(a) all colourblind (b) all nomal visioned

PRINCIPLES OF INHERITANCE AND VARIATION one-half colourblind and one-half nonmal

(c)
(d) three-fourths colourblind and one-fourth nomal (204
1.
Which one of the following is an example of polygenic
inheritance? Both sickle cell anaemia and Huntington's chorea are
9.
(a) Skin colour in humans. diseases
(b) Flower colour in Mirabilis jalapa.
(a) virus related
diseases
(b) bacteria related
(c) Production of male honey bee. (c) congenital disorders
(d) Pod shape in garden pea. (2006) induced disorders.
(d) pollutant (209%
2. Phenotype of an organism is the result of 10. In the hexaploid wheat, the haploid (n) and basic (x) numher
nbers
(a) genotype and environment interactions of chromosomes are
(b) mutations and linkages 21 andx
(a) n =
21 and x
=
21 (b) n =
14
=

(c) cytoplasmic effects and nutrition 7 (d) 7 and x =21.

21 and x
=
n
(2007)
=

(d) environmental changes and sexual dimorphism. (c)n =

11. Inheritance of skin colour in humans is an example of

(2006)
3.
(a) point mutation (b) polygenic inheritance
How many different kinds of gametes will be produced by a (c) codominance (d) chromosomal aberration.
plant having the genotype AABbCC?
(a) Two (b) Three (2007
(c) Four (d) Nine. (2006) 12. In pea plants, yellow seeds are dominant to green. If a
In Mendel's heterozygous yellow seeded plant is, crossed with a green
experiments garden pea, round seed shape
with
seeded plant, what ratio of yellow and green seeded plants
(RR) was dominant over wrinkled seeds (rr), yellow cotyledon
(YY) was dominant over green cotyledon (yy). What are would you expect in Fl generation?
the expected phenotypes in the F2 generation of the cross (a) 9:1 (b) 1:3
RRYYx ryy? (c) 3:1 (d) 50: 50. (2007
(a) Round seeds with yellow cotyledons, and wrinkled seeds 13. A human male produces sperms the genotypes AB,
with Ab
with yellow cotyledons. aB, and ab pertaining to two diallelic characters in equal
(b) Only round seeds with green cotyledons. What is the corresponding genotype of this
(c) Only wrinkled seeds with yellow cotyledons.
proportions.
person?
(d) Only wrinkled seeds with green cotyledons. (2006) (a) AaBB (b) AABb
5. Test cross involves (c) AABB (d) AaBb. (2007)
(a) crossing between two genotypes with dominant trait 14. Which of the following conditions in humans is coTecly
one
(b) crossing between two genotypes with recessive trait matched with its chromosomal
(c) crossing between two F, hybrids abnormality/linkage?
(a) Erythroblastosis foetalis - X-linked.
(d) crossing the Fi hybrid with a double recessive genotype. (b) Down's syndrome 44 autosomes + X0.
(2006) (c) Klinefelter's syndrome - 44 autosomes + XXY.
6. Sickle cell anaemia has not been eliminated from the African (d) Colour blindness - Y-linked. (2008)
population because 15. Study the pedigree chart given below. What does it show
(a) it is controlled by dominant genes
(b) it is controlled by recessive genes
(c) it is not a fatal disease
(d) it provides immunity against malaria.
(2006)
7. Cri-du-chat syndrome in humans is caused by the
(a) trisomy of 21s chromosome (a) Inheritance
(b) fertilization of an XX egg by a normal Y-bearing sperm of a condition like phenylketonuria a
(c) loss of half of the short arm of chromosome 5 autosomal recessive trait.
(d) loss of half of the long arm of chromosome 5 (6) The pedigree chart is wrong as this is not poss Ssible.

(C) Inheritance of ke
like
a recessive sex-linked
(2006) disc
8. Ifa colourblind woman marries a normal visioned man, their hacmophilia.
sons will be
(d) Inheritance of a sex-linked inborm ror of
metabolism

2009
like phenylketonuria.
 Meticsa n dE V O l u t i o n

popularly known blood 463

The
most

It is named ABO and not

grouping is the
ABO
grouping.
ABC, because "0" (c) unaffected female
refers to having in it
(d) affected male.
overdominance of this type on the (2010)
al genes for A and B 24. In
(b) one antibody only either
anti -

A or anti types Antirrhinum, two plants th pink flowers were hybridized.

w
B on the
-

The
F plants produced red, pink and white flowers in the
RBCs
on RBCs
andB proportion of 1 red, 2 pink and l white. What could the
c) no antigens A genotype of the two plants used for be
(d) other antigens besides A and B on RBCs. hybridization? Red flower
colour is determined
Sickle-cell
anaemia is (2009) (a) r
by RR, and white by genes. m
17
(b) RR
caused by substitution of
by valine (c) Rr
beta globin chain of haemoglobin glutamic
acid in the (d) T.
(2010 M)
43. A cross inwhich an organism showing a dominant
b) caused by a change in a
single base pair of DNNA crossed with the recessive phenotype is
parent in order to know its genotype
(c)cha
characterized by elongated sickle like RBCs is called
with a
(a) monohybrid cross (b) back crc.s
nucleus
an autosomal dominant trait.
(c) test cross (d) dihybrid cross. (2010 M)
d) (2009) 26. Study the
Select the incorrect statement from the following pedigree chart of a certain family given below
and select the correct conclusion which can be drawn for the
al Galactosemia is an inborn error of metabolism.
character.
ASmall population size results in random genetic drift in
a population.
(c)Baldness is a sex-limited trait.

d) Linkage is an exception to the principle of independent (a) The female parent is heterozygous.
assortment in heredity.
(2009) (6) The parents could not have had a normal daughter for
19. Which one of the following cannot be explained on the basis this character.
of Mendel's law of dominance? (c) The trait under study could not be colour blindness.
(a) The discrete unit controlling a particular character is (4) The male parent is homozygous dominant. (2010 M)
called a factor.
27. When two unrelated individuals or lines are crossed, the
6) Out of one pair of factors one is dominant, and the other
performance of F, hybrid is often superior to both its parents.
recessive.
This phenomenon is called
()Alleles do not show any blending and both the characters (a) heterosis (b) transformation
recover as such in Fz generation. (2011)
()splicing (d) metamorphosis.
d) Factors occur in pairs. (2010) 28. Which one of the following conditions correctly describes the
20. The genotype of a plant showing the dominant phenotype can manner of determining the sex?
be determined by (a) Homozygous sex chromosomes (ZZ) determine female
(a) test cross (b) dihybrid cross sex in birds.

c)pedigree analysis (d) back cross. (2010) (b) X0 type of sex chromosomes determine male sex in

1.Selectthe correct statement from the ones given below with grasshopper.
(c) X0 condition in humans as found in Tumer's syndrome,
respect to dihybrid cross.
chromosomes show determines female sex.
(a) Tightly linked genes on the same
(d) Homozygous sex chromosomes (XX) produce male in
higher recombinations.
very show few Drosophila. (2011)
0)Genesfar apart on the same chromosome 29. Mutations can be induced with
recombinations. IAA
Genes loosely linked on the same chromosome show (a) infrared radiations (b)
(c) ethylene (d) gamma radiations. (2011)
similar recombinations.
the chromosome show very 30. Test cross in plants or in Drosophila involves crossing
ghtly linked genes on same
(2010)
few recombinations. (a) between two genotypes with recessive trait
lt between two Fl hybrids
controlled by the gene l. (b)
hae dgroups in humans are three difterent
(c) the F hybrid with a double recessive genotype
ree alleles A, B and i. Since there are
between two genotypes with dominant trait. (2011
-

How many (d) M)

are possible.
,SIX different genotypes
conditions of the zygotic cell
phenotypes occur? 31. Which one of the following
(a) Three would lead to the birth of a normal human female child?
(b) One
(c) Four (2010 P & M) (a) Two X chromosomes.
(d) Two.
chromosome.
. Which
and its
representation, (b) Only one Y
one of the
following symbols chromosome.
used in human pedigree:analysis is correct? (c) Only one X
(d) One Xand
one Y chromosome. (2011 M)
(a) mating between relatives
6) O unaffected male
 32. Fa generation in a Mendelian cross showed that both genotypiC 40. Which of the following statements is notnot true af
of .

that show 50% recombination frequency? two

and phenotypic ratios are same as 1: 2:1. t represents a case gene
of (a) The gene show independent assortment.
(a) co-dominance (b) dihybrid cross (b) If the genes are present on the same chromosom.
(c) monohybrid cross with complete dominance undergo more than one crossovers in every meiosis ihey
(d) monohybrid cross with incomplete dominance. (2012) (c) The genes may be on different chromosomes
33. A normal-vjsioned man whose father was colour-blind, marries (d) The genes are tightly linked.
whose father was also colour-blind. They have their (NEET 2013)
woman
afirst child as a daughter. Whatare the chances that this child
41. Fruit colour in squash is an example of
would be colour-blind? (a) recessive epistasis (b) dominant epistasis
(a) 100% (b) zero percent (c) complementary genes
(c) 25% (d) 50%. (2012) (d) inhibitory genes.
(2014)
34. A test cross is caried out to 42. A whose father was colour blind marries woman uhno
man a
(a) detemmine the genotype of a plant at F2 had a colour blind mother and normal father. What
percentage
(6) predict whether two traits are linked of male children of this couple will be colour blind?
(c) assess the number of alleles of a gene (a) 25% (b) 0%
(d) determine whether two species or varieties will breed (c) 50% (d) 75%
successfully. (2014)
(2012 M) 43. A human female with Turner's
35. Represented below is the inheritance syndrome
of a certain type (a) has 45 chromosomes with Xo
of trait in humans. Which one of pattem
the following conditions (b) has one additional X chromosome
could be an example of
this pattem? (c) exhibits male characters
(d) is able to produce children with normal husband.
Female Male
(2014)
mother Father 44. Alleles are
(a) different molecular forms of a gene
Daughter Son (b) heterozygotes
(c) different phenotype
(d) true breeding homozygotes. (2015, Cancelled)
(a) Phenylketonuria (b) Sickle cell anaemia 45.
(c) Haemophilia (d) Thalassemia.
Multiple alleles are
present
(2012 M) (a) the same locus of the
at
36. If both parents are carriers for thalassaemia, chromosome
which is an (6) on non-sister chromatids
autosomal recessive disorder, what are the chances of (c) on different chromosomes
pregnancy resulting in an affected child?
(d) at different loci on the
(a) 25% (b) 100%% same chromosome.
(c) No chance (d) 50% (2015, Cancelled)
(NEET 2013) 46. A man with
37.
blood group 'A' marries a woman with
Which idea is depicted by a cross in which the Fi generation Di
group B. What are all the
resembles both the parents? possible blood groups of ther
(a) Inheritance of one gene offsprings?
(a) A, B, AB and O (b) O only
(b) Codominance
(c) Incomplete dominance
(c) A and B
only (d) A, B and AB only
(d) Complete dominance (NEET 2013) (2015, Cancelld
47. How many
38. Select the incorect statement with regard to
haemophilia. pairs of contrasting characters in pea plants were

(a) It is a dominant disease.

studied by Mendel in his
b) A single protein involved in the clotting of blood is (a) Eight experiments?
(b) Seven
affected. (c) Five
(d) Six (2015, Cancelled
(c) It is a sex-linked disease. 48. An abnormal human baby with XXX*
(d) It is a recessive disease.
(NEET 2013) bom due to sex chromosomes
39. If two
persons with *AB' blood group marTy and have (a) fusion of two ova
and one sperm
sufficiently large number of children, these children could (b) fusion of two
and one ovum
be classified as 'A' blood
group: *AB' blood group (c) formation of sperms
blood group in 1: 2: I ratio. Modern B (d) formation of
abnormal sperms in the father
technique of
electrophoresis reveals presence of both *A' and 'B'protein
type
abnormal ova in the mother.
(2015, Cancelled
protcins in 'AB' blood group individuals. This in an example 49. A gene
of showing codominance has
(a) partial dominance (b) complete dominance (a) alleles that are
recessive to cach other
(c) codominance
(d) incomplete uurminance. (6) both alleles
independently expressed in the
(c) one allele dominant heterOE
(NEET 2013) on the other
(d) alleles tightly linked on 2015
the same chromosome.
 enetiesa n dE v o l u t i o n

classic
experiments onpea plants, Mendel 465
i n his did not use
(a) seed shape (b) flower position (a) X-linked (b) Autosomal
(c) s e e d c o l o u r (d) pod length. (c) Cytoplasmic
(2015) d) Y-linked. (2006)
hlind man marries a woman with O n e gene-one
normal sight who enzyme hypothesis was
(a) Beadle and Tatum (b) R. Franklinpostulated
1. Ac by
no history of colour blindness in her family. What is
the (c) Hershey and Chase (d) A. Garrod.
bability of their grandson being colour blind ? (2006)
(b) 0.25 60. One turn of
the helix in a B-form
(a) Nil
(d) 1 (a) 2 nm
DNA is approximately
( ) 0.5 (b) 20 nm
(2015) (c) 0.34 nm (d) 3.4 nm. (2006)
A pleiotropic gene
61. Which one of the
controls a trait only in combination with following pairs of codons is correctly
(a) another gene
A)controls mult1ple traits in an individual matched with their function or the signal for the particular
amino acid?
ie) is expressed only in primitive plants (a) AUG, ACG - Start/methionine
d) is a gene
evolved during Pliocene.
(2015) (6) UUA, UCA - Leucine
the following human
hnthe pedigree, the filled
symbols represent (C) GUU, GCU - Alanine
the affected individual: Identify the type of given pedigree. (d) UAG, UGA Stop. (2008)
62. Polysome is formed by
(a) a ribosome with several subunits
(b) ribosomes attached to each other in a linear arrangement
(c) several ribosomes attached to a single mRNA
(d) many ribosomes attached to a strand of endoplasmic
reticulum. (2008)

(i) OT-O 63. Which one of the following pairs of nitrogenous

nucleic acids, is wrongly matched with the category mentioned
bases of
against it?
(a) Guanine, Adenine - Purines
(v) (b) Adenine, Thymine - Purines

(a) Autosomal recessive (c) Thymine, Uracil - Pyrimdines

(6) X-linked dominant

(d) Uracil, Cytosine - Pyrimidines. (2008)
(c) Autosomal dominant 64. In the DNA molecule
(d) X-linked recessive (2015) (a) the proportion of adenine in relation to thymine varies

with the organism

SA. The term "linkage" was coined by
(b) there are two strands which run antiparallel-one in
(a) G. Mendel (b) W. Sutton 5'
(d) T. Boveri. (2015) S ' 3 direction and other in 3
(c)T.H.Morgan (c) the total amount of purine nucleotides and pyrimidine
nucleotides is not always equal
MOLECULAR BASIS OF INHERITANCE (d) there are two strands which run parallel in the 5' > 3'

is decided by the direction. (2008)

Aino acid sequence, in protein synthesis
65. What is not true for genetic code?
sequence of universal.
(b) RNA (a) It is nearly
(a) FRNA
(2006) (b) It is degenerate.
c) mRNA (d) cDNA
and mRNA (c) It is unambiguous.
between /RNA mRNAt is read in a non-contiguous
ich antibiotic inhibits interaction (d) A codon in
uring bacterial protein synthesis? fashion.
a) Tetracycline (b) Erythromycin (2009, 2010
(2006)
0) Neomycin (d) Streptomycin
Removal of introns and joining
the exons in a defined order
that 66.
called
transcription unit is
means
Antiparallel strand of a DNA molecule in a
(b) transformation
one strand turns clockwise (a) tailing
(d) splicing (2009)
(b) one strand urns anti-clockwise ends, (c)capping
at their of DNA was first demonstrated
() the phosphate strands, Semiconservative replication
two DNA
groups of 67.
share the same position are in
DNA
strands
Escherichia coli (b).Streptococcus pneumoniae
14) of two
the phosphate groups at the start
(2006) (a)
(c) Salmonella typhimurium
in
opposite position (pole). matermal (d) Drosophila melanogaster (2009)
AIn which mode uc of inheritance do you expect
more

uence among the offspring?

 76. The lac operon consists of
and discovered
08. Whose experiments cracked the DNA (a) four regulatory genes only
unequivocally that a genetic code is a "triplet"? b) one regulatory gene and three structural

(a) Hershey and Chase (b) Morgan and

Sturtevant (c) two regulatory genes and two structural genes
and Mathaei. (2009)
(c) Beadle and Tatum (d) Nirenberg (d) three regulatory enes and three structural genes
69. Point mutation involves
(a) change in single base pair 77. The 3' - 5' phosphodiester linkages inside a (2010y
(b) duplication chain serve to join
the other
polynucleoug
(c) deletion (a) one DNA strand with DNA strand
(d) insertion. (2009) (b) one nucleoside with another nucleoside
70. Select the two correct statements out of the four (i -1v) (c) one nucleotide with another nucleotide
statements given below about lac operon. (d) one nitrogenous base with pentose sugar.
and (2016 4
(1) Glucose or galactose may bind with the repressor 78. What are the structures called that give an appearance ae
inactivate it. on string' in the chromosomes when viewed under e
(ii) In the absence of lactose the repressor binds with the microscope?
electe
operator region. (a) Genes (b) Nucleotides
(ii) The Z-gene codes for permease. (c) Nucleosomes (d) Base pairs.
(201
(iv) This was elucidated by Francois Jacob and Jacques 79. The unequivocal proof of DNA as the genetic materalge
Monod. from the studies on a
The correct statements are (a) bacterium (b) fungus
(a) (i) and (ii) (b) i) and (ii) (d) bacterial virus.
(c)viroid
(c) (i) and (iv) (d) i) and (ii). (2010) (2011 M
71. Which one of the following palindromic base sequences in 80. In history of biology, human genome project led to th
DNA can be easily cut at about the middle by some particular development of
restriction enzyme? (a) biotechnology (b) biomonitoring
(a) 5 CACGTA (c) bioinformatics (d) biosystematics. (2011 M
3 CTCAGT 5
81. Removal of RNA polymerase Il from nucleoplasm wilaie
CGTTCG the synthesis of
(b) ATGGTA 5 (a) RNA (b) hnRNA

(c)
5 GAATTC (c) mRNA (d) RNA. (201
CTTAAG 82. Which one of the following i not a part of a transcnplue
GATATG unit in DNA?
(d) (2010) (b) A terminator
CTACTA- (a) The inducer
(c) A promoter (d) The structural gene. (201
72. Which one of the following does not follow the central dogma
83. Ribosomal RNA is actively synthesized in
of molecular biology?
(a) Pea (b) Mucor (a) lysosomes (b) nucleolus
(201
(c) Chlamydomonas (d) HIV. (2010) (c) nucleoplasm (d) ribosomes.
73. Which one of the following statements about the particular 84. If one strand of DNA has the nitrogenous base st
entity is true ? ATCTG, what would be the complementary RNA
(a) Centromere is found in animal cells, which produces aster sequence?
during cell division. (a) TTAGU (b) UAGAC
(b) The gene for producing insulin is present in every body (c) AACTG (d) ATCGU.
cell. in a
is formed of nucleotides.
85. Removal of introns and joining of exons
(c) Nucleosome
during transcription is called
(d) DNA consists of core of eight histones. (2010 M) (a) looping (b) inducing
75. In eukaryotic cell transcription, RNA splicing and RNA capping
(c) slicing (d) splicing.
take place inside the 86. Read the following four statements (A - D).
(a) ribosomes (b) nucleus
(A) In transcription, adenosine pairs with uracl
(c) dictyosomes (d) ER (2010 M)
75. The fruit fly Drosophila melanogaster was found to be very (B) Regulation of lac operon by repressor i
suitable for experimental verification of chromosomal theory positive regulation. approximately 50.000gentes

of inheritance by Morgan and his colleagues because (C) The human genome has sease.

(a) it reproduces parthenogenetically (D) Haemophilia is a sex-linked recessive u

right are

(b) single mating produces two young flies

a How any of the above statement
(c) smaller female is easily recognisable from larger male (a) Two (b) Three

(d) it completes life cycle in about two weeks. (2010 M) (c) Four (d) One.
ceneticsa n dE v o l u t i o n

467
Which enzyme wilI be produced in a cell in if there is a
nonsen m u t a t i o n in the lac Y gene? (a) G 17%, A 33%, T 33%
() Transacetylase (b) G 8.5%, A 50%, T 24.5%
Lactose pemease and transacetylase (c) G 34%, A 24.5%, T 24.5%
(c) B-galactosidase (d) Lactose permease (d) G 17%, A 16.5%, T 32.5%. (2015, Cancelled)
95. Which one of the following is not applicable to RNA?
(NEET 2013)
(a) Heterocyclic nitrogenous bases
The diagram shows an important concept in the genetic
implication of DN, Fill in the blanks A to C. (b) Chargaff's rule
A B (c) Complementary base pairing
"mRNA Protein Proposed by (d) 5' phosphoryl and 3' hydroxyl ends (2015)
DNA C
96. Balbiani rings are sites of
a)A-Transcription, B -Translation, C - Francis Crick (a) polysaccharide synthesis
(b) A - Translation, B - Extension, C - Rosalind Franklin
(b) RNA and protein synthesis
c A- Transcription, B - Replication, C James Watson
(c) lipid synthesis
d ) A- Translation, B - Transcription, C Ervin Chargaff (d) nucleotide synthesis. (2015)
(NEET 2013) 97. ldentify the correct order of organisation of genetic material
Which one of the following is wrongly matched? from largest to smallest.
9.
(a)Transcription Writing information from DNA to (a) Genome, chromosome, gene, nucleotide
tRNA. (b) Chromosome, genome, nucleotide, gene
(c) Chromosome, gene, genome, nucleotide
b)Translation Using information in m-RNA to make
(d) Genome, chromosome, nucleotide, gene (2015)
protein.
98. Satellite DNA is important because it
(c) Repressor protein - Binds to operator to sto enzyme
in all members of
synthesis. (a) does not code for proteins and is same

(d) Operon - Structural genes, operator and promoter. the population

(b) codes for enzymes needed for DNA replication
(2014) (c) codes for proteins needed in cell cycle
90. Transformation was discovered by (d) shows high degree of polymorphism in population and
(a) Meselson and Stahl (b) Hershey and Chase also the same degree of polymorphism in an individual,
(c) Grifith (d) Watson and Crick. (2014) which is heritable from parents to children. (2015)
91. Select the correct option.
Direction of RNA Direction of reading of the template
synthesis DNA strand
(a) 5'-3 ' -5'
5'-3'
(b) 3'- 5
(C) 5'-3 5-3
d) 3-5'
3-5 2014)
92. that involves
Tegulation governing lactose operon of E.coli
the lac I gene product is
Cgative and repressible because repressor protein
prevents transcription
Feedback inhibition because excess of B-galactosidase
can switch off
transcription be induced by
(c) and inducible because it can
rOSitive
lactose
protein prevens
gative and inducible because repressor
transcription. (2015. Cancelled)

another
to
ovement of from one linkage group
15 called
a gene
(a) translocation (6) crossing over
Cancelled
c) inversion duplication.
(2015,
(d)
the bases
urchin DNA, which is double stranded, theof
In 17%
other three
of
hown to be The percentages
cytosin DNA are
expected to be present in this