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Gui Zhi Tang (Cinnamon Twig Formula)
Gui Zhi Tang (Cinnamon Twig Formula)
Cinnamon Twig Formula (Gui Zhi Tang), is one of the most enduring and versatile formulas in the
history of Chinese herbal medicine. The first appearance of Cinnamon Twig Formula in text dates from the
Eastern Han Dynasty (25-220 A.D.). The source text is the Shang Han Lun, written by Zhang Zhong Jing.
General Signs/Symptoms
Cinnamon Twig Formula is the quintessential formula for harmonizing the wei (protective) qi and the ying
(nutritive) qi. Clinically, this includes various applications, such as skin allergies, the common cold and other
respiratory issues, inability to regulate body temperature, specific types of constipation, and the initial stages
of wind-cold-damp bi syndrome. It is the very first formula discussed in Zhang Zhong Jing’s book On Cold
Damage, which emphasizes its use as the primary formula to treat taiyang wind-strike pattern. The two
decisive diagnostic features of taiyang wind-strike pattern are spontaneous sweating with aversion to wind.
Other signs and symptoms may include low-grade fever and chills, headache, stiff neck, nasal congestion, dry
heaves, and no thirst.
Classical Applications
1. Taiyang wind-strike pattern or 2. Loss of regulation between 4. Mismanaged treatment of
invasion from wind-cold (with wei and ying after illness, taiyang stage illness
wind predominant) childbirth, or with weak • When sweating has been promoted to
• Spontaneous sweating constitution dispel cold, but has failed to eliminate
• Aversion to wind • Spontaneous sweating the pathogen
• Aversion to wind • When purgation has been used to treat
• Fever, unrelieved by sweating
a taiyang cold pattern, but exterior
• Chills • Fever
signs persist
• Headache
3. Intermittent release of heat • When mild exterior signs persist after
• Nasal congestion several days of illness and the pulse is
• Hot flashes
• Neck stiffness • Spontaneous sweating floating and weak or moderate
• Dry heaves
• Little or no thirst, or thirst for warm 5. Taiyang disease in which the
drinks patient is unable to defecate
for 4+ days, but urine is clear
and unobstructed
Ingredients
Pinyin Latin English Percent of Formula
Gui Zhi (Chief) Cinnamomi (ramulus) Cinnamon Twig 21.4%
Bai Shao (Deputy) Paeoniae (radix), alba Chinese White Peony 21.4%
Sheng Jiang (Assistant) Zingiberis (rhizoma) recens Fresh Ginger 21.4%
Da Zao (Assistant) Jujubae (fructus) Jujube Fruit, Chinese Red Date 21.4%
Zhi Gan Cao (Envoy) Glycyrrhizae (radix), preparata Chinese Licorice Root, honey-fried 14.4%
General Indications / Modern Applications
With the appropriate presentation, Cinnamon Twig Formula may be used to treat a number of patterns
involving the respiratory, integumentary, and cardiovascular systems. There are also modern studies supporting
the use of Cinnamon Twig Formula in treating psycho-emotional disorders.
• Allergic purpura • Constipation • Post-partum or post-illness
• Allergic rhinitis • Eczema colds, flu, or fever
• Angioedema • Enuresis • Psychological boundary issues
• Arthritis • Frostbite • Sciatica
• Bronchial asthma • Functional cardiac disorders • Testicular pain
• Cardiovascular disease • Hyperactivity disorder • Upper respiratory tract infection
• Cerebrovascular spasm • Influenza • Urticaria
• Common cold • Menopausal syndrome
Formula Actions
Synergy of Ingredients
2
yang. Its yin function is to moisten; its yang function between the ying and wei.
is to provide the medium for the wei qi to guide out
Many of the pathologies that result when ying and
waste material from the tissues. The ying qi provides
wei are disharmonious occur at the level of the in-
the jin fluid of the interstitial zones, but the move-
terstitial fluids. For instance, when wind penetrates
ment through the fluid is governed by the wei qi. On
into the interstices beneath the skin and blocks wei
the outside of the skin, sweat is ying, but its release,
qi from moving along the interstitial fluid, the ying
the act of sweating, is wei. The ying provides the
may try to remedy the situation by transforming
sweat from the blood, but the wei opens the pores to
more blood into jin, but if the jin meets the wind
release it to the exterior. Of course, sweat is not the
before it meets the wei qi, the combination can cause
only substance that is released through the pores of
the jin to degrade into dampness.
3
The formation of dampness in the interstices is an to fight off the pathogen, but the wind binds the wei
4
example of a ying and wei disharmony from the qi in the fleshy exterior and prevents it from regulat-
Cinnamon Twig Formula
penetration of external wind. Internal wind can ing the opening and closing of the pores.
also cause an acute disharmony in the interstitial
The interstitial fluid is the medium of convey-
zones. Hives is a good example of this. Hives is
ance for the wei qi in the flesh, just as blood is the
often described as “wind in the blood.” But where
medium of conveyance for the ying qi in the ves-
did this wind come from? Internal wind is qi that
sels. When the wei qi is circulating properly in the
has become “confused” about its function, location,
interstitial areas, the force from its movement and
direction, or rate of flow. It has broken down into
its expansive nature help to maintain a secure bar-
something else; it has become “unrighteous.” The
rier between the vessels and the fleshy areas outside
zheng qi, or “righteous” qi that remains then has the
the vessels. When exterior wind penetrates into
job of calling upon the wei qi to eliminate the newly
the flesh, it binds the wei qi, slowing its movement
formed wind. In hives, the wind is in the blood. The
and limiting its expansion. It is the nature of ying
ying can’t handle wind in the blood, it cannot trans-
to support wei by supplying fluid to the interstices,
form it into a different kind of fluid because wind is
but when the wei qi is bound in the flesh by exterior
yang. All the ying qi can do is force the pathogenic
wind, as when there is wind-strike, the fluid sup-
factor to the walls of the vessels or transform blood
plied by the ying is wasted: instead of providing a
into jin and dump it into the interstitial zone. The
medium for the wei qi, the fluid just leaks out the
need to expel the pathogenic factor from the ves-
pores. The movement of the wei qi is insufficient to
sels invites wei qi into the domain of the ying. When
secure the vessels, so the leaking continues and the
wei moves inward toward the domain of the ying,
ying quickly becomes depleted. Thus, the harmony
the blood overheats and the interstitial fluids dry up
of the ying and wei is disrupted. Cinnamon Twig
or degrade into dampness. Without its medium of
Formula rectifies taiyang wind-strike by invigorating
travel, the pathogenic wind and the wei qi become
the flow of wei qi, securing the ying, and supporting
trapped together in the interstices and wheals form
the action of the wei qi to expel outward.
where the movement of wei qi is stuck.
Because ying governs everything we make a part of
Loss of Regulation between Wei and Ying
When wei qi is slightly deficient due to constitu-
us, and wei governs everything we return back to the
tional weakness, or after childbirth or a long illness,
world, the sphere of influence this pair has extends
there may be a loss of regulation between the wei
into the realm of an individual personality’s ex-
and ying qi. Though there may be no exterior symp-
change with the world. A well-functioning ying-wei
toms this patient may present with spontaneous
in a personality allows mutually nourishing interac-
sweating and aversion to wind. A feverish feeling,
tion with others. Cinnamon Twig Formula (Gui Zhi
may also result. By restoring the harmony of the wei
Tang) certainly cannot rectify all improper interac-
and ying qi, the opening and closing of the pores is
tions with the world, but its function to harmonize
properly regulated.
by consolidating ying and invigorating wei can help
with certain psychological boundary issues. It is use- Intermittent Release of Heat
ful when one feels overwhelmed, as if too much is Cinnamon Twig Formula will not only harmonize
coming through without getting processed. the ying and wei qi but also warm and free the heart
yang to treat “running piglet qi” or hot flashes. Not
Think of Cinnamon Twig Formula whenever a clear
all hot flashes are the result of deficiency heat. Many
disharmony exists between the realm of the ying and
cases are due to yang escaping from its proper seat.
that of the wei.
This pathology is similar to running piglet qi, but
Analysis of Classical Indications without the anxiety or sense of fear that accompa-
Taiyang Wind-Strike Pattern nies the former. Extra cinnamon twig (gui zhi) may
In taiyang wind-strike patterns, the wei qi is identi- need to be added to the formula to accomplish this.
fied with the exterior, the ying qi with the interior. In Mismanaged Treatment of Taiyang Illness
order to be susceptible to a “strike” by exterior wind, Cinnamon Twig Formula can be used when some-
there is a preexisting deficiency of wei qi, whether one has been treated for a taiyang stage illness with
temporary or chronic. This weakness of wei qi al- either purgatives or diaphoretics, which fail to com-
lows the exterior wind to penetrate quickly into the pletely eliminate the illness. If the pattern has not
muscle layer. More wei qi is called up to the surface
shifted to another stage, Cinnamon Twig Formula from the muscle layer; it also has been shown to
can be used to resolve the end of the taiyang illness. have anti-inflammatoryiii and analgesiciv proper-
ties. It can therefore be useful in the initial stage of
Taiyang Disease with Absence of Defecation wind-cold-damp painful obstruction (bi zheng, or
for More than Four Days bi syndrome) patterns. These same actions plus the
If a patient has been sick with taiyang disease, if the
formula’s affinity for the taiyang channel makes it
urine is clear and uninhibited, and there has been no
an effective treatment for sciatic pain triggered by
defecation for more than four days, Cinnamon Twig
external wind-cold.v Though it is not strong enough
Formula can be used to rectify the qi in the colon.
to treat the systemic inflammation of rheumatoid
Because the wei qi has a close association with mus- arthritis, this formula can be used as the first line of
cular movement, and because it is the primary qi defense to prevent an attack of painful bi syndrome
involved in guiding things outward to the exterior, sciatica. Another study showed that Cinnamon
wei qi plays a key role in alimentary peristalsis. Both Twig Formula is effective in lowering “arthritic
the fleshy exterior and the colon are comprised of scores” and can decrease the incidence of CIA (col-
epithelial tissue, and when the wei qi becomes en- lagen induced arthritis).vi
tangled with exterior wind, any of the realms the wei
Skin Conditions
qi governs can become affected. If the urine is cloudy
Because the ying and wei meet in the fleshy ex-
or inhibited, there is dampness; if the urine is rough
terior, many skin conditions can be treated with
or dark, there is heat. Cinnamon Twig Formula is
Cinnamon Twig Formula. The classical action of
contraindicated for both heat and dampness, so in
harmonizing the ying and wei assists with resolving
order to effectively us the formula to rectify the peri-
such integumentary conditions as eczema, urticaria,
stalsis in the colon, the urine must remain clear and
non-specific itching, angioedema, allergic purpura
uninhibited.
and even frostbite—which may be treated with Cin-
Modern Applications namon Twig Formula alone or with simple modifi-
Arguably the most adaptive and widely modified cations.vii
formula from the Shang Han Lun, the applications
No modification is necessary to treat acute flare up
for Cinnamon Twig Formula have been broadening
of cold-type (white) eczema or most types of urti-
for centuries. Some of the most common modern
caria. For allergic purpura, add salvia (dan shen). For
applications follow.
frostbite, add ephedra (ma huang), asarum (xi xin),
Upper Respiratory Conditions plus blood invigorating substances such as salvia
Cinnamon Twig Formula has the ability to treat a (dan shen) and carthamus (hong hua).viii
variety of chronic and cold type upper respiratory
Cardiovascular System
conditions. In vitro studies have shown that Cin-
Cinnamon Twig Formula has been shown to in-
namon Twig Formula can inhibit H. pylori, staphy-
crease systolic blood pressure and stroke volume.ix
lococcus aureus, salmonella typhi, and mycobacterium
This is due to cinnamon twig’s ability to dilate ves-
tuberculosis.i
sels and boost heart yang qi.
Along with the traditional actions, these modern
Temperature Regulation, Excessive Sweating
studies show that Cinnamon Twig Formula can be
Cinnamon Twig Formula can reduce or eliminate
used for conditions which involve inflammation or
menopausal hot flashes. Hot flashes result from the
infection such as: allergic rhinitis, influenza, upper
imbalance of yin and yang, interior and exterior, and
respiratory infection, and bronchial asthma.
disharmony between the ying and wei. A properly
Cinnamon Twig Formula
One study reports that Cinnamon Twig Formula functioning relationship between the ying and wei
with the simple addition of magnolia bark (hou po) levels controls the opening and closing of the pores,
was highly effective to treat bronchial asthma in chil- thus affecting the body’s ability to regulate its perspi-
dren, ages 2-10 years. These children had exhibited ration and temperature. Cinnamon Twig Formula
symptoms for up to 6 months. The treatment course also warms the uterus and can help return the yang
was 1-5 days for each case. Only one out of 40 chil- to its proper seat. Because of the formula’s ability
dren showed no improvement.ii to regulate the heart, Cinnamon Twig Formula can
also manage the heart palpitations that often accom-
Rheumatoid Arthritis and Sciatica pany hot flashes.
Cinnamon Twig Formula can dispel wind-cold
5
Psycho-Emotional Issues color, spontaneous sweating, aversion to cold, cold
6
Cinnamon Twig Formula’s application to treat shen hands and feet, and a pale, moist tongue body with
Cinnamon Twig Formula
disturbance is based upon its ability to harmonize white coating. The pulse is usually fine, weak and
the interior ying and exterior wei. When treating slow. Cinnamon Twig Decoction is an appropriate
psycho-emotional conditions with Cinnamon Twig formula for this condition.
Formula, the condition will fall under the general Traditionally, extra cinnamon twig (gui zhi) was
category of “boundary issues.” These patients usu- added to more strongly warm the heart yang. The
ally have a chronic deficiency pattern with a com- additional cinnamon twig not only assists to release
promised ability to keep the exterior out or contain the exterior but also strengthens and moves heart
the interior within. Cinnamon Twig Formula can yang qi. Once the heart yang qi is strong enough, it
be useful, for example, in certain patterns of At- can control kidney water and subdue the upward
tention Deficit Hyperactivity Disorder (ADHD). rushing of qi.
If the patient shows any of the classic signs of ying
and wei imbalance such as mild sweating, poor heat Postpartum Colds and Flu
regulation, catching frequent colds, or constipation Loss of mutual regulation between the ying and
with clear urine, their chronic overstimulation from wei can occur after a serious illness, childbirth, or
the exterior may be rectified with Cinnamon Twig in patients with a weak constitution. In such cases,
Formula. even though there may be no externally contracted
wind-cold, there may still be fever, sweating, and an
A recent study which used Cinnamon Twig For- aversion to wind.
mula to treat ADHD, resulted in 93% amelioration
rate after a 14-21 day course of treatment. The for- Postpartum, the blood is deficient due to loss dur-
mula was somewhat altered in that the recommend- ing the birthing process. The channels and collater-
ed daily dose of each single herb was reduced by one als are open and vulnerable. There is a great loss of
third, except bai shao, which was increased by one qi and blood. The combination of open/vulnerable
third. The subjects of the study were all children, channels and deficient qi and blood compromise
from 2-13 years old and had exhibited symptoms of the ying and wei harmony, making easy for the
ADHD for 5 days up to four years. Those that did mother to be affected by wind-strike. Cinnamon
not respond had exhibited symptoms for 3+ years.x Twig Formula is administered to treat the event of
wind-strike, and also as a preventative. It is the for-
Some schools of thought suggest that shen condi- mula of choice for postpartum exterior conditions
tions require a smaller dosage than physical/physi- also because of its ability to warm the uterus.
ological conditions. The reasoning is that, the spirit,
being more refined than material substance, is more Testicular Pain
easily influenced on the level of the subtle. Typically, Most testicular pain is caused by cold in the
the “spirit dose” is about ⅓ of the of the “standard urinary bladder/kidney complex. Cinnamon Twig
dose.” Formula was tested to treat testicular pain because
of its affinity for the urinary bladder (foot taiyang)
Flushing Up of Qi (Ben Tu, Running Piglet channel and its ability to warm and expel patho-
Disorder) gens from the channels and collaterals. One study
This pattern is one in which a deficiency of heart treated 20 patients with a base of Cinnamon Twig
yang fails to warm kidney water: heart yang defi- Formula modified with chinaberry fruit (chuan lian
ciency with lower burner cold. There may also be a zi) and dryopteris root (guan zhong). Marked relief
pre-existing kidney yang qi deficiency. In any case, was obtained after administering the formula for a
heart fire is unable to warm kidney water, resulting period ranging from 6 to 32 days.xi
in water rebelling upwards, which is experienced as
a rushing upward of energy, traditionally described Pediatric Enuresis
in China as ‘running piglet qi’. This upward rushing Most enuresis in children is due to either an insuf-
of energy should not be confused with menopausal ficiency of yang qi or the presence of external cold in
hot flashes, but is more akin to heart palpitations the urinary bladder/kidney. Cinnamon Twig For-
with anxiety. In this pattern the patient presents mula can be used to warm the yang and expel cold.
with heart palpitations, a tendency to be easily In one study, 30 children 3-6 years old were treated
frightened, fatigue with desire to sleep (but possi- with Cinnamon Twig Formula modified with black
bly difficulty in falling asleep,) a bright white facial cardamom (yi zhi), cuscuta (tu si zi) and Chinese
quince fruit (mu gua). Fifteen cases showed significant Jade Windscreen Formula (Yu Ping Feng San)
improvement, 11 showed moderate improvement, Jade Windscreen Formula strengthens the wei qi
and in 4 cases there was complete resolution.xii and consolidates the exterior. It can be taken for long
Formula Comparisons periods of time to build up wei qi, but should be dis-
Ephedra Decoction (Ma Huang Tang) continued during the course of an exterior invasion.
Ephedra Decoction is for taiyang cold damage, while Cinnamon Twig Formula is appropriate while exte-
Cinnamon Twig Formula is for taiyang wind-strike. rior symptoms are present and during the resolution
The essential difference is that in taiyang cold dam- stage.
age, the wei qi is considered to be sufficiently strong. Gan Mao Ling Formula (Gan Mao Ling Pian), Vi-
Some of the symptoms manifest because the struggle ola Clear Fire Formula (Di Ding Qing Huo Pian),
between the wei qi and the cold pathogen is fierce. Yin Chiao Formula (Yin Qiao San), and Zhong
This struggle cannot be fierce if the wei qi is insuf- Gan Ling Formula (Zhong Gan Ling Pian)
ficient. In the case of insufficient wei qi, wind pen- What all these formulas have in common is that they
etrates easily to the fleshy exterior of the body, caus- possess strong anti-viral actions and are therefore
ing leaking of jin fluid in the form of sweat. If there used to treat externally contracted pathogens. They
is sweating, Ephedra Decoction is contraindicated. are all cold natured and are most appropriate when
(See introduction for more details.) used to treat warm pathogens. When used to treat a
cold pathogen, these formulas can actually drive the
Cinnamon D Formula cold deeper into the body or lock it in place. Cinna-
(Gui Zhi Jia Long Gu Mu Li Tang ) mon Twig Formula, on the other hand, is warming
Cinnamon D Formula is a modification of Cinna- and therefore more effective and appropriate against
mon Twig Formula. The fresh ginger (sheng jiang) is cold pathogens.
replaced with dried ginger (gan jiang); dragon bone
(long gu) and oyster shell (mu li) have been added so
Endnotes
that the formula can harmonize heart and kidney.
These modifications focus the formula on specific
i
Zhong Yao Yao Li Yu Ying Yong (Pharmacology and Applications
of Chinese Herbs) 1987; 3 (3):1.
organs rather than upon the ying and wei. Sheng jiang ii
Si Chuan Zhong Yi (Sichuan Chinese Medicine) 1998; 9:42.
releases the exterior, but gan jiang warms the interior.
Long gu and mu li settle and calm the spirit, benefit Zhong Cheng Yao Yan Jiu (Research of Chinese Patent Medi-
iii
Bupleurum and Cinnamon Formula is a combina- mulas and Strategies, 2nd edition, Eastland Press, 2009.
tion of Cinnamon Twig Formula (Gui Zhi Tang) Zhong Cheng Yao Yan Jiu (Research of Chinese Patent Medi-
viii
current taiyang and shaoyang stages of exterior inva- culatory Parameters”, Acupuncture and Electro-therapeutics
sion. In Six Stage Theory, the passage from one stage Research 1999;24(1):11-28.
to another is not always cut and dry. There can be x
Hu Bei Zhong Yi Za Zhi (Hubei Journal of Chinese Medicine)
simultaneous manifestations. The Cinnamon Twig 1994; 3:33.
Formula addresses taiyang symptoms like chills and xi
Zhe Jiang Zhong Yi Za Zhi (Zhejiang Journal of Chinese Medi-
fever, while the Minor Bupleurum Formula ad- cine) 1985;3:109
dresses shaoyang symptoms like pain and crackling in Wang Wei and Wang Yei, “The Treatment of 30 Cases of Long-
xii
the joints, difficulty twisting, fullness in the chest and term Pediatric Enuresis with Gui Zhi Tang,” Ji Lin Zhong Yi Yao
epigastric pain. (Jilin Chinese Medicine and Herbology) 1998;4:36.
7
Useful Combinations
8
Cinnamon Twig Formula
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