the Extracellular Matrix Two main ways in which animal cells are bound together Four functional classes of cell junctions in animal tissues A summary of the various cell junctions found in a vertebrate epithelial cell, classified according to their primary functions Transmembrane adhesion proteins link the cytoskeleton to extracellular structures Cadherins mediate Ca2+-dependent cell-cell adhesion in all animals Cadherins mediate homophilic adhesion