SGD – CASE BASED LEARNINGS:

1. A 31/M on ART treatment for AIDS complaints of painful swallowing. O/E

of his oral cavity, a whitish membrane covering much of his tongue and
palate is found.OGD Endoscopy reveals the same whitish membrane
covering esophageal mucosa.
(a) Most likely diagnosis and etiological agent responsible?
(b) Pathogenesis of the above condition
(c) Histomorphological features
(d) Other clinical conditions caused by the same etiology

2. A 45/M who had kidney transplantation three months back , now has an
one week history of fever with worsening headache. O/E : He has Nuchal
rigidity.MRI brain done and reveals soap bubble lesion and expansion of
perivascular Virchow robin spaces within the greymatter.
(a) Most likely diagnosis and etiological agent?
(b) Pathogenesis of the above condition
(c) Morphological features and name the special stains to demonstrate it?

3. 65 year old female who is a diabetic discharged from hospital after being
treated for COVID-19 pneumonia.A month after she started developing
symptoms of worsening facial and periorbital pain,with proptosis and
partial loss of vision.Her ENT Surgeon ordered CT& MRI imagings of
paranasal sinuses which shows extensive right maxillary sinusitis with
necrosis and erosion with extension to right orbital region.
(a) Most likely diagnosis and etiological agent?
(b) Pathogenesis of this condition
(c) Histomorphological features
(d) Name the closest Histopathological differential diagnosis and describe
its morphology
4. A 59/M returnee from Africa a month back presents with fever,flank pain
and hematuria. Routine blood tests reveals eosinophilia. Imaging studies
shows diffuse wall thickening and calcification of urinary bladder.
(a) Possible diagnosis of the above and etiological agent?
(b) Pathogenesis of this condition
(c) Morphological features
(d) Other species of it and their clinical presentations

5. Discuss on categories of BIO-TERRORISM agents.