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Paramedics revive an overdose

victim in the Tenderloin district of


downtown San Francisco, July 2020
THE REVERSE
OPIUM WARS
On the deadly trail of Fentanyl — from China
via Mexico to the streets and suburbs of
America, where it’s killing 200 people a day

By Stephen Gibbs in Manzanillo and Keiran Southern


in Tijuana, Los Angeles and San Francisco
I
t was a distinctive smell, similar to vinegar,
seeping from the new-built home at the
top of the hill that prompted a resident in
Tijuana’s Lomas del Valle neighbourhood
to make an anonymous call to the police
in October last year.
A few nights later three patrol cars were
seen heading up the potholed road to the
elevated dusty area, a 50-minute drive and
a world away from the souvenir stores and
tequila bars of Mexico’s main northern
Above and left: Mexican police find
more than 300,000 fentanyl pills
and drug-making equipment in a
border city. Their target was a squat, grey raid in Tijuana, October 2023
building that seemed in a permanently
stalled state of construction.
As police drew close they spotted two or guns. In the Canadian state of British
men outside, loading bags into a car. Columbia the statistics are more stark, with
Catching sight of their unwelcome visitors, unregulated drug overdoses, mostly from
the suspects bolted off into the darkness. fentanyl, the leading cause of death for all
The officers knew they had the right place people aged 10-59, according to health
and broke into the building. Inside they officials. The impact in Europe has been
found a makeshift laboratory equipped minuscule by comparison. In the European
with all the paraphernalia of synthetic drug Union about 200 people are believed to have
production. There were buckets, blenders died of fentanyl-related overdoses in 2023,
and a pill pressing machine. A thin layer of while for the past five years in the UK the
acrid white powder coated every surface. number has hovered around 60 deaths a year.
In one corner was a large icebox, the type One theory to explain why, so far, this
that might be used to take cold drinks to a seems a peculiarly US and Canada-focused
beach. It contained more than 300,000 light scourge is that both countries are seeing
blue pills of pure fentanyl. In total police the effect of decades of overprescription of
confiscated 207kg of the synthetic opiate, opioid painkillers by doctors. There were 227
enough to kill tens of millions of people, million prescriptions issued for legal opioids

FROM A BUSINESS
and with a street value of about £4 million. in the US in 2015. Even if only a tiny fraction
Fentanyl abuse is the world’s deadliest of those patients sought to continue their
drug crisis. The front line of the calamity is habit once their course ran out, that is a
just ten miles from that raided lab, over the
border in the United States. As many as 200 PERSPECTIVE, bonanza for the drug runners. British
Columbia’s experimental decriminalisation

ALMOST THE
Americans a day are dying from overdoses of the possession of hard drugs, including
of what some pushers call the “Crazy One”. fentanyl, in January 2023 has also been
The drug is most commonly taken in pill blamed for the rise in deaths there.

ONLY FLAW OF
form by abusers or injected. Some smoke it, For pushers, fentanyl has some intrinsic
which overcomes the struggle for hardened advantages over other addictive drugs.
addicts of finding a vein. Users describe Unlike cocaine and heroin, its ingredients

THE DRUG IS ITS


PREVIOUS PAGES: NICK OTTO. THIS PAGE: FGR

the “f-rush”, an out-of-body euphoria that do not have to be cultivated from coca or
lasts several hours, before the brain craves poppies: its chemical components, largely

EFFICACY IN
another hit. Each trip is a dance with death: produced in China, can be bought easily
the dose needed to produce a narcotic effect online, often legally. From a business
is just fractionally below the amount that perspective, almost the only flaw of the drug
can trigger unconsciousness, breathing
difficulties and heart failure. Many users KILLING OFF ITS is its efficacy in killing off its client base.
Politicians appear powerless to stop the

CLIENT BASE
do not survive their first hit. scourge. In 2016 Donald Trump vowed as
Last year the drug killed more Americans presidential candidate to stem “100 per cent”
aged between 18 and 49 than traffic accidents of the flow of drugs, including fentanyl, ➤

The Sunday Times Magazine • 11


into the US during his term of office. Opiate Left: Trevor Leopold
overdoses surged under his administration. with his parents,
Shocking images of zombie-like addicts Michelle and Jeff.
slumped on city streets from San Francisco He died in 2019,
to New York have prompted calls for aged 18, after
urgent action — but the death toll has taking a pill laced
remained high under President Biden, with fentanyl
who has described the crisis as an
“American tragedy”. Last year he made a Below: an evidence
series of pledges including expanded access bag of fentanyl pills
to addiction treatment and heightened disguised as the
co-operation with China to stop the chain opioid painkiller
of supply. His administration has been the oxycodone in
first to shift more resources to treatment California, 2020
than interdiction — a tacit admission that
the flow can probably never be stopped.
Some experts warn that the best hope is
that demand plateaus in a saturated market,
now the drug has penetrated every corner
of the country. “For the most part there Golden Gate Bridge from San Francisco and
aren’t any more places that are not yet hit,” The rise of a mass killer the fourth richest county in all of America.
says Jonathan Caulkins, a professor and Drug overdose deaths in the US, in thousands Living in the small community of Greenbrae,
drug policy researcher at Carnegie Mellon their beautiful home is surrounded by hills
80
University’s Heinz College in Pennsylvania. forested with oaks. The year-round sun and
In 2022 the US recorded about 109,000 Fentanyl and synthetic opioids ready access to the San Francisco Bay make
60
overdose deaths, according to the Centers Methamphetamine (and similar) the area perfect for rowers and boaters.
for Disease Control and Prevention (CDC), Cocaine Trevor Leopold, a handsome teenager
of which 70 per cent were synthetic opioids Prescription opioids 40 with blue eyes, grew to love the outdoor
including fentanyl — a slight increase on Heroin life on the doorstep of his family home.
the 2021 death toll following two years of 20 A former boy scout, he was an avid
steep rises. “I think we’re at a peak but I don’t birdwatcher able to identify almost any
see the decline from the peak happening 0 species from its call. He collected rocks
quickly,” says Caulkins, who believes the 2000 2005 2010 2015 2020 and had an encyclopaedic knowledge of
war may be unwinnable. “Fundamentally gems and minerals. “He loved learning,”
Source: National Center for Health Statistics at
dangerous drugs” such as fentanyl, he says his mother, who bears a striking
the Centers for Disease Control and Prevention
predicts, are here to stay. resemblance to her son.
In 2016 the Leopolds noticed a change
Skid Row to the Golden Gate Bridge in Trevor’s bright disposition, just as he
In the homeless areas of San Francisco and turned 15. They knew he was occasionally
Los Angeles, fentanyl users are easy to spot smoking strong cannabis. “His personality
by their stupor-like demeanour mid-hit. completely changed,” Michelle says.
More than a dozen cases can be found in “I learnt about today’s high-potency THC
a ten-minute walk around Skid Row in LA , [tetrahydrocannabinol] and realised that
where about 4,500 homeless people was what was causing this lovely, sweet,
congregate every day. One heavy-set man is caring, gentle person to become violent.”
smoking a pipe at a bus shelter and speaks Desperate to get their son back, the
only to confirm, nonchalantly, that the white Leopolds sent Trevor on wilderness retreats,
smoke he is exhaling is from fentanyl. with little success. They also booked him
Other addicts take refuge in their tattered into several rehab centres. By the time he
tents. Clutching burnt foil in swollen hands, turned 18 there were signs of improvement.
a man and a woman in their twenties are He graduated from high school and began
getting high on the drug together. They studying at Sonoma State University. But
seem not to notice the rat scurrying over just months into his degree, in November
their filthy bedding. counts fentanyl as her biggest mistake. 2019, he was dead. Trevor, his mother says,
Others in Skid Row tell stories of their “It’s the craziest thing I have ever done,” had bought four pills, believing them to be
brushes with death. Nicole Cosio, 45, she says, her hollow face a testament to prescription painkillers. One was laced with
painfully thin, with her skin drawn tightly years of drug abuse. fentanyl. Michelle, Jeff and their 21-year-old
over protruding shoulder blades, says she While these squalid scenes are the most son, Parker, now live with the grief that
overdosed some months ago and had to publicised images of fentanyl abuse, one afflicts thousands of American families.
be revived with naloxone — the antidote of the striking aspects of the drug is how
that can reverse the effects of opioids and it crosses class boundaries. Previous drug The China connection
restore breathing. She describes the whole epidemics, such as crack cocaine in the Fentanyl was first developed by the Belgian
experience as terrifying. 1980s, came to be associated with poorer physician Dr Paul Janssen in the late 1950s.
“It’s worse than heroin,” says Cosio, communities. Fentanyl finds its victims Approximately a hundred times more
who is also a crystal meth user. She says at every level of society. powerful than morphine, it was designed
her fentanyl trip left her awake for four days The Leopolds were a picture-book as an intravenous anaesthetic to alleviate
GETTY IMAGES

in a delirious paranoid state, convinced American family. Michelle, 58, and her severe pain following cardiac and vascular
that her neighbours in Skid Row were husband, Jeff, 57, run six hardware stores surgeries. It soon gained a place on the
trying to steal her disability cheques. She in Marin County, a short drive across the World Health Organisation’s list of ➤

The Sunday Times Magazine • 13


essential medicines and is still used today Left: corruption is
as a highly effective painkiller, particularly alleged to be rife
in the care of terminal cancer. at the port in
By the early 2000s reports began to Manzanillo, Mexico
emerge of illicit recreational use, with
drug addicts chewing on the slow-release Below: the
medical patches or squeezing out the gel Chinese-Mexican
inside and injecting themselves. In 2016 businessman Zhenli
millions heard the name of the drug for the Ye Gon, escorted
first time when it was revealed that the pop by Interpol agents
superstar Prince had died from an overdose. in Mexico, 2016
It has been over the past three years,
though, that illegal use has exploded. Some
experts say boredom during the pandemic
drove abuse. There has also been
speculation that China, as the main source
of the chemicals needed to produce
fentanyl, is deliberately allowing the US to
be flooded by a drug that undermines its has, what it doesn’t have, how much you have
society from within — just as Britain and to put in,” López-Serrano told the journalist
other western powers were accused of Luis Chaparro. He described how, once
doing, in reverse, during the Opium Wars his former associates began to import the
of the 19th century. precursor chemicals from China to produce
Beijing has consistently rejected this their own version of fentanyl, they realised
accusation, saying the West is seeking to they had hit the jackpot. For every dollar
blame others for its own degeneracy. invested, the criminal organisation was
Yet there can be no hiding China’s role, getting back $20. Even small-time smugglers,
willing or not, in the production of the drug López-Serrano said, were able to net “30 or
that is sometimes known on streets of Los 50 million dollars” a year.
Angeles as “China Girl”. The main reason One of the early alleged pioneers of
is a logistical one. China has the biggest the China-Mexico drug trade was the
chemical manufacturing sector in the world Fentanyl entering Shanghai-born Mexico-based businessman
the US from Mexico
— with about 45 per cent market share. Zhenli Ye Gon. In 2007 his sumptuous
If anyone, from drug cartels to legitimate Tijuana mock-château home in Mexico City was
medicine manufacturers, needs chemical raided by police. Inside they found $207
ingredients, China is a first port of call. million in cash, spilling out of cupboards.
Fentanyl sold as a recreational drug has The haul, weighing two tonnes, took
no set formula. There are several varieties, MEXICO detectives two days to count. US drug
using a combination of chemicals — as agents claimed the magnate, a colourful
many as ten — in the production process. character who once boasted he had lost
Most of the ingredients are also used to Manzanillo $126 million in Las Vegas casinos, used his
manufacture mainstream products, from legally registered pharmaceutical company
paint to pesticides. One, sodium Chemicals for as a front to provide the Mexican gangs
borohydride, is a common bleaching agent. making fentanyl with the chemicals needed to make crystal
In the early 2000s both pure fentanyl imported meth, a predecessor of fentanyl.
from China 500 miles
and the chemicals needed to manufacture “He was the one who really set up this
it would normally be shipped directly from alliance between the Mexican drug cartels,
China to the US. Intense pressure from the Mexican drug trafficking networks and
Washington to curb that trade, culminating the Chinese pharmaceutical industry,” says
in a May 2019 declaration by the Beijing provided last year by a former senior figure Ioan Grillo, author of Gangster Warlords,
government that fentanyl and two of its in the most established criminal group in an account of the drugs-driven violence
precursors would be categorised as all of Mexico: the Sinaloa cartel. in Latin America.
controlled substances, led to a sharp drop Dámaso López-Serrano, who is currently Ye Gon, who faced charges — later
in the number of seizures at US ports. co-operating with US prosecutors under dropped — in the US for importing an
The smuggling did not stop, however. It a witness protection scheme, is a godson ingredient used to produce crystal meth,
just shifted south, to Mexico. of Joaquín “El Chapo” Guzmán, the founder has always maintained he is innocent.
ALEJANDRA RAJAL FOR THE SUNDAY TIMES MAGAZINE, REUTERS

of the Sinaloa cartel and the most notorious The control of fentanyl trafficking in
The Mexican drug cartels step in drug lord alive today. El Chapo was Mexico is now dominated by what is known
Over the past 15 years synthetic drugs — extradited to the US in 2017 and is serving a as the “narco juniors”, mostly sons of the
the first was crystal meth — have begun life sentence for murder and other offences. drug lords who established their dynastic
to cut into a market long dominated by In an interview with a Mexican journalist fortunes smuggling cocaine in the 1980s
cocaine and heroin. As that business has published on the CrashOut substack site last onwards. The Guzmán family and the
grown, important cross-Pacific links have year, López-Serrano detailed how members Sinaloa cartel still play a key role in this
been formed between Mexican cartels of the Sinaloa cartel made several visits to business, despite the imprisonment of
— with their decades of experience of China over the past decade, specifically to El Chapo. Since his arrest, four of his sons,
trafficking drugs to the US — and their discover how to make fentanyl. known as the “Chapitos”, have helped steer
Chinese chemical suppliers. It has proved “We sent people who worked with us their father’s empire into the trafficking and
enormously profitable for both sides. to China and there they were introduced production of fentanyl, according to Mexican
A window into this deadly alliance was to everything, from how it is made, what it investigators and US prosecutors. ➤

The Sunday Times Magazine • 15


Griselda No one knows this better than the
Martínez, mayor of Manzanillo, Griselda Martínez.
the mayor of A petite, determined woman, as a child
Manzanillo, she dreamt of becoming a nun. She was
survived an elected mayor in 2018, having run on a
assassination promise to clean up the police force. By
attempt in 2019 then it had been heavily infiltrated by two
having vowed gangs: the Sinaloa cartel and its rival, the
to tackle police Jalisco New Generation. Martínez admits
corruption she was naive when she began her role.
Nine months after taking office she
survived an assassination attempt while
being driven through the city on a routine
trip. Her car was not armoured.
“There were 36 shots,” she says. One
grazed her slightly, while her bodyguard
was shot in the face. He survived.
After that Martínez was warned by
In 2023, in a US indictment against two intelligence officials she could never live in
of the brothers — Iván and Jesús Guzmán The interception game her home again. For the past four years she
Salazar — it was alleged that they used to Seizures of fentanyl by US Customs and has been staying, alone, in government
test the correct dosage of the fentanyl Border Protection, in lbs (thousands) buildings: a naval barracks, her city offices
they were developing by injecting it into 30 and a support centre for vulnerable women.
kidnap victims, until they overdosed. She barely sees her family. Just one of her
three children still lives in Manzanillo.
Manzanillo, gateway to China 20 At least ten guards with assault weapons
The city of Manzanillo, on Mexico’s Pacific keep watch outside during our interview.
coast, was once best known for its glorious “I really don’t have a life any more,” she says.
10
natural bay and big-game fishing, which “I breathe and I work. It is not a normal life.”
made it a go-to destination for the 1970s Martínez, 55, was born in the centre of
jet set. It was here that a bead-haired Bo 0 Manzanillo, which she remembers as a
Derek emerged from the sea in the 1979 quiet fishing backwater. “Everything we
2019 2020 2021 2022 2023
film 10, starring Dudley Moore. The money Fiscal year
wanted was right there in the sea in front
in Manzanillo now comes not from louche Source: US Customs and Border Protection
of us — crabs, shrimp, whatever we
sunlounging tourists but from trade, of all needed.” Crime, she recalls, was almost
kinds, with Asia. unheard of. “In hot weather we all slept with
Over the past half-century, mirroring the doors open, with the windows open.”
the rise of China, Manzanillo’s port has targeted; others appear to have vanished. The port, she says, has “polluted” her
grown to become the busiest in Mexico, The US also says some Chinese companies home town. “With it came all this movement
handling 3.4 million containers a year. change the composition of the chemicals of goods — and the movement of drugs.
But only a tiny fraction of those containers they export so they appear to be for They called the port progress, but progress
is ever inspected. Since 2020, after years legitimate industrial use, such as pesticides. is quality of life, not this.”
under civilian control, Mexico’s customs The businessman in Manzanillo says Anyone in law enforcement is a potential
posts have been overseen by the military. such deception is in fact unnecessary target. Martínez mentions, almost in
That change was made by President Andrés because, in his experience, a modest passing, that the second-in-command of
Manuel López Obrador in an effort to bribe paid at the port enables anything to her police force survived a murder attempt
battle corruption. Four years on, an insider, pass through. just a few days before we meet. Nizandro
speaking on condition of anonymity, By way of example, he says the tax and Gonzaga had stopped to get a haircut at a
believes the situation has deteriorated. duties on a container with $100,000 worth barber shop near his office when two armed
“Right now corruption is the worst it of goods should be about $30,000. But a men burst in and unleashed a rain of
has been in 20 years. It’s unbelievable,” $6,000 “donation” paid at the port means bullets, seriously wounding him. It was the
says the businessman, whose operation the tax bill is waived and the container second attempt on his life in months and
is based inside the port. Synthetic drug can leave without any further questions. the suspects are still at large. The barber
interdiction, he insists, is barely happening. He adds that containers set aside for shop remains closed, its glass frontage
The first problem is that most of the inspection — usually owing to a tip-off riddled with bullet holes.
precursor chemicals enter Mexico legally. regarding drugs — often disappear by dawn.
The cartels set up fake pharmaceutical “They say the cranes move alone in the Tijuana, gateway to America
companies inside the country, as Ye Gon night here,” is his wry explanation. The left-wing President López Obrador
ALEJANDRA RAJAL FOR THE SUNDAY TIMES MAGAZINE

allegedly did, and then order chemicals This conversation is held at an outdoor has made modest steps to assist the United
from China — with all the paperwork intact. café in the heart of touristy Manzanillo. States in tackling this crisis. One welcome
The US has attempted to close this Young families in beachwear browse the move last September was the extradition
loophole. In October last year the nearby street stalls as the businessman to the US of 33-year-old Ovidio Guzmán,
Department of Justice unsealed eight spells out the malignant power of El Chapo’s youngest son. He is facing
indictments against Chinese companies corruption inside the vast port. fentanyl trafficking charges.
and their employees, several of which have “You don’t get mugged in the street Yet the López Obrador government
addresses in the central city of Wuhan, on here. You can leave your car open and formally maintains the pretence that
charges of sending fentanyl precursors to nothing happens,” he says. “But when you fentanyl is not produced at any scale in
Mexico and the US. Some of the company go inside the world of drugs, everything Mexico. In March 2023 its foreign ministry
owners have said they are being falsely changes. Then you can get killed.” declared that the security services had ➤

The Sunday Times Magazine • 17


“no record” of any domestic fentanyl National guard
production at all. The US Drug Enforcement officers on a
Agency and others, however, have training exercise
evidence that hundreds of labs have been in Manzanillo. The
uncovered in Mexico. police has been
Tijuana’s mayor, Montserrat Caballero, heavily infiltrated
just like her counterpart in Manzanillo, no by drug cartels
longer lives in her home. She has moved to
an army base for protection after receiving
threats. For security reasons Mexican police
forces are largely prohibited from giving
press interviews on fentanyl-related stories.
Those who accompany The Sunday Times
in Tijuana have their faces hidden by
balaclavas and all identifying numbers
on their bulletproof vests are concealed.
Last March a police officer spotted
a man putting a bag of pills into the boot
of a Toyota Corolla with California licence

“ALMOST EVERYONE
plates in the Colinas del Sol neighbourhood, On the fringes of talks about Taiwan,
just 25 minutes from the US border. The Washington and Beijing presented
suspect attempted to escape but was a joint plan to curb the flow of fentanyl
swiftly apprehended. This led police to a
safe house that it transpired was run by the KNOWS SOMEONE into the US, with China agreeing to do
more to pursue producers of the

WHO HAS DIED OF


Sinaloa cartel. One hundred kilograms of precursor chemicals.
fentanyl and crystal meth was recovered. Biden praised Xi’s “commitment” on
One of the suspects arrested in that the issue, although when pushed on how

FENTANYL,” SAYS
operation was from the same small city much stock he could put in his counterpart’s
— Badiraguato, with a population of only promises he fell back upon a phrase
3,700 — as El Chapo himself. Ronald Reagan often used when referring
A 20-minute drive from the Tijuana
safe house are the neatly tarmacked hills of MICHELLE, A to the Soviet Union’s pledges on nuclear
disarmament during the Cold War: he said

GRIEVING MOTHER.
the exclusive Buena Vista neighbourhood. he would take a “trust, but verify” approach.
Pristine three-storey homes, which would “Fentanyl is an equal opportunity
not look out of place in Beverly Hills, murderer,” says Michelle Leopold, the
boast sweeping views of the city. A closer
look at one Dallas-style townhouse at the THIS IS NOT AN grieving mother of Trevor in San Francisco.
“It does not discriminate.”

EXAGGERATION
bottom of the hill shows it is riddled with Only briefly does her voice crack during
bullet marks, the remnants of a police our conversation — mostly she displays a
shootout with a senior cartel leader who steady stoicism. She has discovered a new
was living in the building. purpose: making sure that as few parents
Five minutes up the road, in a gated as possible have to go through what her
community, is another house A patchwork of solutions family has endured, by raising awareness
indistinguishable from the elegant The US response to the crisis has so far about the drug that killed her son.
residences alongside. Last year police raided varied across states, cities and counties. In Most weekends she can be found outside
the property and recovered 75kg of fentanyl California, where fentanyl claimed more one of her family’s hardware stores in a
in pill form, as well as 14 handguns and than 7,300 lives in 2022, prosecutors have purple T-shirt bearing the slogan “Overdose
five assault rifles. The home is six miles either begun or have announced plans to awareness”. She always carries a shot of
from the US border, the busiest road charge dealers with murder. In the state of naloxone with her and pleads with others
frontier in the world. Virginia, Loudoun County — a wealthy area to do the same. When Michelle began her
Cartels hire both Mexican and US roughly an hour west of Washington — has mission in 2019, she says hardly anyone
citizens to smuggle the easily concealed announced plans to sweep high schools listened. Now, after hundreds of thousands
pills across the border. Most of the with sniffer dogs to combat rising overdose of deaths, parents are waking up to the
fentanyl in the US is believed to arrive deaths among teenagers. danger. Michelle’s meetings are packed.
via legal entry points. The potency and At the federal level, last year the Food “Almost everybody knows somebody”
concentration of the drug means just three and Drug Administration approved who has died from fentanyl, she says. The
lorryloads would be enough to supply the over-the-counter sales of the overdose statistics show that is not the exaggeration
entire US market for a year. The going rate reversal drug naloxone, a move that it might seem: four out of ten Americans in
ALEJANDRA RAJAL FOR THE SUNDAY TIMES MAGAZINE

for a courier, or “mule”, travelling by foot proponents of the so-called “harm-reduction one recent survey said they knew someone
and taking 1,000 pills is about $500 per model” have demanded for years. who had died from a drugs overdose.
crossing. Cartels recruit many of the Supporters of the decision say that putting Michelle believes that the US government
young carriers via social media, with naloxone kits in as many hands as possible still isn’t doing enough to inform Americans
discreet job opportunity adverts. will save lives. New York state has also of the risks posed by fentanyl. That task,
Amid heightened checks on the US made naloxone available free from she says, has fallen into the hands of an
side there has been a recent surge in the vending machines. “army” of devastated families. “The
number of “body carriers” caught at the Those calling for international action education is coming from parents with
border — those who conceal the pills in have been encouraged by discussions first-hand experiences,” she says. “We just
packets that are often stuffed into their between presidents Biden and Xi Jinping at don’t want anybody else to join this horrific
rectal or vaginal cavities. a summit held in California last November. club of having to bury your own child.” n

The Sunday Times Magazine • 19

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