PART

PROPER USE
OF ANTIBIOTICS
SERIES By: Nathan muyinda

0701 080340 busogahealthforum

 Drug: CEFIXIME

Original Brand: Suprax

Class: 3rd generation cephalosporins
Year of approval: 2012
Innovator company: Lupin ltd

Nathan Muyinda Busoga Health Forum

 Form and strength:
Tablets: 200mg, 400mg Capsules: 200mg, 400mg
Dry powder for oral suspension: 50mg/5ml,
100mg/5ml

Spectrum of activity
Gram positive Gram negative Others

Streptococcus agalactiae Haemophilus para influenza None

Streptococcus pneumoniae E. coli
Streptococcus pyogenes Klebsiella pneumoniae
Neisseria gonorrheae
Proteus mirabilis
Proteus vulgaris
Moraxella catarrhalis
Salmonella typhi
Shigella species

Nathan Muyinda Busoga Health Forum

 Indications
• Tonsillitis
• Pharyngitis
• Typhoid
• Acute otitis media
• Gonorrhoea
• Urinary tract infection
• Community acquired Pneumonia
• Acute bronchitis
• Pelvic inflammatory disease.

Nathan Muyinda Busoga Health Forum

 Dosage guide
Infection Dose Frequency Duration

Gonorrhea 400mg Single dose 1 day

incombination with
doxycycline
or azithromycin

Uncomplicated PID 400mg Every 24 hours 3 days

incombination with
other antibiotics

Urinary tract Infection 400mg Every 24 hours 7 -10 days

or 200mg or Every 12 hours

Bronchitis 400mg Every 24 hours 10 days

or 200mg or Every 12 hours

Otitis media 8mg/kg Every 24 hours 5 -10 days

Pneumonia 400mg Every 24 hours 7 -14 days

Typhoid 400mg Every 24 hours 10 -14 days

Pharyngitis and 400mg Every 24 hours 10 days

Tonsillitis

Nathan Muyinda Busoga Health Forum

 Side effects
• Nausea and vomiting • Urticaria
• Diarrhoea • Headache
• Abdominal pain • Dizziness
• Oral candidiasis • Vaginal candidiasis

Contraindications
Do not give cefixime to patients with known allergy
to cephalosporins or penicillins.

Nathan Muyinda Busoga Health Forum

 Special groups
Category Remarks

Pregnancy Cefixime is safe for use during pregnancy

Breast feeding Limited information is available regarding

the safety of cefixime during breast feeding,
advise the mother to suspend breast feeding
until treatment is completed.

Neonates The use of cefixime is not recommended

among neonates and children below
6 months.

Renal impairment Doses of cefixime should be reduced in

patients with moderate to severe renal
impairment.
Do not exceed a dose of 200mg incase
a patient has a creatinine clearance
of < 20ml/min.

Hepatic impairment Cefixime can be used in patients with hepatic

impairment without adjusting the dose.

Nathan Muyinda Busoga Health Forum

 Drug - drug interactions
Drug Interactions

Combined oral Cefixime reduces the effectiveness of

contraceptives combined oral contraceptives when
used concurrently.

BCG, typhoid and The effectiveness of BCG, typhoid or cholera

Cholera vaccine vaccine is reduced by cefixime when
used concurrently.

Gentamycin and There is increased risk of nephrotoxicity

Furosemide when cefixime is given concurrently
with gentamycin or furosemide.

Anticoagulant such Cefixime increases the anticoagulant effect

as warfarin of warfarin.

Meloxicam Cefixime increases the clinical response and

side effects of meloxicam when used
concurrently.

Nathan Muyinda Busoga Health Forum

 Food - drug interactions
• The presence of food in the stomach increases the
absorption of cefixime
• Iron-rich cereals, infant formulas decrease absorption
of cefixime.

Patient education
• Take cefixime after food in order to increase its absorption
and reduction in side effects such as nausea and vomiting.
• Take the medicine as recommended by the prescriber
and do not share your medicine with other patients.
• Advise the patient to report back to the prescriber
in case vaginal itching and discharge occurs during
treatment.
• Advise the patient to come back in case they develop
bloody diarrhoea

Nathan Muyinda Busoga Health Forum

 Brands available
Cefimed Cefix Triaxon
Gramocef Sefixi Fixinect
Sanix Cefim Ciff
Topcef Fixime Cef -3
Cebam Ixime Clinicef
Taxim-O Cefraz Oracef
Cefdia Cachmay Tixif
Cefiwel Infixime Tryfix
Virexim Fimbute

Nathan Muyinda Busoga Health Forum

PROPER USE
OF ANTIBIOTICS
SERIES

REFERENCES
Martindale 36th edition,, The complete drug reference
by sean. C. Sweetman.
Therapeutic drugs by Sir Colin Dollery.
Drug Facts and comparison 2012 edition, Wolters Kluwer.

BNF March 2022

Mosby’s Drug reference for health professionals
by Mosby publishers.
Mosby’s Drug Guide for nursing students 2018 edition
by Elsevier.
Lexi comp’s Drug reference, Paediatric dosage hand book 15th edition

Nathan Muyinda Busoga Health Forum