Tutorial questions – Chapter 34

Control of Eukaryotic gene expression

1. Describe how the preinitiation complex is formed during eukaryotic transcription initiation.
2. Why is the TATA-box binding protein (TBP) seen as a universal transcription factor?
3. Explain the two models that propose how the RNA polymerase transcribes through the nucleosome.
4. What is the “histone code”?
5. Explain how and why chromatin remodeling is necessary for efficient gene expression.