Leila Jamali

• Shahrak Gharb • Tehran, Iran • leilajam28056@gmail.com • +98 (912) 495 6764 • Scholar.google.com

Research Interests

✓ Molecular Oncology
✓ Investigation about role of autophagy pathway in cancer development
✓ Gene Mapping and High-throuput Sequencing.
✓ Carrier detection
✓ Bioinformatics tools to sequence and analyze the genomes

Education

PhD in Medical Genetics - Shahid Beheshti University of Medical Sciences

Thesis Title: Expression analysis of DAXX, SPOP, RARRES1, and LAMP2 from
autophagy pathway and related miRNAs ( hsa-miR-5582, hsa-miR-302d, hsa-miR-567, Sept 2015 – Jan 2019
hsa-miR-365a-3p) in tissue and plasma of patients with prostate cancer compare with
control to determine the potential biomarker of prostate cancer.

M. Sc. in Human Genetics - University of Social Welfare and Rehabilitation Sciences

Thesis Title: Carrier detection of 69 known genes involve in cancer in a healthy person Sept 2012– Des 2014
with a history of familial cancer, using whole exome sequencing strategy.

B. Sc. in Medical Laboratory Sciences - Islamic Azad University, Tehran Medical

Branch Sept 2008 – Sept 2011

Publications

1. Kimia Kahrizi, Niloofar Bazazzadegan, Leila Jamali, Nooshin Nikzat, Atie Kashef, H.Hilger
Ropers, Hossein Najmabadi (2014). A novel mutation of the USH2C (GPR98) gene in an Iranian
family with Usher Syndrome Type II (2014). Journal of genetics. (IF= 1.508). DOI:10.1007/s12041-
014-0443-3

2. Christina M Sloan-Heggen, Mojgan Babanejad, Maryam Beheshtian, Allen C Simpson, Kevin T

Booth, Fariba Ardalani, Kathy L Frees, Marzieh Mohseni, Reza Mozafari, Zohreh Mehrjoo, Leila
Jamali, Saeideh Vaziri, Tara Akhtarkhavari, Niloofar Bazazzadegan, Nooshin Nikzat, Sanaz Arzhangi,
Farahnaz Sabbagh, Hasan Otukesh, Seyed Morteza Seifati, Hossein Khodaei, Maryam Taghdiri, Nicole
C Meyer, Ahmad Daneshi, Mohammad Farhadi, Kimia Kahrizi, Richard JH Smith, Hela Azaiez,

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Hossein Najmabadi (2015). Characterising the spectrum of autosomal recessive hereditary hearing
loss in Iran. Journal of medical genetics.(IF=5.327). DOI: 10.1136/jmedgenet-2015-103389

3. Leila Jamali, Mohammad Mehdi Banoei, Elham Khalili, Sepideh Dadgar, Massoud Houshmand
(2016). Association of genetic variations in the mitochondrial D-loop with β-thalassemia.
Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis.(IF=1.442). DOI:
10.3109/19401736.2014.958730

4. Leila Jamali, Roghayeh Tofigh, Sara Tutunchi, Ghodratollah Panahi, Fatemeh Borhani, Saeedeh
Akhavan, Parisa Nourmohammadi, Sayyed MH Ghaderian, Milad Rasouli, Hamed Mirzaei (2018).
Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal
cancers. Journal of cellular physiology.(IF=6.644). DOI: 10.1002/jcp.26850

5. Leila Jamali, Afshin Moradi, Maziar Ganji, Mohsen Ayati, Behrang Kazeminezhad, Zahra Fazeli
Attar, Hamid Ghaedi,
Seyyed Mohammad Hossein Ghaderian, Morteza Fallah-Karkan, Arash Ranjbar (2019). Potential
Prognostic Role for SPOP, DAXX, RARRES1, and LAMP2 as an Autophagy
Related Genes in Prostate Cancer. Urology journal .(IF=1.072). DOI: 10.22037/uj.v0i0.4935

6. Leila Jamali, Hossein Sadeghi, Mohammad‐Reza Ghasemi, Roohollah Mohseni, Ehsan

Nazemalhosseini‐Mojarad, Vahid Reza Yassaee, Pegah Larki, Mohammad Reza Zali, Reza
Mirfakhraie (2022). Autophagy ATG16L1 rs2241880 impacts the colorectal cancer risk: A
case‐control study. Journal of Clinical Laboratory Analysis.(IF= 2.906). DOI: 10.1002/jcla.24169

Conference Presentation

POSTER PRESENTATION

1. Leila.Jamali, et al. Carrier detection of 487 known genes involve in cancer in 24-26 May 2014
a healthy person with a history of familial cancer, using whole exome sequencing
strategy. (Poster presentation). 1th international and 13th annual Iranian Genetics
Congress, Tehran, Iran.

2. Tara Akhtarkhavari, Leila.Jamali, et al. Whole Exome Sequencing of the 24-26 May 2014
oldest guy in Iran, (Poster presentation), 1th international and 13th annual Iranian
Genetics Congress, Tehran, Iran.

Experience

Research Experience:
• Linkage analysis of DFNB2 locus in 36 affected family with Jan 2016 -May 2016
nonsyndromic hearing loss. University of social Welfare and
Rehabilitation Sciences, Medical Genetics group. Tehran, Iran.

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 Skills learned:

✓ Linkage analysis (Indirect method)

✓ Polyacrylamide gel electrophoresis
✓ Sanger sequencing

Professional Experiences:
• Technical Director of Medical Genetics Laboratory, Laleh Hospital Tehran, Iran. Sept 2019- July 2021
• Technical Director of Aroshagene Medical Genetics Laboratory, Tehran, Iran. Jul 2021 - Oct 2022
• Technical Director of Cytogenetics Gene Medical Genetics Laboratory, Tehran, Iran. Oct 2021 up to now
• Technical Director of ARTA Medical Genetics Laboratory, Tehran, Iran. Feb 2023 up to now

Skills

Skills learned:
✓ Genetic counseling and pedigree analysis,
✓ Annotation and analysis of NGS results,
✓ Interpretation of molecular test results,
✓ Bioinformatics and computer based sequence analysis,
✓ Sanger sequencing data analysis,
✓ DNA extraction (Both Commercial and salting out method),
✓ RNA extraction, (Both Commercial and Trizol method),
✓ Tetra ARMS PCR,
✓ primer designing,
✓ Real-time PCR,
✓ Linkage analysis,
✓ QF-PCR
✓ Cytogenetic ( Blood, AF, Bone Marrow Karyotype)
✓ Diagnostic tests and techniques in Mutation Detection and results annotation

Technical Skills:

• Medical Genetics Techniques: Performing molecular genetic tests mostly in field of

Clinical Genetic laboratory and infertility such as PND, PGD, qfPCR, Cancer genetics
and nucleotides expansion diseases, Data analyzing of WES. Bioinformatics and
computer based sequence analysis

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Teaching Experience:

• Teaching Assistant: Islamic Azad University, Tehran Medical Science, Feb 2020 – Jul 2021
Tehran, Iran

Honors, Awards and Grants

✓ 2015:1st rank in 2015-2016 Medical Genetics PhD Comprehensive exam of Shahid Beheshti
University Medical Sciences
✓ 2011:1st rank with honor-MSc at University of Social welfare and Rehabilitation
Sciences
✓ 2007: Islamic Azad University Of Tehran Medical Sciences talented and gifted students

Languages

Farsi (Native), English (Fluent)

References:

✓ Dr.Hossein Najmabadi: Professor of Genetics, University of Social Welfare and

Rehabilitation. Email. Ho.najmabadi@uswr.ac.ir

✓ Dr.Kimia Kahrizi: Professor of Genetics, University of Social Welfare and Rehabilitation.

Email. k.kahrizi@uswr.ac.ir

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