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Pharmacokinetics: Sutomo Tanzil Dept - of Pharmacology, Faculty of Medicine, Sriwijaya University
Pharmacokinetics: Sutomo Tanzil Dept - of Pharmacology, Faculty of Medicine, Sriwijaya University
Sutomo Tanzil
Dept.of Pharmacology, Faculty of
Medicine, Sriwijaya University
Lipid solubility
pH & ionization
Not selective, no energy required,
not saturable, cannot be inhibited
pH partition & ion trapping
Most drugs across cell membrane
by this transfer.
Carrier-mediated Transport(CMT)
Oral/Enteral administration
Drug metabolism
Inhibition of P450
Induction of P450
Enzyme inducers: ethanol,rifampicin,
carbamazepine,increase the activity of
microsomal oxidase and conjugating
systems when administered repeatedly
Glomerular filtration
Tubular secretion
Saturation kinetics