Frutos da árvore do conhecimento

O futuro da Suplementação e
da ciência na nutrição
esportiva
futuro
• Bola de cristal?
• Pesquisa básica e animais – precedem pesquisa clinica.
• O que ocorre aqui fora, vira lá de dentro dos laboratórios.
• Futuro não é previsível, é dedutível.
Ciência
• O que há de novo em suplementos na área do esporte?
• O que a indústria está fazendo?
• Soma de efeitos de produtos antigos.
• Precursores ou resultantes metabólicos.
• O que os cientistas estão pesquisando?
• Fisiologia.
• Comparando com exemplos.
• Detalhes.
Referencias como espelho metabólico
• Maior “atleta” anabolizante que existe?
• Câncer.
• Maior “atleta” aeróbio (ácidos graxos) que existe ?
• Coração
• Maior “atleta” aeróbio (glicose) que existe ?
• Cérebro. .
O Anabolismo
Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell?

Sports Medicine (2022) 52:2569–2578

An essential role for de novo biosynthesis of L-serine in CNS development

Asia Pac J Clin Nutr 2008;17 (S1):312-315

The role of methionine on metabolism, oxidative stress, and diseases

Amino Acids DOI 10.1007/s00726-017-2494-2

Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects

Front. Immunol. 12:688910.

Glutamine addiction: a new therapeutic target in cancer

Trends in Biochemical Sciences 35 (2010) 427–433

Metabolic Reprogramming and Molecular Rewiring in Cancer: Therapeutic Opportunities

Indones Biomed J. 2021; 13(2): 114-39

Does a Hypertrophying Muscle Fibre Reprogramme its Metabolism Similar to a Cancer Cell?

Sports Medicine (2022) 52:2569–2578

The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults

Nutrients 2023, 15, 3874

The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults

Nutrients 2023, 15, 3874

The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults

Nutrients 2023, 15, 3874

The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults

Nutrients 2023, 15, 3874

The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults

Nutrients 2023, 15, 3874

The Effect of Choline and Resistance Training on Strength and Lean Mass in Older Adults

Nutrients 2023, 15, 3874

O aeróbio
CLINICAL BIOENERGETICS

ISBN: 978-0-12-819621-2
O aeróbio fundista – ácidos
graxos
Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine
in regulation of cardiac cell function

Amino Acids (2011) 40:1333–1348

Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine
in regulation of cardiac cell function

Amino Acids (2011) 40:1333–1348

A comprehensive review of the bi oenergetics of fatty acidand glucose metabolism in the healthy and failing heart
in nondiabetic condition

Heart Fail Rev DOI 10.1007/s10741-017-9623-6

CLINICAL BIOENERGETICS

ISBN: 978-0-12-819621-2
O aeróbio –(glicose)
BRAIN GLUCOSE METABOLISM: INTEGRATION OF ENERGETICS WITH FUNCTION

Physiol Rev 99: 949–1045, 2019

BRAIN GLUCOSE METABOLISM: INTEGRATION OF ENERGETICS WITH FUNCTION

Physiol Rev 99: 949–1045, 2019

Metabolismo
Controle
• Inflamação – diminuir ação da cox 2 , aumentar ação da cox 1 e
geradores de endocanabionoides.
• Controle metabólico – ppars também controlam inflamação.
• Miocinas como modulatores do metabolismo no momento de
“repouso”.
• Opções futuras...
An insight to treat cardiovascular diseases through phytochemicals targeting PPAR-α

Molecular and Cellular Biochemistry

An insight to treat cardiovascular diseases through phytochemicals targeting PPAR-α

Molecular and Cellular Biochemistry

O controle
• PPAR gama – glicose e inflamação.
• PPAR alfa – metabolismo oxidativo de ácidos graxos.
• PI3K, AKT, mTOR.
• AMPK-PGF-1-alfa.
• Transportadores de membrana.
• Nanotecnologia para vetorização.
fitoterapia
The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise:
A Review

Foods 2023, 12, 916

Deciphering the Role of Polyphenols in Sports Performance: From Nutritional Genomics to the Gut
Microbiota toward Phytonutritional Epigenomics

Nutrients 2020, 12, 1265

The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise:
A Review

Foods 2023, 12, 916

The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise:
A Review

Foods 2023, 12, 916

The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise:
A Review

Foods 2023, 12, 916

The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise:
A Review

Foods 2023, 12, 916

The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise:
A Review

Foods 2023, 12, 916

A proprietary blend of Sphaeranthus indicus flower head and Mangifera indica bark extracts increases muscle strength and
enhances endurance in young male volunteers: a randomized, double-blinded, placebo-controlled trial

Food & Nutrition Research 2023

A proprietary blend of Sphaeranthus indicus flower head and Mangifera indica bark extracts increases muscle strength and
enhances endurance in young male volunteers: a randomized, double-blinded, placebo-controlled trial

Food & Nutrition Research 2023

A proprietary blend of Sphaeranthus indicus flower head and Mangifera indica bark extracts increases muscle strength and
enhances endurance in young male volunteers: a randomized, double-blinded, placebo-controlled trial

Food & Nutrition Research 2023

A proprietary blend of Sphaeranthus indicus flower head and Mangifera indica bark extracts increases muscle strength and
enhances endurance in young male volunteers: a randomized, double-blinded, placebo-controlled trial

Food & Nutrition Research 2023

A proprietary blend of Sphaeranthus indicus flower head and Mangifera indica bark extracts increases muscle strength and
enhances endurance in young male volunteers: a randomized, double-blinded, placebo-controlled trial

Food & Nutrition Research 2023

 FNDC5/Irisin: Physiology and Pathophysiology

Figure 1. Schematic representation of FNDC5 structure and formation of irisin. Molecules 2022, 27, 1118
Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function
and Health in Men and Women

J Altern Complement Integr Med 2017, 3: 034

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function
and Health in Men and Women

J Altern Complement Integr Med 2017, 3: 034

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function
and Health in Men and Women

J Altern Complement Integr Med 2017, 3: 034

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function
and Health in Men and Women

J Altern Complement Integr Med 2017, 3: 034

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function
and Health in Men and Women

J Altern Complement Integr Med 2017, 3: 034

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function
and Health in Men and Women

J Altern Complement Integr Med 2017, 3: 034

Posologia
Creatine O’Clock: Does Timing of Ingestion Really Influence Muscle Mass and Performance?

Front. Sports Act. Living 4:893714.

Timing of ergogenic aids and micronutrients on muscle and exercise performance

Journal of the International Society of Sports Nutrition (2019) 16:37

Pensar.
• Idosos – fazer menos síntese – como menos serina, menos glicina,
menos cisteína e menos NAC.
• Idosos – fazem menos creatina.
• Aumentar receptores nucleares – PPAR – gamma – PPAR – alfa.
• Perfusão sanguínea e recuperação
Futuro
• Suplementos antigos repaginados com a síntese química, a ligação e a
nanotecnologia.
• Sistema de liberação programada ou melhorada.
• Fitoterápicos.
• O antigo repaginado.
• O novo? Difícil sair algo.
• Mas em ciência não existe verdade absoluta, apenas momentânea.
OBRIGADO!