Calcifying Epithelial Odontogenic Tumor

Odontogenic Tumors

Synopsis
1. Other Names
2. Classification
3. Introduction
4. Clinical Features
5. Radiographic Features
6. Histological Features
7. Treatment and Prognosis

Name Dr Soumya A
Sri Ramachandra Dental College
Calcifying Epithelial Odontogenic Tumor
Other Names

Pindborg Tumor
1956
Dr Jens J Pindborg

Name Dr Soumya A
Sri Ramachandra Dental College
Calcifying Epithelial Odontogenic Tumor
Introduction

Remnants of primitive dental lamina

Epithelial rests
Reduced enamel epithelium
Mutation of PTCH 1 gene
Mutations in sonic hedgehog signalling pathway

Name Dr Soumya A
Sri Ramachandra Dental College
Calcifying Epithelial Odontogenic Tumor
Clinical Features

Age- Middle age

Gender- No predilection
Site- 2:1 (Maxilla: Mandible)
Asymptomatic
Painless swelling
Unerupted tooth- 52%
2 types: Intra and Extra osseous

Name Dr Soumya A
Sri Ramachandra Dental College
 Calcifying Epithelial Odontogenic Tumor
Radiographic Features

Diffuse, well circumscribed, unilocular radiolucency, radio-opacity with many small, irregular
trabeculae traversing the radiolucent areas . Scattered flecks of calcifications.

Name Dr Soumya A
Sri Ramachandra Dental College
 Calcifying Epithelial Odontogenic Tumor
Histopathology

• Polyhedral epithelial cells closely packed in large sheets

• Small islands of tumor cells in a bland fibrous connective tissue
stroma
• Arrangement- Cords or rows- mimicking adenocarcinoma
• Granular eosinophilic cytoplasm, pleomorphic nuclei,
• Nuclei- flat, oval in centre
• Clear cells- Negative for mucicarmine
• Liesegang Calcifications – homogenous, eosinophilic
• Made of: amyloid, glycoprotein, basal lamina, keratin, enamel matrix
• Stains: Congo red, Flourses with Thioflavin T , PAS- Negative to
Positive (Coalesced)

Name Dr Soumya A
Sri Ramachandra Dental College
Calcifying Epithelial Odontogenic Tumor
Clinical Features

Name Dr Soumya A
Sri Ramachandra Dental College
Calcifying Epithelial Odontogenic Tumor
Treatment and Prognosis

Enucleation and curettage – well defined lesions

Partial- hemi mandibulectomy / maxillectomy
Recurrence rate: 10-20%

Name Dr Soumya A
Sri Ramachandra Dental College