IVAN J. SAMARDJIEV 177 Broadway, Apt. C-1, Norwich, CT 06360 860-889-9429(h) . is135e770@westpost.

net

Senior Pharmaceutical Small Molecules X-ray Crystallography Associate Scientist with depth and functionality spanning solid-state/salt/polymorph selection, sol id-state characterization of DS and DP. Excellent crystallographic problem solvi ng skills and successful in collaborative, interdisciplinary environment. Extens ive knowledge across Material Science disciplines and provenability to integrate with and influence colleagues. Mentoring experience in X-ray crystallography. A dept at applying fundamental crystallographic approaches and collaborating to ac celerate compound development and innovating value added methodologies. Strong s cientific track record of refereed publications and internal presentations, as w ell as academic strategic alliances. Expertise in: * X-ray Single Crystal Analysisof Small Pharmaceutical Entities * X-ray Powder Diffraction Analysis * Patent and Legal Support via XRPD Analysis * Solid State Chemistry - crystallization and confirmation of new Salts/Polymorphs Forms * Variable Temperatures X-ray PowderDiffraction Methodologies * Capillary XRPD Methodologies * GMP XRPD Analysis * Advanced XRPD Technologies and Application * XRPD Data base and Support EXPERIENCE PFIZER, INC., GROTON, CT 1998 - 2010 Sr. Research Associate (1998 - 2010) Conducted over eight hundred small molecules X-ray Single Crystal Analysis and over fifty five thousand X-ray Powder Analysis from Discovery Leads to Phase II I compounds in a matrix resource environment. Successfully represented Material Science Dept. as a subject matter technical Powder X-ray Analysis expert in s upport of Legal Dept. Provided scientific and project support in solid-state cha racterization via X-ray crystallography. Proficient in performing GMP-XRPD. an alysis within SOP requirements. Broad interaction with Discovery, Chemical Devel opment, Formulation and Crystallization Technology groups. * Characterized the Crystalline Solid State of API through resolving molecula r properties via X-ray Single Crystal Analysis for Discovery and R&D colleagues (Evaluation, Mounting,collection Data Strategies, Integration, Direct Method of Refinement with issued Final Reports) * Specialized in growing Single Crystal specimen for confirming small volume molecular entits, Polymorphism, Hydration, Salt Formation of API in strategic al liance with Discovery and Material Science Departments. * Executed and coordinated X-ray Powder Analysis for all Research staff from Discovery to late stages of Development. * Represented Material Science in infringement Legal Case for Atorvastatin Cal cium as a Subject Matter Technical Expert in X-ray Powder Diffraction Analysis. * Developed and applied new methodologies in characterization of Solid State specimen through following techniques:Variable Temperature and Capillaries X-ray Powder Analysis, Semi-Quantitative Net Area algorithm experiments, Multiple-Wells X-ray diffraction assessment of Polymorphism, Hydra tion and Salt formation of the Solid State with Symyx(GADDS) High Through-output screening platform.

* Performed proficiently GMP-XRPD analysis within SOP requirements for AR&D colleagues * Maintained, coordinated and managed the Network database drive for X-ray P owder Diffraction and Single Crystal Analysis. * Trained Pfizer Inc. research staff within Material Science group in conduct ing X-ray Powder Diffraction Analysis EDUCATION Master of Science with Honors, Veterinary Biophysics (1990), The K.I. Skriabin Veterinary Academy - Moscow, Russia, Europe. Postgraduate Theses: Developing a method of using Ultrasonic techniques in determine resistance of different bio -membranes for diagnostic and genetic purposes. SPECIALTY TRAINING * Quality Assurance / Visual & Dimensional Inspection Cert. In Good Lab Practices; OSHA & HazMat Trained, 1995 * Analytical X-ray Systems - Window NT- Multitasking DIFFPLUS software for PXR D analysis, Pfizer Inc, Bruker AXS, Inc, Madison, WI, 1999 * Pharmaceutical Solids: Essential Knowledge and Advanced Concepts, Pfizer In c., SSCI Inc, 2000 * Crystallization and resolving molecular properties through X-ray Single Crys tal Analysis, Pfizer Inc., San Diego University, CA, 2005 REWARDS & MEMOS

* Pfizer Inc. Internal Personal Reward for going beyond expectations and res olve the Sol-X detector cooling line business critical technical problem, 2007 * Pfizer Inc. Internal Personal Reward for crystallizing and resolving molecu lar properties of highly challenging and business critical amorphous API throu gh Salt formation technique, 2010 * Pfizer Inc. Intellectual Properties Support Memo: " Investigation and vali dation of Net Area Algorithm Semi-Quantitative X-ray Powder Diffraction Analys is in determine relative ratios of API crystalline properties into amorphous pha se" PRESENTATIONS * Interesting cases of Single Crystal X-ray Analysis - Unique / Non-Unique mo lecule, Intra- molecular long chain phenomena refinement, crystallizing amorphou s API through Salt formation technique, Pfizer Inc, 2010 * Challenging cases of Single crystal X-ray Analysis - Incorporated impurities improve the crystalline uniformity, Dimebon SC growth - Twin or Large Cell dile mma, Pfizer Inc., 2009 * Pure Enantiomer vs. Intra-molecular Racemates with variable Occupancy ratio s, Pfizer Inc., 2008 * Growing SC and final refinement for Naproxen and Thiomicamine, University o f California-San Diego, 2007 * American Crystallographic Association meeting overview - Whole molecule diso rder, Supra-molecular engineering, SC growth techniques, Pfizer Inc., 2006 * Spectra Studio vs. PolySNAP - software Clustering algorithm validation, Pfiz er Inc., 2005

General Area Detector Diffraction System - a new dimensions in X-ray Powder Diffraction analysis -Multi-well screening and Capillary analysis, Pfizer Inc., 2004

PUBLICATIONS 2, 6-Diisopropylanilinium chloride. Samardjiev, Ivan J.; Samas, Brian. Pharm aceutical Sciences, Pfizer Global Research and Development, Groton, CT, USA. Acta Crystallographica, Section E: Structure Reports Online (2008) Mesophase Formation in Regioregular Poly (3-alkylthiophene) s Containing Long Ch ain Alkyl Groups. Wang, Yu; Archambault, Nadia; Belcher, Allison M.; Busse, Devin; Damon, David B.; Mills, Ashley; Riddle, Amanda E.; Samardjiev, Ivan J.; Lucht, Brett L.; Euler, William B. Department of Chemistry, University of Rho de Island, Kingston, RI, USA. Macromolecules (Washington, DC, United States) (2008) Molecular features crucial to the activity of pyrimidine benzamide-based thrombo poietin receptor agonists. Reiter, Lawrence A.; Jones, Christopher S.; Bris sette, William H.; McCurdy, Sandra P.; Abramov, Yuriy A.; Bordner, Jon; DiCapua, Frank M.; Munchhof, Michael J.; Rescek, Diane M.; Samardjiev, Ivan J.; Withka, Jane M. Pfizer Global Research & Development, Groton Laboratories, Groton, CT , USA. Bioorganic & Medicinal Chemistry Letters (2008) Solid-state characterization of NR2B selective N-methylaspartate (NMDA) antagoni st polymorphs. Kojima, Takashi; Sato, Morimichi; Omura, Atsushi; Kawai, Mak oto; Sakai, Mio; Matsuoka, Yoko; Murata, Yoshinori; Hattori, Kazunari; Sakemi, S hinichi; Bordner, Jon; Samardjiev, Ivan; Mano, Takashi. Pfizer Global Researc h and Development, Nagoya Laboratories, Pfizer Japan Inc., 5-2 Taketoyo, Aichi, Japan. International Journal of Pharmaceutics (2008) Determination of N-Heterocyclic Carbene (NHC) Steric sing the [(NHC) Ir (CO) 2Cl] System. Kelly, Roy udice, Simona; Scott, Natalie M.; Stevens, Edwin D.; van; Hoff, Carl D.; Cavallo, Luigi; Nolan, Steven P. University of New Orleans, New Orleans, LA, USA. and Electronic Parameters u A., III; Clavier, Herve; Gi Bordner, Jon; Samardjiev, I Department of Chemistry, Organometallics (2008)

Synthetic approaches to novel analogs of Tie-2 kinase inhibitors. Arcari, J oel T.; Chen, Michael J.; Hungerford, William; Patel, Nandini; Marx, Matthew A.; LaGreca, Susan; Martinez-Alsina, Luis; Wessel, Matthew; Anderson, Stephen; Bord ner, Jon; Borzillo, Gary; Clark, Tracey; Cohen, Bruce; Ewing, Marcus; Soderstrom , Catherine; Kakar, Shefali; Kanter, Aaron; Knauth, Lissie; Thompson, Carl; Tom, Norma; Samardjiev, Ivan; Vincent, Patrick W. Pfizer Global Research and Deve lopment, Pfizer Inc, Groton, CT, USA. Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, (2006) Twisted Amide Reduction under Wolff-Kishner Conditions: Synthesis of a Benzo-1AzaAdamantaneDerivative. Bashore, Crystal G.; Samardjiev, Ivan J.; Bordner, Jon; Coe, Jotham W. Pfizer Global Research and Development, Groton Laborator ies, Pfizer Inc., Groton, CT, USA. Journal of the American Chemical Society ( 2003) Preparation of a rigid aza-adamantane structure via Wolff-Kishner reduction of a twisted amide. Coe, Jotham W.; Bordner, Jon; Samardjiev, Ivan J.; Bashore, Crystal G. Neuroscience, Pfizer Global Research and Development, Groton, CT, USA. Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United St ates, August 26-30, (2001)

Member: American Crystallographic Association