SIgA (Secretory IgA)

RM. Agung Pranata

 80% of all plasma cells

are located in the
intestinal lamina propria
and together produce
more IgA than all other
Ig isotypes combined.
Class switching to IgA is
regulated by TGF-

Secretory component (SC) prevents proteolytic

damage to secretory IgA in the harsh luminal
microenvironment

transported to the
apical surface. The
portion of the
pIgR attached to the
Fc region of IgA is
then enzymatically
cleaved and stays
bound to dimeric IgA
as secretory
component.

Secretory IgA has several functions

at epithelial surfaces?

Role of IgA in host defense against viruses. It can

either block entry into epithelium, or directly
inactivate virus. Because of its relatively low
proinflammatory potential relative to IgG, it is suited
for clearance of infection with minimal tissue
damage.

IgA and mucosal host

defense against
bacteria. IgA can act
to prevent bacterial
adhesion to
epithelium, a key first
step in infection.
Secretory component
is believed to provide
protection from
bacterial proteases.
IgA2 is more protease
resistant than IgA1.

QUESTION AND ANSWER PERIOD