DROP NOTES | Everyone Pharma

SWEETENING AGENTS USED IN PHARMACEUTICAL

FORMULATIONS

Sweetening Composition &

S.no Special points
agent Structure

It is 200 times more sweet

Made from than sugar but calorie
Acetoacetic acid content is negligible.
Acesulfame-
It has a slightly bitter
1. Potassium
aftertaste.
(Ace K)
Unlike aspartame,
acesulfame K is stable
under heat, allowing it in
products that require a long
shelf life.

Made from Aspartic

It is 200 times more sweet
acid and Phenyl
than sugar. Calorie content
alanine, both are
is 4 kcal per gram.
amino acids.
(Aspartame is the Under strongly acidic or
methyl ester of a alkaline conditions,
Phenylalanine / aspartame may generate
2. Aspartame Aspartic acid methanol by hydrolysis.
dipeptide)
Aspartame is immediately
metabolized to
Phenylalanine, Aspartic acid
and Methanol.

Aspartame is NOT suitable

for people with phenyl
ketonuria.

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Made from
Anthranilic acid It is 300 times sweeter than
sugar. Calorie content is nil.

Saccharin An artificial sweetener, but

3 has an unpleasant bitter or
(Benzoic sulfimide)
metallic aftertaste,
especially at high
concentrations.

Sucralose is approximately
600 times as sweet as
sucrose (table sugar), twice
4 Sucralose as sweet as saccharin, and
3.3 times as sweet as
aspartame.

Calorie content is nil.

Organochlorine
artificial sweetener

30–50 times sweeter than

sugar.

It is less expensive than most

Sodium cyclohexyl sweeteners and is stable under
sulfamate heating.

The ratio of cyclamate :

saccharin mixture 10:1 is
5 Sodium cyclamate found to increase the
incidence of bladder cancer in
rats.

Its sale is banned in the

United States. However,
Cyclamate is approved as a
sweetener in over 55
countries.

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It occurs naturally in fruits

A natural sugar and fermented foods.
alcohol
It is 60–70% as sweet as
table sugar yet it is almost
non-caloric, does not affect
6. Erythritol blood sugar, does not cause
tooth decay.

In the body, erythritol is

absorbed, and then for the
most part excreted
unchanged in the urine.

Found in the fibre of many

Pentose (Alditol)
fruits and vegetables.

Xylitol is roughly as sweet

as sucrose with only two-
7. Xylitol thirds the food energy.

Xylitol is a safe sweetener

for people with diabetes
that would not impact
insulin levels.

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