AVIPRO® THYMOVAC

The live-attenuation, freeze-dried,

via drinking water applied
CAV Vaccine

PM-VN-22-0314
1
01/2022/XNQC-TY
VACCINATION AGAINST
CHICKEN ANEMIA VIRUS
• Current vaccine strategies are based on the prevention of vertical and horizontal
transmission of CAV to very young chicks by immunization of breeders.

• Effective vaccination against CAV decreases the risk of reduced performance and health of
chicken progenies

© 2021 Elanco or its affiliates 2

PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
Product characteristics
• For protection of the vaccinated breeder against excretion and transmission of CAV to eggs.

• For passive protection conferred to the progeny against clinical signs and lesions of CAV.

• The protection of the progeny is ensured for up to 43 weeks after vaccination, and chicks are
protected at one day old

Summary of Product Characteristics AviPro® Thymovac (1824). REF-01824,

© 2021 Elanco or its affiliates 3
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
Product characteristics
• Live lyophilisate vaccine against CAV infection - low-attenuation Cux-1 strain.

• Easy administration by drinking water.

• Administration in breeders from 8 weeks of age onwards, but no later than 6 weeks before
the onset of lay

Summary of Product Characteristics AviPro® Thymovac (1824). REF-01824,

© 2021 Elanco or its affiliates 4
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
Key benefits

» Higher & more homogeneous humoral response than other CAV vaccines

» Higher level of maternal immunity than other CAV vaccines

» Easier administration than injectable CAV vaccines

© 2021 Elanco or its affiliates 5

PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High & more homogenous humoral response
• High antibody responses are the major arm of protective immunity against CAV infection -
Higher & more homogeneous and long-lasting humoral response than other CAV
vaccines

• High and homogeneous CAV antibody titers are needed throughout the entire breeder’s
production life cycle - Higher level of maternal immunity than other CAV vaccines

• AviPro® Thymovac induces higher and more homogeneous antibody - Easier administration
than injectable CAV vaccines response in breeder hens

Summary of Product Characteristics AviPro® Thymovac (1824). REF-01824,

© 2021 Elanco or its affiliates 6
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High & more homogenous humoral response

» Greater serological response was observed

in the broiler breeder group vaccinated
with AviPro® Thymovac at 3 and 6 weeks
post-vaccination (pv).5

Comparative study of three different CAV vaccines in Thailand. Niwat Chansiripornchai, Avian Health
Research Unit, Faculty of Veterinary Science, Chulalongkorn University, Thailand. WVPAC 2013 REF-09197
© 2021 Elanco or its affiliates 7
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC Live-attenuated, freeze-dried vaccine

High & more homogenous humoral response

» More homogeneous serological response was

observed in the broiler breeder group vaccinated
with AviPro® Thymovac at 6 weeks pv.

» As evaluated by Vaccination Index (VI),

AviPro® Thymovac induced the highest humoral
response.5

Comparative study of three different CAV vaccines in Thailand. Niwat Chansiripornchai, Avian Health Research Unit,
Faculty of Veterinary Science, Chulalongkorn University, Thailand. WVPAC 2013 REF-09197
© 2021 Elanco or its affiliates 8
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High & long lasting humoral response
LONG-LASTING HUMORAL RESPONSE

» AviPro® Thymovac induces long-lasting

and high CAV antibody titers during the entire
production period.

» Flocks vaccinated with another CAV vaccine

administered via injection displayed decreasing
titers.4

CHICKEN ANEMIA VIRUS (CAV) SEROLOGY PROFILE OF BREEDERS AND THEIR PROGENY- REF-01837
© 2021 Elanco or its affiliates 9
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High & more homogenous humoral response
9 wks before vaccination

Uniform response

10 wks after vaccination

The impact of CAV vaccination with TAD

© 2021 Elanco or its affiliates
Thymovac on T-cell function. REF-05014 10
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High & more homogenous humoral response
13 wks before vaccination

Uniform response

10 wks after vaccination

The impact of CAV vaccination with TAD Thymovac on T-

cell function. REF-05014
© 2021 Elanco or its affiliates 11
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High level of maternal antibody
» Humoral antibody response, including passively acquired maternal
antibody, is highly protective against CAV infection, replication and disease.

» Maternal antibodies must be as high as possible for effective protection

against CAV.

» AviPro® Thymovac induces high maternal antibody level in progeny

chickens.

CHICKEN ANEMIA VIRUS (CAV) SEROLOGY PROFILE OF BREEDERS AND THEIR PROGENY- REF-01837
© 2021 Elanco or its affiliates 12
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High level of maternal antibody
CAV maternal antibody titers

6,844 » The progeny from breeder flocks vaccinated

MT with AviPro® Thymovac showed higher
maternal antibody titers (first day of age)
3,577
compared to the progeny from flocks
vaccinated with another CAV vaccine
administered via injection. 4
Progeny from birds vaccinated with AviPro® Thymovac
Progeny from birds immunized with another CAV vaccine

CHICKEN ANEMIA VIRUS (CAV) SEROLOGY PROFILE OF BREEDERS AND THEIR PROGENY- REF-01837
© 2021 Elanco or its affiliates 13
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High level of maternal antibody
100% 100% 100%
» The offspring from parent stock vaccinated
with AviPro® Thymovac and challenged with
CAV did not show any clinical signs or lesions
and presented a normal hematocrit value
35%
indicating complete and effective protection
24% against CAV.
0% 0% 0%
» The high level of maternal antibody titers
BONE
MARROW
THYMUS
LESIONS
CLINICAL
SYMPTOMS
HEMATOCRIT
provides an effective protection against CAV.9
LESIONS

Progeny from 56-week-old birds immunized with AviPro® Thymovac

Progeny from unvaccinated birds

CHICKEN ANEMIA VIRUS (CAV) SEROLOGY PROFILE OF BREEDERS AND THEIR PROGENY- REF-01837
© 2021 Elanco or its affiliates
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
High level of maternal antibody
Lesions at 2 weeks after CAV + IBDV challenge
» The progeny from birds immunized with
3 3 AviPro® Thymovac and challenged with CAV
and IBDV showed slight lesions in the thymus
and bone marrow compared to the severe
lesions in the control group.
1.1
0.8 » Lower impact of CAV + IBDV co-infection is
observed due to the high level of maternal
antibody titers.10
BONE THYMUS
MARROW LESIONS
LESIONS

Progeny from birds immunized with AviPro® Thymovac

Progeny from unvaccinated birds

CHICKEN ANEMIA VIRUS (CAV) SEROLOGY PROFILE OF BREEDERS AND THEIR PROGENY- REF-01837
© 2021 Elanco or its affiliates
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
Easier administration

» AviPro® Thymovac is easy to administer because can be delivered via

drinking water.3,7,8

» Injectable CAV vaccines require labour-intensive vaccination as they are

administered via parenteral (wing web, intramuscular or subcutaneous
injection).7,8

The use of vaccination in poultry production. S. Marangon & L. Busani. Rev. sci. tech. Off. int. Epiz., 2006, 26 (1), 265-274.
Drinking Water Vaccination: Easy and Effective. Technical Bulletin. Bernardi E, and Johnson S. 2011 (1931).
© 2021 Elanco or its affiliates 16
PM-VN-22-0314 01/2022/XNQC-TY
 ®
AVIPRO THYMOVAC
Easier administration
Injectable CAV AviPro® Thymovac
vaccines DRINKING
PARENTERAL WATER

Demanding process Easy process

Individual injection No need to inject any bird
Individual bird handling Absence of bird handling
Stress of the birds Minimal stress
Labour-intensive Labour-saving
Increase labour cost Save labour cost
Possible tissue damage No tissue damage
Specialized equipment Little specialized equipment
Risk of birds missing vaccination11 Improve flock immune coverage5

The use of vaccination in poultry production. S. Marangon & L. Busani. Rev. sci. tech. Off. int. Epiz., 2006, 26 (1), 265-274.
Drinking Water Vaccination: Easy and Effective. Technical Bulletin. Bernardi E, and Johnson S. 2011 (1931).
© 2021 Elanco or its affiliates PM-VN-21-0330
PM-VN-22-0314 01/2022/XNQC-TY
08/2021/XNQC-
 ®
AVIPRO THYMOVAC
Take Away
• Higher & more homogeneous humoral response than other CAV vaccines

• Higher level of maternal immunity than other CAV vaccines

• Easier administration than injectable CAV vaccine response in breeder hens

© 2021 Elanco or its affiliates 18

PM-VN-22-0314 01/2022/XNQC-TY
 REFERENCES
1.Summary of Product Characteristics AviPro® Thymovac (1824). REF-01824
2.Chicken Anemia Virus (CAV) serology profile of breeders and their progeny. B. Cardoso et al. WVPAC-2013. (1837) REF-01837
3.Field study of seroconversion of three different commercial vaccines of chicken infectious anemia virus in Thailand .
Chansiripornchai. Faculty of Vet. Science, Thailand. Thai J Vet Med. 2016. 46(4): 699-704. (9197). REF-09197
4.Drinking Water Vaccination: Easy and Effective. Technical Bulletin. Bernardi E, and Johnson S. 2011 (1931). REF-01931
5.Study LAH--2004 Report C.7 2004 (v1.0) — The impact of CAV vaccination with TAD Thymovac on T-cell function. REF-05014
6.Study Trial 555 04 2007 (v2.0)— Efficacy Trial AviPro Thymovac. REF-03729
7.The use of vaccination in poultry production. S. Marangon & L. Busani. Rev. sci. tech. Off. int. Epiz., 2006,
26 (1), 265-274.
8.Drinking Water Vaccination: Easy and Effective. Technical Bulletin. Bernardi E, and Johnson S. 2011 (1931).

© 2021 Elanco or its affiliates 19

PM-VN-22-0314 01/2022/XNQC-TY
 Live-attenuated, freeze-dried,
via drinking water applied
CAV vaccine

FEELING
THE POWER
A v iP r o , E la nc o a nd t he d ia g o na l b a r a r e t r a d e m a r k s o f E la nc o
o r it s a f f ilia t e s . © 2 0 2 0 E la nc o . PM-GLB-MAR-20-0636

AviPro® Thymovac: Live vaccine (freeze-dried) for poultry against Chicken Infectious Anaemia. For oral administration via the drinking
water. Composition: 1 dose contains min. 104.5 TCID50 CIA virus, strain Cux-1. Indications: Active immunisation of breeder pullets and
passive immunisation of their progeny against Chicken Infectious Anaemia. Contraindications: Do not vaccinate clinically ill or
weakened birds. Do not vaccinate before 8 weeks of age and not later than 6 weeks before the point of lay. Side effects: Not known.
Interactions with other products: Not known. Directions for use: Administer 1 dose per bird. Withdrawal: 0 days. For veterinary use only.
Storage: Keep at + 5°C ± 3°C. Do not freeze. Protect from sunlight.
© 2021 Elanco or its affiliates