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Bulimia nervosa is one of the most common eating disorders, with a lifetime prevalence estimated to be
around 1-2% in the general population. It is classified under the category of eating disorders in the
Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which distinguishes between two
subtypes: purging and non-purging bulimia nervosa.
The etiology of bulimia nervosa is multifactorial, involving genetic, biological, psychological, and
environmental factors. Genetic studies have identified several genes associated with eating disorders,
highlighting the hereditary component of bulimia nervosa. Psychological factors, such as body image
dissatisfaction, low self-esteem, and perfectionism, also play a significant role in its development.
Environmental factors, including societal pressures, dieting culture, and trauma, contribute to the onset
and maintenance of the disorder.
Pathophysiology
The pathophysiology of bulimia nervosa involves dysregulation of appetite and satiety mechanisms, as
well as alterations in brain neurotransmitter systems, such as serotonin and dopamine. Binge eating
episodes are driven by intense cravings for high-calorie foods, followed by feelings of guilt, shame, and
loss of control. Compensatory behaviors are employed to alleviate distress and mitigate weight gain.
Clinical presentation of bulimia nervosa includes recurrent episodes of binge eating, typically
accompanied by a sense of lack of control and distress. Compensatory behaviors, such as self-induced
vomiting, excessive exercise, or laxative misuse, are used to counteract the caloric intake from binge
eating. Diagnosis is based on criteria outlined in the DSM-5, which include the frequency and severity of
binge eating and compensatory behaviors, as well as associated psychological and physical symptoms.
Treatment Modalities
Conclusion
Bulimia nervosa is a complex eating disorder with significant medical and psychological consequences.
Early detection, intervention, and ongoing support are essential for successful recovery and long-term
management of the disorder. Continued research efforts are needed to further elucidate its underlying
mechanisms and develop more effective treatment strategies.