PREPARATION

OF ACETANILIDE
SYNTHESIS
OF

ORGANIC
COMPOUND
BONIFACIO.
CUBAR. ENGRESO.
GROUP
I
PEREZ

One must be
able to:

1. Synthesize acetanilide by
reacting aniline with acetic
OBJECTIVE
anhydride;
2. Test for
the purity of the
S:
synthesize product
through
its boiling point.

Acetanilide
or also called
It is used as an analgesic
Acetanil,
as
(pain
reliever
drug).
N-phenylacetamide
or
Acetanilid
But being
replaced by
INTRODUCTION
is an odorless solid organic
Aspirin, because Aniline is
compound.
suspected to be
carcinogenic.

Chemical Reaction:
+

+
Aniline

Acetic
anhydride

Mole ratio: 1:1

Acetanilide

Acetic
acid

Reaction
Mechanism:

A. Synthesis of
B. Melting point
Acetanilide
Weigh 0.15-0.20 mL of
aniline. Place in a test
tube

Allow to
completely dry.
Weigh.

+ 5.00 mL dist. water.

+ 20 drops acetic
anhydride

Collect the crystals

using a Buchner
funnel.

METHODOLO
GY

Stir for 5 mins.

until solid forms

+ 5.00 mL water and

heat test tube in hot
water bath

Cool for 3-5 minutes.

Chill in an ice bath.

Table 1. Percentage yield of

Table 2. Melting point of acetanilide.
acetanilide.
Volume
(mL)
0.60
of Acetic Anhydride
Melting
Point
Trials
Actual
Percent
Volume ofTheoretical
Aniline (mL)
1.00
Error
0.4485
Mass 1
of Acetanilide (actual
yield, g)

112 C
114 C
2
116 C

RESULTS &
DISCUSSION

Mass of Acetanilide (theoretical yield,

g)
3
113 C
Percentage yield (%)

Mean

113.7 C

0.8900

50.40%

0.2632 %

Determining the Limiting

Reagent:

Mass Acetic anhydride:

CALCULATIONS

Mass Acetic
Moles
Aceticanhydride:
anhydride:

Moles Acetic anhydride:

CALCULATIONS
Determining the Limiting

Reagent:

Mass Aniline:

Moles Aniline:
Aniline:
Mass

Moles Aniline:

Table 3. Moles of used compound.

Compound
Mass
Moles
Acetic
anhydride
Aniline
Aniline is the limiting reagent.

Determining the % Yield: