J. Clin. Med.

2023, 12, 6711 5 of 17

Table 1. Stent platform characteristics.
Synergy Xience Ultimaster Coroflex® Isar Biofreedom
Stent Platform Synergy XD™ Orsiro® Mission Resolute Onyx™ Biomatrix Alpha
Megatron™ Skypoint™ Nagomi™ Neo Ultra™
platinum– platinum–
Metal alloy cobalt–chromium cobalt–chromium cobalt–chromium cobalt–chromium cobalt–chromium cobalt–chromium cobalt–chromium
chromium chromium
Sirolimus
Active drug everolimus everolimus everolimus sirolimus zotarolimus biolimus A9 sirolimus biolimus A9
/probucol
Ø 2.25–2.75: 74 µm
Ø  3.0: 60 µm Ø  3.0: 55 µm Ø  3.0: 84 µm
Strut thickness Ø 3.0–3.5: 79 µm 89 µm 81 µm 81 µm 83 µm 80 µm
Ø 3.5: 80 µm Ø 3.5: 65 µm Ø 3.5: 88 µm
Ø 4.0–5.0: 81 µm
Polymer Fluorinated
PLGA PLGA Poly-L-lactic Acid BioLinx™ Polylactic Acid PDLLA na na
composition Copolymer
Polymer type Biodegradable Biodegradable Durable Biodegradable Durable Biodegradable Biodegradable No polymer No polymer
3.5 µm (abluminal)
Polymer thickness 4 µm 4 µm 7.8 µm 5.6 µm 8–11 µm 15 µm na na
7.4 µm (rest)
Polymer
4 months 4 months na 12–24 months na 6–9 months 3–4 months na na
degradation delay
Coating Abluminal Abluminal Circumferential Circumferential Circumferential Abluminal Abluminal Abluminal Abluminal
Ø 2.25–2.5: 3.5
ØJ.x2.25–2.75:
J. Clin. Med. 2023, 12, Clin. Med.3.5
FOR PEER 2023,
REVIEW12, x J.
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2023, 12, x FOR 2023, 12, x J.FOR
Med.REVIEW
PEER Clin.PEER
Med. REVIEW
2023, 12, x FOR mmPEER
J. Clin. Med.REVIEW
2023, 12, x J.FOR
Clin.PEER 2023, 12,Øx 
Med.REVIEW J. 2.5:
FOR Clin.3.5
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Med.
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Stent expansion mm Ø  3.0: 3.75 mm Ø  3.0: 3.5 mm Ø 2.75–3.0: 4.0 Ø  3.0: 3.5 mm Ø 2.75–3.0:
5 of 12 4.5 Ø 63.0:
of 3.5
12 mm Ø  3.0:
7 of4.76
12 mm 8 of 12
Ø 3.5: 6.0 mm 3 of 12 4 of 12
capacity Ø 3.0–3.5: 4.25 mm Ø 3.5: 5.75 mm Ø 3.5: 4.5 mm mm Ø 3.5: 4.5 mm mm Ø 3.5: 4.5 mm Ø 3.5: 5.95 mm
Ø 4.0: 5.75 mm Ø 3.5–4.0: 5.0 mm Ø 3.5: 6.25 mm
Ø 4.5–5.0: 6.0 mm
Radiopaque
Marker position
Ø: diameter, PLGA: poly(D,L-lactide-coglycolide), PDLLA: poly(D,L-lactide-co-caprolactone), na: not adapted.
 J. Clin. Med. 2023, 12, x FOR PEER REVIEW
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Figure 2. Stent thickness

Figure 2. Stent thickness.

Xience Skypoint Biomatrix alpha Synergy XD

3-connector design 3-connector design 2-connector design

In Phase Peak-to-Valley Out-of-phase Peak-to-Peak Off-set Peak-to-Peak

Stent on marker Stent inside marker

Ultimaster Nagomi

Resolute Onyx

2-connector design
Orsiro Mission Off-set Peak-to-Peak

2-connector design
Cofoflex IsarNeo Out-of-phase Peak-to-Peak

3-connector design
Mid-strut

3-connector design
Mid-strut

Figure 3. Stent structure and distance from balloon marker.