Professional Documents
Culture Documents
Injury
j o u r n a l h o m e p a g e : w w w. e l s ev i e r. c o m / l o c a t e / i n j u r y
David Seligson*
Chief of Orthopedics, University of Louisville Hospital, Louisville, KY, United States
KEYWORDS ABSTRACT
History Dr. Raoul Hoffmann of Geneva, Switzerland with the collaboration of Henri Jaquet developed the
External fixation original Hoffmann external fixateur as a system for treating broken bones without necessarily opening
Hoffmann a fracture site to reposition the bone ends. This system has evolved to a more flexible, modular concept
with input from surgeons and engineers. In this chapter the modifications of the Hoffmann family of
fixators are traced and the important steps in the development of the concept and the instrumentation
emphasized.
© 2015 Elsevier Ltd. All rights reserved.
Hoffmann original to show at the meeting. By morning all that was left was the
external fixator as his dog had finished off the bone.
In his youth, Raoul Hoffmann worked with his brother as an The thrust of Hoffmann’s report to the Swiss Surgical Society
apprentice carpenter in the Place de Bourg-de-Four in the old in 1938 was the invention of a fixator for controlled reduction
section of Geneva. Hoffmann had qualifications in theology and of fractures with a closed (in contrast to an open) technique.
medicine from the University of Geneva and was a line officer Raoul Hoffmann applied for a Swiss Patent on 6 April 1938. The
(not a medical officer) in the Swiss Alpine patrol where, being a Patent for his «Fixateur pour le traitement des fractures des
Swiss citizen, he reported periodically for obligatory duty. When os» was awarded on 15 March 1939. This was a difficult time
he set up practice in general surgery in the Village of Tramelan that coincided with the rise of National Socialism in Germany.
in the Jura, Hoffmann doubtless treated ski fractures of the tibia. Switzerland remained neutral with a closely controlled border
By the 1930s external skeletal fixation was an established, if with Germany. Hoffmann broke his leg in an accident and
special, technique. Fixators were linear constructs. The fracture apparently continued to bicycle to work in an external fixator
site was opened, the bone repositioned, a fixator applied and the until the tibia healed [2]. Custom devices were manufactured for
skin closed. Skin wounds, particularly wounds over subcutaneous Hoffmann (Figure 1, the Hoffmann ‘key’). Ullrich in nearby Ulm,
bones, can be problematic. Raoul Hoffmann, who moved back to Germany, refused to make the clamps because he thought that
Geneva with his private surgical practice because the government the market for them would be too small [1,3]. In 1947 a shop
built a road through his house, became interested in solving the was set up in Geneva by the new engineering graduates Henri
problem of fracture reposition without opening the fracture site. and Georges Jaquet for the manufacture of medical devices that
Hoffmann was a gentleman, a tennis player and also a religious required ‘mechanics and/or electronics.’ In 1948 Jaquet Frères
thinker. He had a famous ironic smile. began to make Hoffmann Fixators with an improved design
Hoffmann was concerned about the problems of infection using two plates and a wing nut to give more secure fixation of
at the bone-pin junction. Parkhill and Lambotte had surface the pin holding the clamp to the connecting rod. The original
treated their pins to prevent skin reactions. Hoffmann conducted components were fabricated in stainless steel with a grooved
research in rabbits. Finally he found a manufacturer in Biel who Bakelite surface to hold the pins (Figure 2). The pins were
could make a tempered stainless steel pin that was sharp enough manufactured in tempered stainless steel. Parts were made one-
to penetrate bone without causing too much heat [1]. The story at-a-time on machine-lathes and finished and controlled by
is told that on the night before his presentation of his fixator hand. The basic components were ball-joints, rods, a hand brace
to the Surgical Society, he obtained a bone from the pathology for inserting the pins, guides and a skin lance [1]. Hoffmann’s
department, made a fracture and mounted a fixator on the bone essential innovation was the bone handle, in French rotule. The
concept was to create a solid anchorage in bone by placing two
or three pins along the axis of the bone and fixing these pins in
* Corresponding author at: Chief of Orthopedics, University of Louisville
Hospital, 530 South Jackson Street, Louisville, Kentucky 40202 USA. a pin-holding clamp. One grip was proximal and one was distal
E-mail address: david.seligson@louisville.edu (D. Seligson). to the fracture to enable manipulation of the bone for fracture
0020-1383/$ – see front matter © 2014 Elsevier Ltd. All rights reserved.
Downloaded for Anonymous User (n/a) at CK Mobile App Test from ClinicalKey.com by Elsevier on April 21, 2024.
For personal use only. No other uses without permission. Copyright ©2024. Elsevier Inc. All rights reserved.
S4 D. Seligson / Injury, Int. J. Care Injured 46 S3 (2015) S3–S6
Fig. 1. The ‘key’ from Hoffmann’s early fixator – much like the key to a church gate.
Courtesy Dr. Anne-Christine Hoffmann and Dr. Richard Stern, University Hospital,
Geneva, Switzerland. Fig. 3. The Vidal-Adrey frame provided great rigidity at a fracture site. Courtesy
Mitchell Orthopedics Supply, Louisville, Kentucky.
Downloaded for Anonymous User (n/a) at CK Mobile App Test from ClinicalKey.com by Elsevier on April 21, 2024.
For personal use only. No other uses without permission. Copyright ©2024. Elsevier Inc. All rights reserved.
D. Seligson et al. / Injury, Int. J. Care Injured 46 S3 (2015) S3–S6 S5
Fig. 4. The Hoffmann II in a multiply injured patient. The frame permits modular whether or not the new designs are safe and effective, attractive
construction by allowing the addition of bars, pins and clamps, as needed.
and potentially useful.
An early idea (2008) from the new Hoffmann plant was a
Oganesyan fixator. Howmedica introduced the Monotube, the disposable, MRI-safe frame for orthopaedic trauma. This fixator
Monticelli-Spinelli ring frame, the Tenxor and a Dynamic Joint made of polymers was modular, had large 15 mm diameter
distractor combining these frame concepts with the fixation pins aluminium connecting bars, and could not be reused because it
and clamps of the original Hoffmann and the Hoffmann II. In was supplied in sterile packaging and would melt if autoclaved.
most clinics, Hoffmann II frames were less in use as a device for As the agenda for an entirely new system evolved, this ‘Hoffmann
the treatment of closed uncomplicated fractures than they were Xpress’ was not widely marketed or supplied.
devices to be brought out for the complicated open fracture or The earthquake on 12 January 2010 in Port-au-Prince, Haiti
for use in the combat zone. In an attempt to satisfy the combat created a catastrophic number of patients with unstable skeletal
need, Howmedica developed a sterile-packed disposable frame injuries. Temporary external skeletal fixation as originally
for use by the military (the Ultra-X). This project was abandoned proposed by Hoffmann was used widely in this theatre for
when the frame did not pass tests for uses for which it was not ‘damage control.’ The morning after the quake, the Israel Defence
intended [10]. Force set up a hospital. The Israelis and others used a large
tube (11 mm) sterile packaged external fixator for earthquake
Hoffmann 3 – Selzach causalities [12]. Although external fixation was widely applied
by various national groups following the disaster in Haiti, there
On December 4, 1998, the Stryker Corporation of Kalamazoo, was no systematic plan for definitive skeletal repair after the
Michigan, acquired Howmedica, the owner of Jaquet Orthopédie, initial damage control application of external fixation. Many of
which manufactured the Hoffmann II fixators. Just as the the hastily applied frames did not enable early functional activity.
International Hoffmann Symposia had introduced the Original The US Military did not advocate external fixation for clinical
Hoffmann, annual courses and workshops in Freudenstadt, use in the Second World War even though several systems were
Germany provided a platform for advances in external fixation available. The thinking was that improperly applied frames
with the Hoffmann II. Stryker had purchased in 1996 the would cause damage. After the Haitian disaster and requirements
Osteo Group with its major manufacturing plant in Selzach, for military deployments at a distance, interest returned in the
Switzerland. Osteo was a manufacturer of nails, plates and use of a prepackaged, simple, large frame fixator for natural
fixators as well as prostheses. In 2004, with the acquisition of catastrophes and military deployments. The Hoffmann 3 was
Howmedica, Stryker moved the manufacture of external fixators designed in Selzach as a frame with interchangeable bars, a
to the plant in Selzach. To meet the requirements of active minimum of connectors, and simple instrumentation for field
trauma practice, modifications were made in the materials use (Figure 5). The Hoffmann 3 design engineers working for
for the connecting rods to make them MRI compatible. Again the manufacturer made sketches, produced prototypes and
the pressure of competition in the market dictated a further, then brought their new devices to surgeons not for input, but
more comprehensive, upgrade of the Hoffmann platform. rather for what was called ‘validation.’ In the US Drs. Andrew
Considerations were larger diameter connecting rods, reusability, Burgess, Gregory Osgood and David Seligson assembled fixators
reduction in the inventory of connectors, prepackaged fracture- in cadaver laboratories to prove or validate the designs. The next
specific modules, and interconnectivity with the Hoffmann II step was the submission of a 510k (approval based on preexisting
and Hoffmann Compact systems. design concepts) to the Food and Drug Administration on 27 July
The change in corporate structure brought about a different 2012 with the final agency clearance granted on 24 October 2012
process for design of the new fixator. Albin Lambotte, a Belgian, (within the 90 day allowed window). Since its introduction, the
was an expert woodworker who made violins, violas and cellos. Hoffmann 3 system has been shown to be successful particularly
He made models of his devices in wood for manufacturers to use as a ‘damage control’ frame for patients with significant
for fabrication [11]. The image from the past of Albin Lambotte polytrauma. The connecting rods are MRI conditional, which is
coming to the machine shop of Collin in Paris, taking off his an important new requirement as patients with severe injuries
jacket and sitting down to make a part to his own liking has are more likely to survive compared with in the past and are
now metamorphosed into a corporate document ‘chartering’ therefore more likely to require repeat advanced imaging.
the Hoffmann 3. In a large business entity at risk for shutdown
by regulatory agencies, many more hands have to view and Conclusion
shape the process of making new parts. Marketing must assess
the need, engineers prepare the drawings, legal must file the The design of the Hoffmann family of external fixators began
appropriate documentation, and compliance has to oversee the as a surgeon-driven concept and has recently been shaped
process. Traumatologists are now ‘consultants’: they are asked not only by industry, but also by marketing and regulatory
Downloaded for Anonymous User (n/a) at CK Mobile App Test from ClinicalKey.com by Elsevier on April 21, 2024.
For personal use only. No other uses without permission. Copyright ©2024. Elsevier Inc. All rights reserved.
S6 D. Seligson / Injury, Int. J. Care Injured 46 S3 (2015) S3–S6
Downloaded for Anonymous User (n/a) at CK Mobile App Test from ClinicalKey.com by Elsevier on April 21, 2024.
For personal use only. No other uses without permission. Copyright ©2024. Elsevier Inc. All rights reserved.