ABSTRACT

ABSTRACT
Objective: Atorvastatin calcium exhibits poor bioavailability due to its low water solubility

and extensive first-pass metabolism. By formulating Atorvastatin calcium as a nanogel enhance

the solubility, leading to improved drug absorption and bioavailability. Enhance wound healing

efficacy, provide controlled drug release and offer localized delivery, ultimately improving

patient outcomes in the treatment of wounds.

Methods: Atorvastatin calcium nanocrystals (NCs) were prepared by 23 factorial design and
solvent antisolvent precipitation method. The influences of three formulation excipients such as

stabilizer (Pluronic F-127), solvent antisolvent ration and stirring time on the characterization of

NCs were investigated. Aloe vera-carbopol gel was added to the chosen F8 nanosuspension

formulation, and the mixture was stirred at 800 rpm in a magnetic stirrer to create Nanogel (NG).

The prepared ATC NG was evaluated for their Transparency, smoothness and relative density,

pH, moisture content, rheological behavior, spreadability, drug stability and permeability tests in

an ex vivo model.

Results: Compared to the pure drug, the improved formulation NCs exhibited much higher

saturation solubility and a much faster dissolving rate. The ATC loaded aloe-carbopol gel (AG)

and ATC nanoparticle loaded gel (ANG) is clear and viscous. The pH was found to be 6.5 which

is nearly neutral and it does not cause any tingling or irritation when applied on the skin. The

dynamic viscosity of the ANG is found to be 8500 cp which shows the thickness of the gel and it

will stays in the place where it will be applied. Based on the results of drug permeation

investigations performed in an ex vivo on AG showed a release of 50±8 µg/cm 2 at the end of 24

hours whereas the ANG showed a release of 400±18 µg/cm2. The results of the stability tests

showed that there were no detectable changes in the product after storage for up to 90 days.

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 ABSTRACT

Conclusion: This study shows that the formulation of ATC based Nanogel have sustain

release activity and may be useful in solving the limitations of conventional drug delivery

system. Patient compliance will be more because topical administration of these Nanogel is less

greasy, transparent and comfortably applied on the skin.

Keywords: Atorvastatin Calcium, Nanocrystals, Solvent Antisolvent Precipitation Method and

Nanogel.

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