Genetics

Non-Modifiable
Age of Diagnosis

RISK FACTORS Dietary Management

Modifiable Medical Follow up

Compliance with treatment

Deficiency in enzymes galactose-1-phosphate

uridylyltransferase GALT

Accumulation of Galactose

Gastrointestinal system
Toxic Effects
(Galactitol and Galactose-1-phosphate

Vomiting & Diarrhea

Accumulation of Galactose in it's metabolites

Toxic Effects in brain

Central Nervous System
Distrupt Neurological Development

Development Delays & Intellectual Disabilities

Deficiency in enzymes galactose-1-phosphate

Galactosemia uridylyltransferase GALT

Accumulation of Galactose and it's metabolites in the

liver.
Digestive System

Disease process Toxic Effects on liver cells

Liver Enlargement

Deficiency in enzymes galactose-1-phosphate

uridylyltransferase GALT

Urinary System Accumulation of Galactose and it's metabolites in

kidney.

Kidney Failure

Galactitol Accumulation

Oxidative Stress

Formation of Advance Glycation End Process

Sensory System
Inflammation and Immune Response

Nutritional Deficiencies

Development of Cataracts