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The effect of Vernonia amygdalina extract (VA) on kidney and liver function indices in BPH was
investigated. To browse Academia.edu and the wider internet faster and more securely, please take a
few seconds to upgrade your browser. Grey areas where research is required to promote effective use
of this plant product are indicated. You can download the paper by clicking the button above. The
plant has antibacterial, hepatoprotective, hypolipidemic, hypoglycemic, and antioxidant
pharmacological effects. There is a need to establish these claims in humans. By Philip Boobbyer.
Athens: Ohio University Press, 1995. IJAR Indexing Conflicting scientific reports have trailed the
hepatotoxicity of the roots of Vernonia amygdalina in animal studies. Some of the bitter leaves were
collected from various gardens as bitter leaf widely grows in most parts of Nigeria. However, its
effects on oxidative stress imposed by opiods has yet to be determined.This research therefore aims
to investigate the attenuating potentials of Vernonia Amygdalina ethanol leafextract on oxidative
stress biomarkers, following the administration of graded doses of tramadol. Very important literature
before that was not recent was also included. More animal models experiments are required to prove
the potency of this plant product. Sources of information for this review were obtained from online
search engines. There are a lot of claims on this plant-based on ethnomedicine and traditional uses.
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds
to upgrade your browser. Blood was collected by cardiac puncture and the sera centrifuged and used
for the determination of lipid profile. Methods: BPH was induced in 45 male Wistar rats (250-350 g)
by exogenous injection of testosterone and estradiol in staggered doses for 3 weeks. Methods: BPH
was induced in male rats weighing 250-350 g. At the same time, treatment finasteride and CESH to
the respective groups were given orally 60 minutes after the BPH induction for 28 uninterrupted
days. Results: Results showed that induction of BPH caused a significant (P Download Free PDF
View PDF International Conference on Scientific and Innovative Studies Vernonia Amygdalina
Ethanol Leaf Extract Protects Against Tramadol-Induced Organ Damages Through Inhibition of
Oxidative Stress Nwabuoku, Udoka Shalom Vernonia amygdalinaas has been found to lower blood
pressure, reduces body weight, andimprove fertility. One group was used as a control and the other
groups received subcutaneous injections of testosterone and estradiol for 3 weeks to induce BPH.
The harvested prostate were processed for paraffin embedding and stained with H and E. To browse
Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade
your browser. As BPH and aberrant changes in reactive oxygen species become more common with
ageing, oxygen species signalling may play an important role in the development and progression of
this disease. Selection of literature and abstracts was done randomly by authors on the basis of their
relevance to the immediate review. The effect of Prosopis africana (PA), Vernonia amydalina (VA)
and Ocimum gratissmum (OG), plant extracts on haematological parameters of BPH animal model
was investigated. To confirm BPH induction, some animals Original Research Article Ugwu et al.;
IBRR, 10(1): 1-15, 2019; Article no.IBRR.53052 2 were sacrificed; histological inspection of
prostate gland and PSA was carried out. The searches were restricted to information available as
primary or secondary sources and effort was made to keep to only recent literature. Groups 1 and 2
were treated with different doses of VA extracts and group 3 received finasteride, while group 4 was
left untreated, group 5 served as normal control.
Results: The activities of catalase (CAT) and superoxide dismutase (SOD) in the extract treated rats
were significantly increased when compared the BPH control which had a significant reduction in
the activities of these enzymes. Groups I and II were treated with different doses of VA extract (50
and 100 mg kg-1 body weight respectively) and group III received finasteride (0.1 mg kg-1), all by
gavages for forty-two days, while group IV was left untreated, group V served as normal control.
While group IV was left untreated, group V served as normal control. Blood was collected by
cardiac puncture and the sera centrifuged and used for the determination of lipid profile. Search
yielded 512 results; critical appraisal of results reduced the tally to 6 for anticancer properties and 5
for hepatoprotective studies respectively. The extracts were administered orally to the animals for 14
days. After forty-five days of treatment with VA extract, the rats were sacrificed. Results: Results
showed that induction of BPH caused a significant (P Download Free PDF View PDF International
Conference on Scientific and Innovative Studies Vernonia Amygdalina Ethanol Leaf Extract
Protects Against Tramadol-Induced Organ Damages Through Inhibition of Oxidative Stress
Nwabuoku, Udoka Shalom Vernonia amygdalinaas has been found to lower blood pressure, reduces
body weight, andimprove fertility. In this study, we investigated the effect of Nigerian indigenous
plant; Vernonia amygdalina (VA) on oxidative stress indices in BPH induced rats. The study
investigated the toxic effect of the aqueous extract of the roots of V. Vernonia amygdalina Delile
(VAD) is a common edible vegetable in Cameroon that has been used as a traditional medicine for
some human diseases. The plant has antibacterial, hepatoprotective, hypolipidemic, hypoglycemic,
and antioxidant pharmacological effects. It contains many nutrients and phytochemicals such as
iodine, alkaloids, anthraquinones, edotides, sesquiterpene lactones and steroid glycosides. Materials
and Method: The literatures consulted were searched using electronic search engines (Google,
Google scholar and Pubmed). The induction of BPH with testosterone propionate injection caused a
significant reduction in the serum levels of haematological parameters, including haemoglobin (Hb),
packed cell volume (PCV), red blood cells (RBC), and platelet counts of the BPH control compared
with normal. You can download the paper by clicking the button above. The stromal and, to a lesser
degree, epithelial cells of the prostate become hyperplastic, causing the prostate to enlarge. The
animals wereacclimated for seven days, divided into six groups of five animals in each group.
Selection of literature and abstracts was done randomly by authors on the basis of their relevance to
the immediate review. Some of the bitter leaves were collected from various gardens as bitter leaf
widely grows in most parts of Nigeria. We investigated the effect of aqueous extract of Vernonia
amygdalina (VA) on BPH. The effect of Vernonia amygdalina extract (VA) on kidney and liver
function indices in BPH was investigated. Vernoniaamydgalina is rich in nutrients and
phytochemicals and this invariable account for its positive influence on health. The harvested
prostate were processed for paraffin embedding and stained with H and E. The objective of the
present study was to assess the anticancer activities of VAD methanolic extracts in the prevention
and treatment of prostate cancer using human androgen-independent prostate cancer (PC-3) cells as
a test model. By Philip Boobbyer. Athens: Ohio University Press, 1995. Substantial amount of
literature was consulted but only those directly related to the main review were selected.Result: The
review revealed that the three bitter vegetables possessed phytochemicals like saponins, flavonoids,
alkaloids among others that justify the claims of curing and managing many of the illnesses that
traditional folks attribute to them. This study was designed to study the ameliorative effect of the
aqueous extract of bitter leaf Vernonia amygdalina Delile (Asterales: Asteraceae) on testosterone-
induced BPH in a rat model. From literature, antimicrobial, antinflammatory, antidiabetic, an.
Diseases associated with liver include: fibrosis, cirrhosis, liver failure and Download Free PDF View
PDF Effect of Vernonia amygdalina Ethanolic Root Extract on the Hepato- and Nephro-Protective
Properties of Albino Rats (Rattus novergicus) emmanuel nnamonu, Emmanuel Nnamonu, Paul C
Echi The hepato- and nephro-protective potentials of Vernonia amygdalina ethanolic root extract was
evaluated for 14 days using standard bioassay in 45 normal male albino rats.
Original Research Article Nnaemeka et al.; JOCAMR, 6(1): 1-12, 2018; Article no.JOCAMR.42506
2 Groups 1 and 2 were treated with different doses of VA extracts and group 3 received finasteride,
all by gavages for forty-five days, while group 4 was left untreated, group 5 served as normal
control. The objective of the present study was to assess the anticancer activities of VAD methanolic
extracts in the prevention and treatment of prostate cancer using human androgen-independent
prostate cancer (PC-3) cells as a test model. Sources of information for this review were obtained
from online search engines. Compounds associated with its anticancer effects, antioxidant properties,
antimalarial properties, anti-inflammatory properties, antimicrobial properties and hypolipidaemic
effects have been identified but most mechanisms of action have not been elucidated in humans.
After forty-five days of treatment with VA extract, the rats were sacrificed. For Later 0 ratings 0%
found this document useful (0 votes) 25 views 17 pages Analysis of the Antimicrobial and
Antioxidant Properties of Various Extracts of Vernonia amygdalina Leaves Uploaded by Chha-fiidh
AI-enhanced title Antimikroba Full description Save Save antimicrobial-and-antioxidant-studies-of-
vernonia-. This was administered to the rats for three weeks subcutaneously in the inguinal region.
Therefore, it is important to seek a new alternative therapeutic medicine that can effectively prevent
the disease and even eradicate the progression and metastasis of prostate cancer. By Philip Boobbyer.
Athens: Ohio University Press, 1995. For Later 0% 0% found this document useful, Mark this
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Embed Share Jump to Page You are on page 1 of 17 Search inside document. Vernonia amygdalina
Delile (VAD) is a common edible vegetable in Cameroon that has been used as a traditional medicine
for some human diseases. The present study investigated the protective role of methanolic leaf extract
of Vernonia amygdalina (MLVA) against Nitrobenzene-induced oxidative testicular damage and
hormonal imbalance in rats. Results: Results showed that induction of BPH caused a significant (P
Download Free PDF View PDF International Conference on Scientific and Innovative Studies
Vernonia Amygdalina Ethanol Leaf Extract Protects Against Tramadol-Induced Organ Damages
Through Inhibition of Oxidative Stress Nwabuoku, Udoka Shalom Vernonia amygdalinaas has been
found to lower blood pressure, reduces body weight, andimprove fertility. Groups I and II were
treated with different doses of VA extracts and group III received finasteride, all by gavages for
thirty-five days. Their therapeutic potencies had relevance with phytochemical content of V.
amygdalina. The experimental results support the widely accepted hepatoprotective and anticancer
properties of V. Herbal medicine is the oldest form of healthcare known to mankind and over 50% of
all modern clinical drugs are of natural products origin and natural products play important roles in
drug development in the pharmaceutical industry. To browse Academia.edu and the wider internet
faster and more securely, please take a few seconds to upgrade your browser. Thirty sexually active
male wistar rats were sorted into five groups, each group containing six rats. More animal models
experiments are required to prove the potency of this plant product. Traditional users report that this
plant possesses observable health benefits. This review is a comprehensive update on the composition
of V. All analyses were completed within 24 h of sample collection. The searches were restricted to
information available as primary or secondary sources and effort was made to keep to only recent
literature. The harvested prostate were processed for paraffin embedding and stained with H and E.
Blood was collected by cardiac puncture and the sera centrifuged and used for the determination of
different biochemical indices. Report this Document Save Save antimicrobial-and-antioxidant-
studies-of-vernonia-. Blood was collected by cardiac puncture and the sera centrifuged and used for
the determination of lipid profile. Diseases associated with liver include: fibrosis, cirrhosis, liver
failure and Download Free PDF View PDF Effect of Vernonia amygdalina Ethanolic Root Extract
on the Hepato- and Nephro-Protective Properties of Albino Rats (Rattus novergicus) emmanuel
nnamonu, Emmanuel Nnamonu, Paul C Echi The hepato- and nephro-protective potentials of
Vernonia amygdalina ethanolic root extract was evaluated for 14 days using standard bioassay in 45
normal male albino rats. After thirty-five days of treatment with VA extract, the rats were
anaesthetised by short contact with trichloromethane vapour. We investigated the effect of aqueous
extract of Vernonia amygdalina (VA) on BPH.