European Federation For Medicinal Chemistry Societ Chimica Italiana - Divisione Di Chimica Farmaceutica

European School Of Medicinal Chemistry (XXXII Advanced Course of Medicinal Chemistry and "E. Duranti" National Seminar for PhD Students) Urbino, July 2-7 Campus Scientifico "E. Mattei"
Scientific Committee Carlo DE MICHELI - University of Milan Director Cosimo ALTOMARE - University of Bari Maria Laura BOLOGNESI - University of Bologna Romano DI FABIO - APTUIT s.r.l., Verona Gerhard F. ECKER - University of Wien Antonello MAI - University La Sapienza Rome Marco MOR - University of Parma Paolo PEVARELLO - Newron Pharmaceuticals, Bresso (Milan) Novella ROMANELLI - University of Florence Gilberto SPADONI - University of Urbino Carlo Bo Giampiero SPALLUTO - University of Trieste Organizing Committee Lucia BEDINI Giuseppe DIAMANTINI Americo SALVATORI Simone LUCARINI Dipartimento di Scienze Biomolecolari University of Urbino "Carlo Bo" Piazza Rinascimento, 6 61029 URBINO (PU) Italy tel. (+39) 0722-304551/303323 fax (+39) 0722-303313 E-mail: chimfarm@uniurb.it

The Organizers thank for their support:

Aptuit s.r.l., Verona (I) Chiesi Farmaceutici S.p.A., Parma (I) Corden Pharma S.p.A., Caponago (I) Domp S.p.A., LAquila (I) Explora Laboratories SA, Mendrisio (CH) Farmindustria Fondazione SEMM, Milan (I) Italian Biocatalysis Center, Pavia (I) Fabbrica Italiana Sintetici, Montecchio Maggiore (I) Sigma-tau, Pomezia (I) Spanish Society of Biotechnology, Madrid (E) Assessorato alla Cultura ed al Turismo della Citt di Urbino UniCredit, Agenzia di Urbino Universit degli Studi di Urbino Carlo Bo

MONDAY, JULY 2 15.00 18.30 19.00 22.00 Registration Poster Exhibition and Buffet Dinner

TUESDAY, JULY 3 9.00 9 .20 Opening of ESMEC 2012 Federico DA SETTIMO President of the Medicinal Chemistry Division of the Italian Chemical Society Gerhard ECKER Past President of the European Federation of Medicinal Chemistry Carlo DE MICHELI Director of the European PhD School of Medicinal Chemistry MALARIA AND NEGLECTED TROPICAL DISEASES Chairperson: 9.20 9 .30 9.30 10.15 10.15 11.00 11.00 11.30 11.30 12.15 Maria Laura BOLOGNESI, University of Bologna (I) Marco MOR, University of Parma (I) Introduction to the Session Ian GILBERT, University of Dundee (UK) Drug Discovery for Neglected Tropical Diseases Walter CABRI, Sigma-tau, Pomezia (I) A Journey from Artemisias Fields to Dihydroartemisinin/Piperaquine in Patients Coffee Break Elisabeth DAVIOUD-CHARVET, UMR CNRS, Strasburg (F) Killing Malarial Parasites with Redox-active 1,4-naphthoquinones Targeting Glutathione Reductase-catalyzed NADPH Reactionsdesign, Synthesis, Physicochemistry and Enzyme Kinetics Poster session 1 Chairperson: Gilberto SPADONI, University of Urbino (I) Lunch Ian GILBERT, University of Dundee (UK) Drug Discovery for Human African Trypanosomiasis Maria Paola COSTI, University of Modena-Reggio Emilia (I) Targeting the Biopterines Reduction Pathway for the Development of New Drugs against Leishmaniasis and Trypanosomiasis Meeting with PhD Students and Junior Researchers (an initiative by Farmindustria and Divisione di Chimica Farmaceutica della Societ Chimica Italiana) Current Challenges and Open Debates for the Pharmaceutical Industry

12.15 13.30 13.30 15.00 15.00 15.45 15.45 16.30

16.30 18.30

20.30 Dinner WEDNESDAY, JULY 4 FRAGMENT-BASED DRUG DISCOVERY: PRINCIPLES, APPROACHES AND TOOLS Chairperson: 9.00 9 .15 9.15 10.00 Cosimo ALTOMARE, University of Bari (I) Novella ROMANELLI University of Florence (I) Introduction to the Session Valerio BERDINI, Astex Pharmaceuticals, Cambridge (UK) Chemoinformatics and Modeling Approaches in Protein-targeted Library Design and Virtual Screening Ramn CAMPOS-OLIVAS, Spanish National Cancer Research Centre (CNIO), Madrid NMR Spectroscopic Techniques in Fragment-based Drug Discovery 10.45 11.15 11.15 12.00 12.00 13.30 13.30 15.00 Coffee Break Rocco CALIANDRO, Institute of Crystallography, CNR, Bari (I) Protein Crystallography and Fragment-based Drug Design Poster Session 2 Chairperson: Gilberto SPADONI, University of Urbino (I) Lunch

10.00 10.45 (E)

15.00 15.45 15.45 17.45 20.30

Luca SARTORI, Drug Discovery Unit, European Institute of Oncology, Milan (I) Discovery of Novel Hsp90 Inhibitors using a Fragment-based Screening Approach Workshop Dinner

THURSDAY, JULY 5 ADVENTURES IN NATURAL PRODUCTS SYNTHESIS AND BIOTECHNOLOGICAL METHODOLOGIES Chairperson: 9.00 9 .15 9.15 10.00 10.00 10.45 10.45 11.15 11.15 12.00 12.00 12.45 12.45 15.00 15.00 15.45 15.45 18.00 20.30 FRIDAY, JULY 6 Chairperson: 9.00 9.15 9.15 10.00 10.00 10.45 10.45 11.15 11.15 12.00 12.00 12.45 12.45 14.45 14.45 18.00 Chairperson: 18.00 20.30 HOT TOPICS Antonello MAI, University of Rome La Sapienza (I) Paolo PEVARELLO, Newron Pharmaceuticals, Milan (I) Introduction to the Session Klaus MOHR, University of Bonn (D) Allosteric structure-function-studies in a small molecule G-protein-coupled Fabio RANCATI, Chiesi Farmaceutici S.p.A., Parma (I) Drug Design for Pulmonary Delivery Coffee Break A. GANESAN, University of East Anglia, Norwich (UK) Lead Discovery by Virtual Screening: NAADP as a Case Study Marco GIORGIO, Italian Institute of Oncology, Milan (I) Diet, Cancer and Aging: from Nutraceutics to Nutragenimics Lunch Presentation and Discussion of Selected Posters Gloria CRISTALLI, University of Camerino (I) Concluding Remarks Carlo DE MICHELI University of Milan (I) ESMEC Director Gala Dinner Romano DI FABIO - Aptuit Verona (I) Giampiero SPALLUTO University of Trieste (I) Introduction to the Session Steven LEY, University of Cambridge (UK) Challenges and Opportunities in Natural Product Synthesis Giovanni APPENDINO, University of Piemonte Orientale, Novara (I) Polyphenolics: the Blackbox of Organic Synthesis Coffee Break Steven LEY, University of Cambridge (UK) New Tools for Molecule Makers and Applications in Natural Product Synthesis Andres ALCANTARA, University Complutense, Madrid (E) White Biotechnology and Green Solvents in Biocatalysis Lunch Riccardo MOTTERLE, Fabbrica Italiana Sintetici, Montecchio Maggiore (I) Biocatalytic Synthesis of Active Pharmaceutical Ingredients: from Lab to Industrial Scale Workshop Dinner

SATURDAY, JULY 7 Leaving of Participants