IMMUNOLOGY

MCQ

REVISION

DR. POSSIBILITY
1) What type of immunity results from vaccination?
A) innate immunity
B) naturally acquired active immunity
C) naturally acquired passive immunity
D) artificially acquired active immunity
E) artificially acquired passive immunity
=D
2) What type of immunity results from transfer of antibodies from one individual to a
susceptible individual by means of injection?
A) innate immunity
B) naturally acquired active immunity
C) naturally acquired passive immunity
D) artificially acquired active immunity
E) artificially acquired passive immunity
3) What type of immunity results from recovery from mumps?
A) innate immunity
B) naturally acquired active immunity
C) naturally acquired passive immunity
D) artificially acquired active immunity
E) artificially acquired passive immunity
=B
4) Which of the following is the best definition of epitope?
A) specific regions on antigens that interact with T-cell receptors
B) specific regions on antigens that interact with MHC class molecules
C) specific regions on antigens that interact with
D) specific regions on antigens that interact with antibodies
E) specific regions on antigens that interact with
=D
5) Newborns' immunity due to the transfer of antibodies across the placenta is an example of
A) innate immunity
B) naturally acquired active immunity
C) naturally acquired passive immunity-
D) artificially acquired active immunity.
E) artificially acquired passive immunity.
=C
6) Which of the following statements is NOT a possible outcome of antigen-antibody
reaction?
A) clonal deletion
B) activation of complement
D) ADCC
E) agglutination
=A
7) Which of the following cells is NOT an APC?
A) dentritic cells
B) macrophages
C) immature B cells
D) natural killer cells
E) None of the answers is correct; all of these are APCs.
=D
8) When an antibody binds to a toxin, the resulting action is referred to
A) agglutination.
C) ADCC
D) apoptosis.
E) neutralization.
=E
9) CD4+ T cells are activated by
A) interaction between CD4+ and MHC II.
B) interaction between TCRs and MHC II.
C) cytokines released by dendritic cells.
D) cytokines released by B cells.
E) complement
=A
10) Which of the following recognizes antigens displayed on host cells with MHC II?
A) TC cell
B) B cell
C) TH cell
D) natural killer cell
E) basophil
=C
I11) The specificity of an antibody is due to
A) its valence.
B) the H chains.
C) the L chains.
D) the constant portions of the H and L chains.
E) the variable portions of the H and L chains.
=E
12) Which of the following is NOT a characteristic of B cells?
A) They originate in bone marrow.
B) They have antibodies on their surfaces.
C) They are responsible for the memory response.
D) They are responsible for antibody formation.
E) They recognize antigens associated with MHC l.
=E
13) Which of the following is NOT a characteristic of cellular immunity?
A) The cells originate in bone marrow.
B) Cells are processed in the thymus gland.
C) It can inhibit the immune response.
D) B cells make antibodies.
E) T cells react with antigens
=D
14) Plasma cells are activated by a(n)
A) antigen
B) T cell
C) B cell.
D) memory celL
E) APC
=A
15) The antibodies found in mucus, saliva, and tears are
A) IgG.
B) IgM
C) IgA
D) IgD
C) IgE
=C
16) The antibodies found on the surface of B cells, and which always exist as monomers, are
A) IgG
B) IgA
C) IgD
D) IgE
=D
17) The antibodies that can bind to large parasites are
A) IgG
B) IgM
C) IgA
D) IgD
E) lgE.
=E
18) In addition to IgG, the antibcxiies that can fix complement are
A) IgM-
B) IgA.
C) lgD.
D) lgE.
E) None of the answers is correct
=A
19) Large antibodies that agglutinate antigens are
A) IgG
B) IgM
C) IgA.
D) lgD.
E) lgE.
=B
20) The most abundant class of antibodies in serum
A) IgG
B) IgM
C) IgA
D) lgD
E) lgE
=A
21) Which of the following statements is FALSE?
A) The variable region of a heavy chain binds with antigen-
B) The variable region of a light chain binds with antigen.
C) The Fc region attaches to a host cell-
D) The constant region of a heavy chain is the same for all antibodies.
E) All of the answers are correct
=D
22) Which of the following is the best definition of antigen?
A) something foreign in the body
B) a chemical that elicits an antibody response and can combine with these antibodies
C) a chemical that combines with antibodies
D) a pathogen
E) a protein that combines with antibodies
=B
23) Which of the following WBCs are NOT lymphocytes?
A) cytotoxic T cells
B) helper T cells
C) NK cells
D) M cells
E) B cells
=D
24) The following events elicit an antibody response What is the third step?
A) Antigen-digest goes to surface of APC
B) APC phagocytizes antigen-
C) B cell is activated-
D) TH cell recognizes antigen- digest and MHC II
E) TH cell produces cytokines.
=D
25) Which of the following bacterial components would most likely result in B cell stimulation
by T-independent antigens?
A) capsule
B) flagellum
C) pili
D) ribosome
E) plasmid
=A
26) The presence of which of the following indicates a current infection rather than a
previous infection or vaccination?
A) IgA
B) IgG
C) IgM
D) lgD
=C
27) Which of the following destroys virus-infected cells?
A) CTL
B) Treg
C) TH
D) dendritic cells
E) B cells
=A
28) The following events occur in cellular immunity What is the third step?
A) Antibodies are produced-
B) Dendritic cell takes up antigen-
C) Antigen enters M cell.
D) TH cell produces cytokines-
E) TH cells proliferate.
=E
27) Cytokines released by TH1 cells
A) activate CD8+ cells to CTLs.
B) convert THI cells to TH2 cells.
C) convert TH2 cells to TH1 cells.
D) kill parasites.
E) convert B cells to T cells.
=A
28) Which one of the following causes transmembrane channels in target cells?
A) granzymes
B) hapten
C) IL-I
D) IL-2
E) perforin
=E
29) At a minimum, the human immune system is capable of recognizing approximately how
many different antigens?
A) 105
B) 1010
C) 1015
D) 1020
E) 1025
=C
30) Thymic selection
A) destroys T cells that do not recognize self- molecules of MHC
B) destroys B cells that make antibodies against self-
C) destroys MHC molecules.
D) destroys CD4+ cells that attack self-
E) activates B cells
=A
31) Thymic selection
A) destroys T cells that do not recognize self-molecules of MHC
B) destroys B cells that make antibodies against self.
C) destroys MHC molecules.
D) destroys CD4+ cells that attack self.
E) activates B cells
=A
32) Which of the following statements about natural killer cells is FALSE?
A) They destroy virus-infected cells.
B) They destroy tumor cells.
C) They destroy cells lacking MHC l.
D) They are stimulated by an antigen.
E) None of the answers are correct; all of these statements are true.
=D
33) An antibod ß Fc region can be bound by
A) antibodies.
B) macrophages
C) T helper cells-
D) B cells
E) CTLs.
=D
34) A Treg cell deficiency could result in
A) increased number of viral infections.
B) increased number of bacterial infections.
C) autoimmunity
D) increased severity of bacterial infections-
E) transplant rejection
=C
35) ADCC is a process that is most effective in destroying
A) Eukaryotic pathogens_
B) virus-infected host cells-
C) Extracellular Viruses.
D) Bacterial pathogens.
E) bacterial toxins
=A
36) IL-2 produced by TH cells,
A) activates macrophages
B) stimulates TH cell maturation.
C) causes phagocytosis.
D) activates antigen- presenting cells
E) activates TC cells to CTLs.
=B
37) Which of the following statements about IL-12 is FALSE?
A) It activates macrophages.
B) It inhibits some tumor cells.
C) It activates the TH1 pathway.
D) It causes autoimmune diseases.
E) It causes TH cells to respond to HIV.
=D
38) If a person shows production of interferons in his body, the chances are that he has got an
infection:
a. tanatus
b. malaria
c. typhoid
d. measles
=D
40) An antibody has:
a. 2 Fab region and an Fc region
b. an Fab region and an Fc region
c. 2 Fab regions and 2 Fc regions
d. many Fab regions and many Fc regions
=A
41) Fc region is involved in:
a. cell surface receptor binding
b. Complement activation
c. Determining diffusivity of antibody molecule
d. all of these
=D

42) The ability of antigen to stimulate antibody production is called:

a- affinity
b antigenicity
e- elicitation
d. none of these
=B
43) The hypervariable region resides in the:
a. N terminal region of light chain
b. N terminal region of light and heavy chain
c. C terminal region of light chain
d. C terminal region of light chain and heavy chain
=B

44) The hypervariable region of antibody consists of:

a. 5-10 amino acids that form antigen- binding site
b. 50-100 amino acids that form antigen binding site
c. 5-10 amino acids that forms the antibody binding site
d. a part of constant region of heavy and light chain
=A
45) Which of the following statements are true regarding IgM?
a. IgM is a pentamer and is the largest lg and called as “natural antibody”
b. Exists as monomer on B-cell surface
c. IgM is involved in early primary immune response
d. all of these
=D

46) Which of the following is achapten?

a. cynide
b. paracetamol
c. Penicillin
d. none of these
=C
47) Antigens can be
a. proteins
b. carbohydrate
c. nucleic acids
d. all of these
=D

48) A complete antigen is capable of

a. inducing an immune response
b. can interact with antibody
c. induces antibody production
d. all of these
=D
49) Which of the following statement is true?
a. All immunogenicity are antigens but all antigens are not immunogens
b. all immunogens are antigens and all antigens are immunogens
c. all immunogens are not antigens but all antigens are immunogens
d all immunogens are proteins and all proteins are immunogens
=A

50) Which of the statements are true regarding antigen

a. generally self-molecules and molecules with low molecular weight are non-
immunogenic
b. an antigen generally has many epitopes
c. Heteropolymers are more immunogenic than homopolymers
d all of these
=D
51) Skin prevents pathogen entry:
a. dead cells of the skin outer layer prevents pathogen entry
b. skin secretes oil by sebaceous gland that makes surface acidic
c. skin secretes sweat by sudoriferous gland that makes surface acidic
d all of these
=D

52) Bodies internal defense or second line of defense include:

a. phagocytes
b. fever
c. interferons
d. all of these
=C
53) Neutrophils are
a. phagocytes
b. short lived leukocytes
c. involved in second line of defense
d. all of these
=D

54) The functions of macrophages include:

a. phagocytosis
b. Antigen presenting cells
c. Cytokine production
d. all of these
=D
55) Which of the following statements are true regarding adaptive immunity:
a. prior exposure to antigen is essential
b. prior exposure to antigen is not essential
c. it is a non-specific defense mechanism
d macrophages are the major cells involved
=A

56) The characteristics of passive immunity include:

a. immediate relief
b. no immunologic memory
c. resistance for a short period only
d. all of these
=D
57) All of the following are autoimmune disorders except:
a. Graves disease
b. SCID
c. Rheumatoid arthritis
d. Addison's disease
=B

58) SCID can occur due to the absence of an enzyme:

a. Adenosine deaminase
B. Guanosine deaminase
c. phosphorylase
d thymidine deaminase
=A
59) immune disorders include:
a. hypersensitivity
b. auto-immune diseases
c. immunodeficiency
d. all of these
=D

60) The inability to distinguish between self-cells and non- self-cells may lead to:
a. hypersensitivity
b. auto-immune diseases
c. immunodeficiency
d. Tolerance
=B
THANK YOU!!!