NSTEMI

OlehST: ELEVATION
Restu Muh.
Adam C111
(NON
MYOCARDIAL
12 299
INFARCTION)

Definition
Acute myocardial infarction (AMI) is
an irreversible necrosis of heart
muscle due to prolonged ischemia,
which is suddenly happened.
Imbalance in oxygen supply and
demand, which is most often caused
by plaque rupture with thrombus
formation in a coronary vessel,
resulting an acute reduction of
blood supply to a portion of the
myocardium.

Risk Factors
Modifiable
o Smoking
o Hypertension
o Obesity
o Diabetes Mellitus
o Dyslipidemia
o Low HDL < 40
o Elevated LDL / TG

Non Modifiable
o Gender and age:
- male after age 45 y.o
- female after age 55 y.o
o Family History in first
degree
relative > 55 y.o for
male/ 65 y.o for female

VASCULARISATION

PATHOPHYSIOLOGY
American Heart Association: http://watchlearnlive.heart.org

American Heart Association: http://watchlearnlive.heart.org

American Heart Association: http://watchlearnlive.heart.org

American Heart Association: http://watchlearnlive.heart.org

Biochemical marker for detection of

myocardial necrosis
First rise
after AMI

Peak after
AMI

Return to
normal

CK-MB

4h

24 h

72 h

Myoglobin

2h

6-8 h

24 h

Troponin T

4h

24 - 48 h

5 21 d

Troponin I

3-4 h

24 36 h

5 14 d

Biomarkers

Management

Oxford Handbook of Clinical Medicine 6th Edition

Thank You