-enhanced title and description Huntington's disease affects the part of the
brain that controls thinking, emotion and movement which would be considered the basal ganglia.
Currently, over 15,000 Americans live with Huntington’s disease, and at least 150,000 others are at
50 percent risk of developing this disease. Neurobiology of Disease. 1983 - Gusella, Wexler and
colleagues identify locus 1993 - Huntintin cloned, CAG, poly Q repeats identified.
Huntingtons disease is a devastating inherited neurodegenerative disease characterised by
progressive motor cognitive and psychiatric symptoms. Huntington disease HD is an adult-onset
autosomal dominant disorder characterized by progressive deterioration of intellectual function
bradykinesia rigidity and progressive chorea. History of HD. before the 19th century, people with
HD were thought to be possessed. Bases usually pair together, and combine with other pairs to form
coded messages. George Huntington first described the illness in 1872 in New York, but it wasn’t
until 1993 that researchers found the root cause of this disease. Abundant guidance is given on how
to obtain free-of-charge primary research results via the Internet. Nat Goodman Institute for Systems
Biology January 2003. Moreover, Huntington's disease appears more dominant with the course of
development, reflecting on the functional ability of the person infected. A normal gene is usually
composed of three DNA bases, made up of the sequence CAG. Therefore, children having a larger
number of repeats tend to develop symptoms of this disease at early ages. Authors aim to review
objectively and quantitatively the neurophysiological basis of the disease in HD patients as
compared to normal controls, with the use of brain imaging in general and EEG brain imaging
methods. Keep on browsing if you are OK with that, or find out how to manage cookies. It is a
family disease that is common in most countries, and the rate at which it is spreading is also
worrying, since there is no absolute treatment for this disease. The Journal of Huntingtons Disease is
a peer-reviewed medical journal that will be launched in 2012 and will cover research on
Huntingtons disease and related disorders. In HD patients, this sequence normally repeats itself
several times, and the number of repeats becomes larger in the subsequent generations. The primary
locus of the disorder is a polyglutamine expansion of the protein product of the huntingtin (htt) gene.
Revvity needs the contact information you provide us to keep you aware about relevant content,
products, and services. The effect of genes on determining an individual’s characteristics depends on
whether it is dominant or recessive. Find this author on Google Scholar Find this author on PubMed
Search for this author on this site. In the region of basal ganglia, HD mainly targets neurons of the
striatum, especially those in the pallidum and caudate nuclei. Prevalence in the Caucasian population
is estimated at 110000-120000. HD is a genetic neurodegenerative and ultimately fatal disease.
Using your mobile phone camera - scan the code below and download the Kindle app. Parkinsons
disease is the most common of several akinetic-rigid syndromes and Huntingtons disease is only one
of an ever growing number of trinucleotide repeat disorders. The Journal of Huntingtons Disease is a
peer-reviewed medical journal that will be launched in 2012 and will cover research on Huntingtons
disease and related disorders. Honduras Hong Kong (China) Hungary Iceland India Indonesia Iran
Iraq Ireland Israel Italy Jamaica Japan Jordan Kazakhstan Kenya Kiribati Korea (North) Korea
(South) Kuwait Kyrgyzstan Laos Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania
Luxembourg Macau Macedonia Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands
Martinique Mauritania Mauritius Mayotte Mexico Micronesia Moldova Monaco Mongolia
Montserrat Morocco Mozambique Myanmar N. Furthermore, the mutant HTT gene is occupied in the
HD associated changes of neurotransmission for enabling the neurodegeneration. As a result, you
may experience uncontrolled movements, emotional disturbances and mental deterioration. New
clinical studies on managing and treating this disease will be of significant help to future patients.
Therefore, they need 24-hour care, close supervision and assistance (HDSA, 2008).
Until today, scientists and researchers have very little understanding about this disease. This disease
causes progressive damage to brain cells in the cerebral cortex and basal ganglia (WebMD, 2011). The
only solution available is to slow down the symptoms from getting worse, and help patients to
function normally (HDSA, 2008). Myers 2004 NeuroRx. 1:255-62. Paulson Fischbeck Annu. Rev.
Neurosci. 1996 19:79-107. Mutant mice. Scientists and medical researchers should also double their
efforts to develop and improve drugs that will retard the development of this disease in both children
and adults. Parkinsons disease is the most common of several akinetic-rigid syndromes and
Huntingtons disease is only one of an ever growing number of trinucleotide repeat disorders.
Although it is well established that psychiatric symptoms are common in Huntingtons disease 1-5
research and clinical emphases have been on motor and cognitive aspects of the disorder. For readers
without access to Internet resources, a directory of medical libraries, that have or can locate
references cited here, is given. Ut enim ad minim veniam, quis nostrud exercitation ullamco.
Huntingtons disease HD is a rare neurodegenerative disease of the central nervous system
characterized by choreatic movements behavioral disturbances and neuropsychiatric sequelae. The
disease is inherited in an autosomal dominant fashion by an increased number of CAG repeats on the
short arm of chromosome 4p163 in the Huntingtin gene. As a result, you may experience
uncontrolled movements, emotional disturbances and mental deterioration. Download Free PDF
View PDF See Full PDF Download PDF Loading Preview Sorry, preview is currently unavailable.
Patients have mood swings, stubborn, anti-social, and more irritable (Lemiere, 2004). You can
download the paper by clicking the button above. In recent years it has become clear that HD can be
regarded as a systemic disorder affecting many organs and tissues causing peripheral as well as brain
pathology 2. Huntington’s can cause uncontrolled movement, loss of brain function, and a flux of
emotions. Authors aim to review objectively and quantitatively the neurophysiological basis of the
disease in HD patients as compared to normal controls, with the use of brain imaging in general and
EEG brain imaging methods. Since this is a hereditary disease, the number of repeats tends to get
bigger down the subsequent generations. Symptoms of Huntington’s disease HD symptoms are
usually mild and assumed for a long time before it fully develops. Huntingtons disease HD is a rare
autosomal dominant neurodegenerative disorder resulting from expansion of a CAG repeat within
the IT15 huntingtin htt gene on chromosome 4p. Until now actual remedy for the HD is not
available. The disease can result in incapacitation of the patient and eventual death. This condition
affects basal ganglia that control balance and movement in human beings (WebMD, 2011). For
readers unfamiliar with the Internet, detailed instructions are offered on how to access electronic
resources. Finally, it provides information to users on how to update their knowledge using various
Internet resources. Other symptoms include hallucinations, paranoia, restlessness, psychosis, loss of
judgment, speech changes, loss of memory, confusion, personality, and behavioral disturbances. The
heredity probability from a parent who has the condition is 50%, when both parents have the
condition; the children will have the disease and will pass it to their children (Folstein, 1989). New
clinical studies on managing and treating this disease will be of significant help to future patients.
Currently, over 15,000 Americans live with Huntington’s disease, and at least 150,000 others are at
50 percent risk of developing this disease.
The clinical symptoms of HD involve motor dysfunction, behavioural disturbances and cognitive
decline. For more information check out our Privacy Policy. Brunei Darussalam Bulgaria Burkina
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Dem. Difficulties can also reflect in the physical production of speech and the process of
swallowing, an observation key in aggravated cases of Huntington's disease. In addition, personality
of the patients becomes more centered and unmotivated (WebMD, 2011). However, in HD patients,
it is repeated 36 to 120 times. The Journal of Huntingtons Disease is a peer-reviewed medical journal
that will be launched in 2012 and will cover research on Huntingtons disease and related disorders.
History of HD. before the 19th century, people with HD were thought to be possessed. This is a
treatment where the parent’s embryos are tested for Huntington’s disease gene, and the genes that do
not carry the defective genes are replaced in the mother’s womb (Lemiere, 2004). These bases
include adenine (A), thymine (T), cytosine (C) and guanine (G). What prompted him to write “Clash
of Civilizations” What has he done since. Dementia can result owing to many underlying pathologies
which include Alzheimer's disease, Huntington's disease and Creutzfeldt-Jacob disease. This disease
can develop at any age, however, it is most common between the ages of 30 to 50. The human HD
gene (IT-15) was localized to chromosome 4p16.3 and consists of 67 exons spanning 180 kb of
DNA. A normal gene is usually composed of three DNA bases, made up of the sequence CAG. The
pathology of HD is restricted to the brain, and the predominant neuropathological hallmark is
selective loss of neurons within the striatum. Huntington disease causes the degeneration of nerve
cells in brain. Instead, our system considers things like how recent a review is and if the reviewer
bought the item on Amazon. References Folstein S. E. (2004). Huntington's disease: a disorder of
families. Most of the current therapeutics for HD thus have been targeted at preventing neuronal
damage in the CNS, however, a considerable body of evidence has been accumulating to suggest that
the maintenance of a healthy nervous system is tightly linked with periph. Parkinsons disease and
Huntingtons disease are both model diseases. The first page of the PDF of this article appears above.
Crossref (13) Google Scholar This article has been cited by the following articles in journals that are
participating in Crossref Cited-by Linking. Finally, you will not waste time and money printing
hundreds of web pages. Read more. In this review we describe the symptomatic and neuroprotective
therapies in HD that are currently in a pre-clinical or clinical stage. Some of the drugs that have been
developed include nutritional supplement, co-enzyme Q10, and minocycline, which is an antibiotic
drug. HD is an autosomal dominant neurodegenerative disorder characterized by cognitive deficits
psychosis and motor dysfunction Finkbeiner 2011. This disease causes part of DNA, known as a
CAG repeat, to replicate itself more than it is supposed to (Lawrence, 2009). Western Sahara Yemen
Zambia Zimbabwe State or Province Please Select. Typically presents with alterations in mood as
well as a change in character, defects in memory and attention.