I am 60 years old, but I want to be

always young in heart and healthy.

Physiclly, mentally, social living in
the meaningful condition for
waiting the hopeful something for
tomorrow

SCIENCE :
1. THEORITICAL SCIENCE
a. Nomothetic theoritical science
b. Descriptive theoritical science
2. APPLIED SCIENCE
a. Normative applied science
b. Teleologic applied science
c. Comprehensive applied science
d. Finalistic applied science
e. Complementary science
3. PROFESSIONALISM
a. Subjective cummulative value based
b. market oriented based
c. divergensive mechanism
d. competition and survival

Clinical Interventional
Radiology and the Aging
Process
Soetjipto
Mei 1996
( Department of Radiology, School of
Medicine, UNS University / dr Muwardi
Teaching Hospital
Surakarta )
Presented in national congress of Radiology 1996

The medicine postulation

1. BIO-ORGANIC POSTULATION
Until 1950
2. BIOCELLULAR POSTULATION
Until 2000
After all, it was still to be primadona in
Indonesia now adays
3, BIOM OLECULAR POSTULATION

in the beginning of the third

mellinneum

Bio-organic postulate
Functional equilibrium
Interdependency
Feedback mechanism

organo
n

The cell
BIOMOLECULARY POSTULATE
Exothermic biochemistry
Mt-DNA

No repairy
Mt-DNA

1. oxidant
2. Energy
150.000

Endothermic
biochemistry

Decreasing energy
1.
2.
3.
4.
5.

Aging process
Mets
Auto-immune disease
Functional disbalancing
Apoptosis

C-DNA

nucleus
17.p.23

The
revolution
1.
2.
3.
4.

information

The human development index

Biocellular to biomolecular postulate
How to win the competition
How to have the safety, the security
and the prosperity of the applied
science and its professionalism
The philosophy of existentialism in
applied science is one of the many
ways to solve

How is about Radiology in the

effort to overcome
the challenging future ?

depending upon T
1 modality vs multiple modality
SWOT
One of the many ways is the matters
of meaning given by the Radiologist
in the Clinical Interventional
Radiology

Exothermic biochemistry

Mt-DNA

No repairy
Mt-DNA

1. oxidant
2. Energy
150.000

Endothermic
biochemistry

Decreasing energy
1.
2.
3.
4.
5.

The cell

Aging process
Mets
Auto-immune disease
Functionasl disbalancing
Apoptosis

C-DNA

nucleus
17.p.23

LIFE IS INDEED THE BIOCHEMISTRY MECHANISM

PROCESS

Aging process is really a disease

1. The genetic Mt-DNA vs the c-DNA

2. The target organ :

a. nutrition given cell ( 22.p.72 and

22.p.92 genes) vs the endothelial

response

b. fibroprotein & collagen vs GAG

c. Auto-immune Ag formation.

d. Metabolic syndrome&Organ dysfunction

3. Ecosystems influenced variables ( oxydant,

foetal & inheritance program, nutrition,

life style / corpus amygdale )

1.METALOPROTEINASE

a. Angiopoetin for capillary bed

b. vasculopoetin for vascularity

THE
CELL
22.P.72
22.P.92

2. METALOPROTEINASE II
For nutritional cytocine
3. METALOPROTEINASE III
For extracellulary matrix (ECM)
a. For the frame of ECM ( collagen,
elastin,
fibroprotein
b. For the basic ontent of spaces inter
the
frame ( mucopolysacharide fluid )
c. For the substances supporting the
living cell
( GAG, laminin, nutrition, mineral,
aminoglican, hyalin, etc )
4. METALOPROTEINASE IV

THE INTERDEPENDENCY
THE CELL
GAP-JUNCTION
200 ANGSTROM
RECEPTOR c-AMP
RECEPTOR c-GMP

THE ACTIN MECHNISM

THE INTEGRIN
THE COMPONENT

MECHANISM

THE
ECM

ENDOTHELIAL DYSFUNCTION

At-1R

Endothelin
Ar-2R
Adhesion mol

NO
Prostacyclin
component

C-Amp
Ca+
Oligopeptide
Oligosachaeride

C-DNA

A-Gmp
Ca+
Oligopeptide
Oligosacharide

Endothelium
Nutrition receptor

At-1R
A
t

At-2R

Endothel
ia

The vascular with its

t
general nutritional
substance
cytokine
Nutrition for the cell
22.p.72

The cell

The fourth fundamental

physical law of nature :
interdependency

nucleus
mitochondria

Extracellulary matrix

Atheroscclerotic plaque

Ig-G anti CMV

Ig-G anti Mitochondria +

Double contour aortitis

Proteinuri 500 mg %
Creatinin 3,2 mg %
Ig-G antimitochondria +

HbA1c 10
Ig-G anti mitochondria +
Ig-G anti chlamydea +

double contour aortitis

atheroma

Cholesterol total 350 mg %

LDL 250 mg %
HDL 25 mg %
uric acid 10 mg %
tensi 180/60

granulomatous
wall
atherosclerotic
plaque

atheroma

Kadar gula darah sewaktu 425mg %

HBA1c 17 Chol:HDL=7 LDL:HDL=5
Tensi 170/110 trombosit 400.000/cc,
fibrinogen 450 mg / dl

granulomatous wall

atherosclerotic plaque dan atheroma

cephalgia khronik, badan lemah sekali, Hb 10 gr %,

HBA1-c 8 HS-CRP 8 chol:HDL 7 LDL:HDL 4,5
Ig-G anti mitochondria Endogenic anti-oksidan
drop

Lemah sekali, sulit jalan, reflex pateler

normal,anorexia Head Ct Scan :
chronic ischemic brain HS-CRP 15,
Ig-G anti mitochondria + HBA1-c 7,5
uric acid 8 mg % creatinin 1,3 mg %
chol : HDL 7, LDL : HDL 4,5

atheroma dan
atherosclerotic
plaque

granulomatous wall
kadar gula darah sewaktu 425 mg %
Chol:HDL= 7 LDL:HDL 5
Ig-G anti CMV -. Ig-G anti
chlamydea -

I am satisfied,
.and
Matur Nuwun