Analysts should inform themselves about the properties, hazards, and proper disposal methods of this material

and other chemicals used in its analyses from an authoritative source such as the Safety Data Sheet (SDS).

Monograph

pubs.acs.org/doi/book/10.1021/acsreagents

Acetone
(2-Propanone)
Part 4, Monographs for Reagent Chemicals: General Descriptions, Specifications, and Tests
eISBN: 9780841230460
Tom Tyner Chair, ACS Committee on Analytical Reagents
James Francis Secretary, ACS Committee on Analytical Reagents

A u t h o r i t a t i v e Ve r s i o n : This version is current as of 01 Jun 2016.

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ABSTRACT
Downloaded via 80.15.95.142 on October 20, 2023 at 13:09:01 (UTC).

This monograph for Acetone provides, in addition to common physical constants, a general description including typical
appearance, applications, change in state (approximate), aqueous solubility, and density. The monograph also details
the following specifications and corresponding tests for verifying that a substance meets ACS Reagent Grade
specifications including: Assay, Isopropyl Alcohol, Methanol, Color (APHA), Residue after Evaporation, Solubility in
Water, Titrable Acid, Titrable Base, Aldehyde, Substances Reducing Permanganate, Water, and Ultraviolet
Spectrophotometry.

(CH3)2CO Formula Wt 58.08 CAS No.67-64-1

UPDATES & ADDITIONS

Published Authoritative Expired Type Summary

28 Feb 2017 01 Jun 2016 Original First on-line publication,
based on 11th ed.

Suitable for general use or in ultraviolet spectrophotometry. Product labeling shall designate the uses for which suitability is
represented on the basis of meeting the relevant specifications and tests. The ultraviolet spectrophotometry specifications
include all of the specifications for general use.

GENERAL DESCRIPTION

Typical appearance . . . . . . . . . . . . . . . . . . . liquid with a characteristic odor

Applications . . . . . . . . . . . . . . . . . . . . . . . . liquid chromatography; cleaning glassware; extraction of solid waste
Change in state (approximate) . . . . . . . . . . . . boiling point, 56 °C
Aqueous solubility . . . . . . . . . . . . . . . . . . . . miscible with water

DOI: 10.1021/acsreagents.4005.2016061
© 2017 American Chemical Society A ACS Reagent Chemicals, Part 4

ACS Reagent Chemicals

ACS Reagent Chemicals; American Chemical Society: Washington, DC, 2017.
 Analysts should inform themselves about the properties, hazards, and proper disposal methods of this material
and other chemicals used in its analyses from an authoritative source such as the Safety Data Sheet (SDS).

ACS Reagent Chemicals Monograph

pubs.acs.org/doi/book/10.1021/acsreagents

Density . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.79

SPECIFICATIONS

General Use

Assay . . . . . . . . . . . . . . . . . . . . . . . . . . . ≥99.5% (CH3)2CO

Maximum Allowable
Color (APHA) . . . . . . . . . . . . . . . . . . . . . . 10
Residue after evaporation . . . . . . . . . . . . . . 0.001%
Solubility in water . . . . . . . . . . . . . . . . . . . Passes test
Titrable acid . . . . . . . . . . . . . . . . . . . . . . 0.0003 meq/g
Titrable base . . . . . . . . . . . . . . . . . . . . . . 0.0006 meq/g
Aldehyde (as HCHO). . . . . . . . . . . . . . . . . . 0.002%
Isopropyl alcohol. . . . . . . . . . . . . . . . . . . . 0.05%
Methanol . . . . . . . . . . . . . . . . . . . . . . . . . 0.05%
Substances reducing permanganate . . . . . . . . Passes test
Water (H2O) . . . . . . . . . . . . . . . . . . . . . . . 0.5%

Specific Use

Ultraviolet Spectrophotometry
Wavelength (nm) Absorbance (AU)
400 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.01
350 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.02
340 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.10
330 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.00

TESTS

Assay, Isopropyl Alcohol, and Methanol

Analyze the sample by gas chromatography using the general parameters cited in [Part 2: Chromatography; Recommended
Procedures; Gas Chromatography]. The following specific conditions are also required.

Column . . . . . . . . . . . . . . . . . . . . . . . . . . Type I, methyl silicone

Measure the area under all peaks, and calculate the area percent for acetone, isopropyl alcohol, and methanol. Correct for
water content.

DOI: 10.1021/acsreagents.4005.2016061
© 2017 American Chemical Society B ACS Reagent Chemicals, Part 4

ACS Reagent Chemicals

ACS Reagent Chemicals; American Chemical Society: Washington, DC, 2017.
 Analysts should inform themselves about the properties, hazards, and proper disposal methods of this material
and other chemicals used in its analyses from an authoritative source such as the Safety Data Sheet (SDS).

ACS Reagent Chemicals Monograph

pubs.acs.org/doi/book/10.1021/acsreagents

Color (APHA)
[Part 2: Measurement of Physical Properties; Color (APHA); Procedure for Color (APHA)].

Residue after Evaporation

[Part 2: Gravimetric Methods; Residue after Evaporation]. Evaporate 100 g (127 mL) to dryness in a tared, preconditioned
dish on a hot plate (~100 °C), and dry the residue at 105 °C for 30 min.

Solubility in Water
Mix 30 g (38 mL) with 38 mL of carbon dioxide-free water. The solution should remain clear for 30 min. Reserve this solution
for the test for titrable acid.

Titrable Acid
Add 0.10 mL of phenolphthalein indicator solution to the solution prepared in the preceding test. Not more than 1.0 mL of
0.01 N sodium hydroxide should be required to produce a pink color.

Titrable Base
Mix 18 g (23 mL) with 25 mL of water, and add 0.05 mL of methyl red indicator solution. Not more than 1.0 mL of 0.01 N
hydrochloric acid should be required to produce a red color.

Aldehyde
Dilute 2 g (2.5 mL) with water to 10 mL. Prepare a standard containing 0.04 mg of formaldehyde in 10 mL of water and a
complete reagent blank in 10 mL of water alone. To each, add 0.15 mL of a freshly prepared 5% solution of 5,5-dimethyl-
1,3-cyclohexanedione in alcohol. Evaporate each on a hot plate (~100 °C) until the acetone is volatilized. Dilute each with
water to 10 mL, and cool quickly in an ice bath while stirring vigorously. Any turbidity in the solution of the sample should
not exceed that in the standard. If any turbidity develops in the reagent blank, the 5,5-dimethyl-1,3-cyclohexanedione
should be discarded, and the entire test rerun with a fresh solution.

Substances Reducing Permanganate

Add 0.05 mL of 0.1 N potassium permanganate to 10 mL of the sample, and allow to stand for 15 min at 25 °C. The pink
color should not be entirely discharged, when compared with an equal volume of water.

Water
[Part 2: Titrimetric Methods; Water by the Karl Fischer Method; Volumetric Procedure; Volumetric Procedure for Samples
Using Karl Fischer Reagent, Method 1]. Use 25 mL (20 g) of the sample and a methanol-free system to prevent ketal
formation with liberation of water.

Ultraviolet Spectrophotometry
Use the procedure in

DOI: 10.1021/acsreagents.4005.2016061
© 2017 American Chemical Society C ACS Reagent Chemicals, Part 4

ACS Reagent Chemicals

ACS Reagent Chemicals; American Chemical Society: Washington, DC, 2017.
 Analysts should inform themselves about the properties, hazards, and proper disposal methods of this material
and other chemicals used in its analyses from an authoritative source such as the Safety Data Sheet (SDS).

ACS Reagent Chemicals Monograph

pubs.acs.org/doi/book/10.1021/acsreagents

[Part 2: Chromatography; Recommended Procedures; LC Suitability]; Procedure for Absorbance to determine the
absorbance.

DOI: 10.1021/acsreagents.4005.2016061
© 2017 American Chemical Society D ACS Reagent Chemicals, Part 4

ACS Reagent Chemicals

ACS Reagent Chemicals; American Chemical Society: Washington, DC, 2017.