STH 411 C.

A Test

INTERMEDIARY METABOLISM

INSTRUCTION: Answer all questions

SECTION “A”

1. The main intermediate of all metabolic pathways includes, except

(a) AcetylcoA (b) Oxaloacetate (c) Pyruvate (d) Glucose

2. It acts as a link between catabolic and anabolic pathways

(a) Urea cycle (b) Nitrogen cycle (c) Citric acid cycle (d) Water cycle

3. The following are the influx of TCA cycle intermediates, except

(a) Heme (b) Propionyl CoA (c)Tyrosine (d) Pyruvate
4. A nucleoside can be composed of, except

(a) Purine base (b) pentose sugar (c) Phosphate group (c)Pyrimidine

5. Which of the following is not a feature of Watson crick model of DNA?

(a) Helical (b) Two strands are held by H-bond (c) A + T = C + T (d) Two strands are right handed

6. ________ and ________ atoms are contributed to the structure of the purine ring by amino acids

7.__________________ and _________________ are the sources of C and N of pyrimidine ring

8. __________________is the starting material in salvage pathway for purine biosynthesis

9. During purine biosynthesis, Glycine condenses with PRA using ATP to form ____________

10. _____ and _____ are the two other main purine nucleotides

11. ______________ is the final excretory product of purine metabolism in humans

12.__________ is due to the accumulation of urate crystals in synovial fluids

13. DNA strands for replication for replication process are sepereted by the enzyme________

14. The small fragments of DNA produced during replication are called____________
15. The problem of supercoiling in DNA replication is overcome by a group of enzymes
namely______________

16. The factories for protein biosynthesis are________________

17. In prokaryotes transcription and translation occurs simultaneously. T/F

18. Degeneracy of the genetic code means that codons are not ambiguous. T/F

19. Translation results in the formation of a protein molecule. T/F

20. Termination of protein biosynthesis requires presence of rho factor. T/F

SECTION 'B'

1a. Explain how de novo purine ribonucleotide biosynthesis is regulated

1b. Describe the synthesis of AMP and GMP from IMP

2. Describe central of molecular biology.