GNIPST BULLETIN 2013

1118-1177-4796-9849-7562-5062

TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCE

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13th December , 2013

Volume No.: 31

Issue No.: 01

Vision

Contents
Message from GNIPST Letter to the Editor News Update Health awareness Disease Outbreak News Forth Coming Events Drugs Update GNIPST Photo Gallery
For your comments/contributionOR

Campus News Students Section Editors Note Archive

For Back-Issues,
mailto:gnipstbulletin@gmail.com

1 EDITOR: Soumya Bhattacharya

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

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MESSAGE FROM GNIPST

GNIPST BULLETIN is the official publication of Guru Nanak Institute of Pharmaceutical Science & Technology. All the members of GNIPST are proud to publish the 31st Volume of GNIPST BULLETIN. Over the last two years this bulletin updating readers with different scientific, cultural or sports activities of this prestigious institute and promoting knowledge of recent development in Pharmaceutical and Biological Sciences. Students section is informing readers about some curious facts of drug discovery, science, sports and other relevant fields. We look forward to seeing your submission and welcome comments and ideas you may have.

LETTER TO THE EDITOR.

NEWS UPDATE

Dietary Amino Acids Improve Sleep Problems in Mice with Traumatic Brain Injury (11th December, 2013)
Scientists have discovered how to fix sleep disturbances in mice with traumatic brain injuries, a discovery that could lead to help for hundreds of thousands of people who have long-term and debilitating sleep and wakefulness issues after they suffer concussions. Read more

Stimulant-Addicted Patients Can Quit Smoking without Hindering Treatment (11th December, 2013)

Smokers who are addicted to cocaine or methamphetamine can quit smoking while being treated for their stimulant addiction, without interfering with stimulant addiction treatment. This is according to new research funded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health. Read more
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More Powerful Approach to Analyze Melanoma's Genetic Causes (11th December, 2013)
There may be a better way to analyze the genetic causes of cutaneous melanoma (CM) according to a study published in Human Genetics conducted by researchers Yale and Dartmouth. A statistical analysis using the natural and orthogonal interaction (NOIA) model showed increased power over existing approaches for detecting genetic effects and interactions when Read more

Antiviral for HCV Improve Kidney, Cardiovascular Diseases in Diabetic Patients (11th December, 2013)
Researchers from Taiwan reveal that antiviral therapy for hepatitis C virus (HCV) improves kidney and cardiovascular outcomes for patients with diabetes. Results of the study published in Hepatology, a journal of the American Association for the Study of Liver Diseases, show that incidents of kidney disease, stroke, and heart attack were lower in patients treated with pegylated interferon and ribavirin compared to HCV patients not treated with antivirals or diabetic patients not infected with the virus. Read more

Researchers Find Shape-Shifting Stops Migrating Cancer Cells (4th December, 2013)
In research published in the December issue of Molecular and Cellular Biology, investigators reveal how interplay of molecules keeps cancer cells moving forward, and how disturbing the balance of these proteins pushes their shape to change, stopping them in their tracks. Investigators say they have already identified a number of agents some already used in the clinic for different disorders that may force shapeshifting in tumor cells. Read more

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Newly

Identified

Brown

Fat

Stem

Cells

Hold
(21st

Possibilities for Treating Diabetes, Obesity

November, 2013)

Obesity and diabetes have become a global epidemic leading to severe cardiovascular disease. Researchers at the University of Utah believe their recent identification of brown fat stem cells in adult humans may lead to new treatments for heart and endocrine disorders, according to a new study published in the peer-reviewed journal Stem Cells. Read more

HEALTH AWARENESS

Dementia
Dementia is a syndrome usually of a chronic or progressive nature in which there is deterioration in cognitive function (i.e. the ability to process thought) beyond what might be expected from normal ageing. It affects memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement. Consciousness is not affected. The impairment in cognitive function is commonly accompanied, and occasionally preceded, by deterioration in emotional control, social behaviour, or motivation. Dementia is caused by a variety of diseases and injuries that primarily or secondarily affect the brain, such as Alzheimer's disease or stroke. Dementia is one of the major causes of disability and dependency among older people worldwide. It is overwhelming not only for the people who have it, but also for their caregivers and families. There is often a lack of awareness and understanding of dementia, resulting in stigmatization and barriers to diagnosis and care. The impact of
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dementia on caregivers, family and societies can be physical, psychological, social and economic. Signs and symptoms Dementia affects each person in a different way, depending upon the impact of the disease and the persons personality before becoming ill. The signs and symptoms linked to dementia can be understood in three stages. Early stage: the early stage of dementia is often overlooked, because the onset is gradual. Common symptoms include:

forgetfulness losing track of the time becoming lost in familiar places. Middle stage: as dementia progresses to the middle stage, the signs and symptoms become clearer and more restricting. These include:

becoming forgetful of recent events and people's names becoming lost at home having increasing difficulty with communication needing help with personal care experiencing behaviour changes, including wandering and repeated questioning. Late stage: the late stage of dementia is one of near total dependence and inactivity. Memory disturbances are serious and the physical signs and symptoms become more obvious. Symptoms include:

becoming unaware of the time and place having difficulty recognizing relatives and friends having an increasing need for assisted self-care having difficulty walking experiencing behaviour changes that may escalate and include aggression.
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Common forms There are many different forms, or causes, of dementia. Alzheimer's disease is the most common form of dementia and may contribute to 6070% of cases. Other major forms include vascular dementia, dementia with Lewy bodies (abnormal aggregates of protein that develop inside nerve cells), and a group of diseases that contribute to frontotemporal dementia (degeneration of the frontal lobe of the brain). The boundaries between different forms of dementia are indistinct and mixed forms often co-exist. Rates of dementia Worldwide, 35.6 million people have dementia, with just over half (58%) living in low- and middle-income countries. Every year, there are 7.7 million new cases. The estimated proportion of the general population aged 60 and over with dementia at a given time is between 2 to 8 per 100 people. The total number of people with dementia is projected to almost double every 20 years, to 65.7 million in 2030 and 115.4 million in 2050. Much of this increase is attributable to the rising numbers of people with dementia living in low- and middle-income countries. Treatment and care There is no treatment currently available to cure dementia or to alter its progressive course. Numerous new treatments are being investigated in various stages of clinical trials. Much can be, however, offered to support and improve the lives of people with dementia and their caregivers and families. The principal goals for dementia care are:

early diagnosis optimizing physical health, cognition, activity and well-being

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identifying and treating accompanying physical illness detecting and treating behavioural and psychological symptoms providing information and long-term support to caregivers. Risk factors and prevention Research identifying modifiable risk factors of dementia is scarce. Prevention focuses on targets suggested by available evidence, which include countering risk factors for vascular disease, such as diabetes, midlife hypertension, midlife obesity, smoking and physical inactivity. Social and economic impacts Dementia has significant social and economic implications in terms of direct medical costs, direct social costs and the costs of informal care. In 2010, the total global societal costs of dementia was estimated to be US$ 604 billion. This corresponds to 1.0% of the worldwide gross domestic product (GDP), or 0.6% if only direct costs are considered. The total cost as a proportion of GDP varied from 0.24% in lowincome countries to 1.24% in high-income countries. Impact on families and caregivers Dementia is overwhelming for the families of affected people and for their caregivers. Physical, emotional and economic pressures can cause great stress to families and caregivers, and support is required from the health, social, financial and legal systems. Dementia is one of the priority conditions in the WHO Mental Health Gap Action Programme (mhGAP), which aims to scale up care for mental, neurological and substance use disorders. (Based on WHO database)

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DISEASE OUTBREAK NEWS

Chikungunya in the French part of the Caribbean isle of Saint Martin (11th December,2013)
WHO was notified of two laboratory confirmed cases of locally acquired chikungunya disease in the French part of the Caribbean isle of Saint Martin. The other part of the isle is a country that is part of the Kingdom of the Netherlands (Sint Maarten). These two cases were confirmed by polymerase chain reaction (PCR) test performed by the French National Reference Centre for arboviruses in Marseille.
Read more

FORTHCOMING EVENTS

The 2nd Pharm. Tech IAPST International Conference on "New insights into
diseases and recent therapeutic approaches" from 17th to 19th January 2014 in Kolkata, India. Read more

DRUGS UPDATES

FDA

approves

first

generic

versions

of

antidepressant drug Cymbalta

(11th December, 2013)

The U.S. Food and Drug Administration today approved the first generic versions of Cymbalta (duloxetine delayed-release capsules), a
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prescription medicine used to treat depression and other conditions. Aurobindo Pharma Ltd., Dr. Reddys Laboratories Ltd., Lupin Ltd., Sun Pharma Global FZE, Teva Pharmaceuticals USA, and Torrent Pharmaceuticals Ltd. have received FDA approval to market duloxetine in various strengths.
Read more

CAMPUS NEWS B.Pharm 3rd year won the GNIPST Football Champions trophy,
2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd year. Deep Chakraborty was the only scorer of the final.

Students of GNIPST organized pre puja celebration programme,

Saaranya on 7th October, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28th

September, 2013 at Dakshineswar Kali Temple and Adyapith, Kolkata. On this remarkable event about hundred people have received garments. More than hundred students and most of the faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29th September) and

Pharmacists Day(25th September) on 25th and 26th September, 2013 in GNIPST Auditorium. A seminar on Violence against woman and female foeticide was held on GNIPST Auditorium on 25th September organized by JABALA Action Research Organization. On 26th September an intra-college Oral and Poster presentation competition related to World Pharmacists day and Heart day was held in GNIPST. Ms. Purbali Chakraborty of
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B.Pharm 4th year won the first prize in Oral Presentation. The winner of Poster presentation was the group of Ms. Utsa Sinha, Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year). A good number of students have participated in both the competition with their valuable views.

STUDENTS SECTION
WHO CAN ANS WER FIRS T???? Karplus, Levitt and Warshell won Nobel prize in

which discipline?
Franois Englert and Peter Higgs were awarded the

2013 Nobel Prize in Physics for the theory of how particles acquire mass. In 1964, they proposed their ideas independently of one another. When were their ideas confirmed?

Answer of Previous Issues Questions:

A) Harald zur Hausen for his discovery of "human papilloma viruses causing cervical cancer"and the other half jointly toFranoise BarrSinoussi and Luc Montagnier for their discovery of "human immunodeficiency virus" B) Ritonavir

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Identify the place

Answer of Previous Issues Image:

Arthur Robert Ashe,( July 10, 1943 February 6, 1993) was an American World No. 1 professional tennis player. In the early 1980s, Ashe contracted HIV from a blood transfusion he received during heart bypass surgery. He founded the Arthur Ashe Foundation for the Defeat of AIDS and the Arthur Ashe Institute for Urban Health before his death from AIDS-related pneumonia on February 6, 1993.

Solve the Puzzle

3/8 *4/7*? =5376 Answer of Previous Issues Puzzle:
2

Send your thoughts/ Quiz/Puzzles/games/writeups or any other contributions for Students Section& answers of this Section atgnipstbulletin@gmail.com
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EDITORS NOTE I am proud to publish the 1st issue of 31st Volume of GNIPST BULLETIN. GNIPST BULLETIN now connected globally through facebook account GNIPST bulletin I want to convey my thanks to all the GNIPST members and the readers for their valuable comments, encouragement and supports. I am thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha and Mr. Debabrata Ghosh Dastidar for their kind co-operation and technical supports. I am thankful to Mr. Subha Bhattacharjee for his contribution to solve the puzzle section .An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

ARCHIVE

Teachers day was celebrated on 5th September, 2013 by the students of GNIPST in GNIPST Auditorium. Azalea (exotic flower ) , the fresher welcome programme for
newcomers of GNIPST in the session 2013-14 was held on 8th August in GNIPST Auditorium. One day seminar cum teachers development programme for school teachers on the theme of Recent Trends of Life Sciences
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in Higher Education organized by GNIPST held on 29th June, 2013 at GNIPST auditorium. The programme was inaugurated by Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit Sengupta, Director cum Principal of GNIPST with lamp lighting. The programme started with an opening song performed by the B.Pharm students of this institute. The seminar consists of a series of lectures, video presentations and poster session. On the pre lunch session 4 lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty respectively. On their presentation the speakers enlighten the recent development of Pharmacy, Genetics and Microbiology and their correlation with Life Sciences. On the post lunch session, Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the recent development and career opportunities in Biotechnology and Hospital Management. The programme was concluded with valedictory session and certificate distribution. About 50 Higher secondary school teachers from different schools of Kolkata and North& South 24 Parganas district of West Bengal participated in this programme. A good interactive session between participants and speakers was observed in the seminar. The seminar was a great success with the effort of faculties, staffs and students of our Institute. It was a unique discussion platform for school teachers and professional of the emerging and newer branches of Life Science. The following B.Pharm. final year students have qualified, GPAT2013. We congratulate them all.

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The general body meeting of APTI, Bengal Branch has been conducted at GNIPST on 15th June, 2012. The program started with a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day. GNIPST is now approved by AICTE and affiliated to WBUT for conducting the two years post graduate course (M.Pharm) in PHARMACOLOGY. The approved number of seat is 18. The number of seats in B.Pharm. has been increased from 60 to 120. AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below:
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a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. LopamudraDutta. c. Grant-in-aid sanctioned:Rs. 16,25000/- only d. Approved duration: 3 years e. Title of the project: Screening and identification of potential medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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