GENERAL PATHOLOGY

(MLS 207)

GROUP FIVE (5)

CHEMICAL MEDIATORS
OF HEALING
1
GROUP 5 CHEMICAL MEDIATORS OF HEALING
 GROUP MEMBERS
NAMES INDEX NUMBERS
JOHN AKAMBOI AVEA PS/MLB/16/0068
PRINCE MARFO GYABI PS/MLB/16/ 0005
ACKAH MIRIAM ELOSM PS/MLB/16/OO86
ANINAKWAH YEBOAH VERA PS/MLB/16/0095
JOSEPH OPOKU NKRUMAH PS/MLB/16/0077
BRIGHT AFRAME ADJABENG PS/MLB/16/0032
PRICILLA SEYRAM TSETSE PS/MLB/16/0059
ISAAC AMAPOFO DUODU PS/MLB/16/0041
ASAMOAH YAW ISAAC PS/MLB/16/0050
EBENZER PS/MLB/16/000

GROUP 5 CHEMICAL MEDIATORS OF HEALING 2

 TOPIC OVERVIEW

DEFINITION OF HEALING

PHASE OF HEALING
INFLAMMATION PHASE
FIBROBLASTIC PHASE
MATURATION AND REMODELING PHASE
GROUP 5 CHEMICAL MEDIATORS OF HEALING 3
CONTI. OF TOPIC OVERVIEW
CHEMICAL MEDIATORS
NAME OF CHEMICAL MEDIATORS
SYMBOLS OF CHEMICAL MEDIATORS
SOURCE OF CHEMICAL MEDIATORS
FUNCTION OF CHEMICAL MEDIATORS
WITHIN PHASE OF HEALING
GROUP 5 CHEMICAL MEDIATORS OF HEALING 4
 CONTI. OF TOPIC OVERVIEW

CLINICAL SIGNIFICANCE

REFERENCE

GROUP 5 CHEMICAL MEDIATORS OF HEALING 5

DEFINATION OF HEALING

THE PROCESS OF RETURING TO

HEALTH; THE RESTORATION OF
STRICTURE AND FUNCTION OF INJURED
OR DISEASED TISSUE

GROUP 5 CHEMICAL MEDIATORS OF HEALING 6

PHASE OF HEALING
FIBROBLASTIC PHASE
THERE IS THE PROLIFERATION AND REGENERATION ACTIVITIES OF
THE CELLS LEADING TO SCAR FORMATION
PERIOD OF SCAR FORMATION IS IN THE FIBROBLASTIC PHASE
SIGNS AND SYMTOMS OF INFLAMMATION SUBDUES

GROUP 5 CHEMICAL MEDIATORS OF HEALING 7

CONTI. FIBROBLASTIC PHASE

BREAKDOWN OF FIBROSIN TO FORM GRANULATION TISSUE;

FIBROBLAST, COLLAGEN AND CAPPILARIES
THE NUMBER OF FIBROBLAST DIMINISHES TO SIGNAL THE
BEGINNING OF MATURATION PHASE

GROUP 5 CHEMICAL MEDIATORS OF HEALING 8

MATURATION AND REMODELLING PHASE

RE-ALLIGNMENT OF COLLAGEN

DECREASE IN TYPE III COLLAGEN FIBRES AND

CAPILLARIES

GROUP 5 CHEMICAL MEDIATORS OF HEALING 9

CONTI. MATURATION AND REMODELLING
PHASE
INCREASE IN TYPE I COLLAGEN FIBRES; INCREASE IN TENSILE
STRENGHT
TISSUES ASSUMES A NORMAL APPEARANCE AMD FUNCTION
AFTER SOMETIME A FIRM , STRONG, CONTRACTED AND NON
VASCULAR SCAR EXIST

GROUP 5 CHEMICAL MEDIATORS OF HEALING 10

 PROCESS OF HEALING

GROUP 5 CHEMICAL MEDIATORS OF HEALING 11

CONTI. OF HEALING PROCESS

GROUP 5 CHEMICAL MEDIATORS OF HEALING 12

SUMMARY NOTE ON HEALING

GROUP 5 CHEMICAL MEDIATORS OF HEALING 13

CHEMICAL MEDIATOR OF HEALING

ANY MESSENGER THAT ACTS ON BLOOD VESSELS,

INFLAMMATORY CELLS, OR OTHER CELLS TO CONTRIBUTE TO
AN HEALING.

GROUP 5 CHEMICAL MEDIATORS OF HEALING 14

CHEMICAL MEDIATORS OF HEALING
CYTOKINE SYMBOL SOURCE FUNCTIONS

1. EPIDERMAL GROWTH EGF PLATELETS, MITOGENIC FOR KERATINOCYTES

FACTOR MACROPHAGES, AND FIBROBLASTS; STIMULATES
SALIVA, URINE, MILK, KERATINOCYTE MIGRATION AND
PLASMA GRANULATION TISSUE FORMATION

GROUP 5 CHEMICAL MEDIATORS OF HEALING 15

CONTI. CHEMICAL MEDIATORS OF HEALING
CYTOKINE SYMBLOS SOURCE FUNCTION
HEPATOCYTE HGF MESENCHYMAL ENHANCES PROLIFERATION OF
GROWTH CELLS EPITHELIAL AND ENDOTHELIAL CELLS,
FACTOR/SCATTER AND OF HEPATOCYTES; INCREASES
FACTOR CELL MOTILITY
VASCULAR VEGF MESENCHYMAL INCREASES VASCULAR PERMEABILITY;
ENDOTHELIAL CELL CELLS MITOGENIC FOR ENDOTHELIAL CELLS
GROWTH
FACTOR
(ISOFORMS A, B,
C, D)
2. TGF-A MACROPHAGES, T SIMILAR TO EGF; STIMULATES
TRANSFORMING LYMPHOCYTES, REPLICATION OF HEPATOCYTES AND
GROWTH FACTOR KERATINOCYTES, CERTAIN EPITHELIAL CELLS
ALPHA AND MANY
TISSUES

GROUP 5 CHEMICAL MEDIATORS OF HEALING 16

 CONTI. OF CHEMICAL MEDIATORS OF HEALING
CYTOKINE SYMBLOS SOURCE FUNCTION
KERATINOCYTE KGF FIBROBLASTS STIMULATES KERATINOCYTE
GROWTH FACTOR MIGRATION, PROLIFERATION, AND
(ALSO DIFFERENTIATION
CALLED FGF-7)

PLATELET-DERIVED PDGF PLATELETS, CHEMOTACTIC FOR PMNS,

GROWTH FACTOR MACROPHAGES, MACROPHAGES, FIBROBLASTS, AND
(ISOFORMS A, B, C, ENDOTHELIAL SMOOTH MUSCLE CELLS; ACTIVATES
D) CELLS, PMNS, MACROPHAGES, AND
KERATINOCYTES, FIBROBLASTS; MYOGENIC FOR
SMOOTH MUSCLE FIBROBLASTS, ENDOTHELIAL CELLS, AND
CELLS SMOOTH MUSCLE CELLS; STIMULATES
PRODUCTION OF MMPS, FIBRONECTIN,
AND HA; STIMULATES
ANGIOGENESIS AND WOUND
CONTRACTION; REMODELLING; INHIBITS
GROUP 5 CHEMICAL MEDIATORS OF HEALING
PLATELET AGGREGATION; 17

REGULATES INTEGRIN EXPRESSION

 CONTI. OF CHEMICAL MEDIATORS OF HEALING
CYTOKINE SYMBLOS SOURCE FUNCTION
INSULIN-LIKE IGF-1 MACROPHAGES, STIMULATES SYNTHESIS OF SULPHATED
GROWTH FACTOR- FIBROBLASTS AND PROTEOGLYCANS, COLLAGEN,
1 OTHER CELLS KERATINOCYTE MIGRATION, AND
FIBROBLAST PROLIFERATION; ENDOCRINE
EFFECTS SIMILAR TO GROWTH HORMONE
TUMOUR NECROSIS TNF MACROPHAGES, ACTIVATES MACROPHAGES; REGULATES
FACTOR MAST CELLS, T OTHER CYTOKINES; MULTIPLE FUNCTIONS
LYMPHOCYTES

INTERLEUKINES IL-1, ETC. MACROPHAGES, MANY FUNCTIONS. SOME EXAMPLES:

MAST CELLS, CHEMOTACTIC FOR PMNS (IL-1) AND
KRATINOCYTES, FIBROBLASTS (IL-4),
LYMPHOCYTES, STIMULATION OF MMP-1 SYNTHESIS (IL-1),
AND MANY ANGIOGENESIS (IL-8), TIMP SYNTHESIS (IL-
TISSUES 6);
REGULATION OF OTHER CYTOKINES

GROUP 5 CHEMICAL MEDIATORS OF HEALING 18

 CONTI. OF CHEMICAL MEDIATORS OF HEALING
CYTOKINE SYMBLOS SOURCE FUNCTION

TRANSFORMING TGF-B PLATELETS, T CHEMOTACTIC FOR PMNS, MACROPHAGES,

GROWTH FACTOR LYMPHOCYTES, LYMPHOCYTES, FIBROBLASTS, AND SMOOTH
BETA MACROPHAGES, MUSCLE
(ISOFORMS 1, 2, ENDOTHELIAL CELLS; STIMULATES TIMP SYNTHESIS,
3); OTHER CELLS, KERATINOCYTE MIGRATION, ANGIOGENESIS,
MEMBERS OF THE KERATINOCYTES, AND FIBROPLASIA;
FAMILY ARE BMP SMOOTH INHIBITS PRODUCTION OF MMPS AND
AND ACTIVIN MUSCLE CELLS, KERATINOCYTE PROLIFERATION; REGULATES
FIBROBLASTS INTEGRIN
EXPRESSION AND OTHER CYTOKINES;
INDUCES TGF-B PRODUCTION
FIBROBLAST FGF MACROPHAGES, CHEMOTACTIC FOR FIBROBLASTS;
GROWTH MAST CELLS, T MITOGENIC FOR FIBROBLASTS AND
FACTOR-1 LYMPHOCYTES, KERATINOCYTES; STIMULATES
(ACIDIC), -2 ENDOTHELIAL KERATINOCYTE MIGRATION, ANGIOGENESIS,
(BASIC) AND CELLS, FAM WOUND CONTRACTION AND MATRIX
FAMILY FIBROBLASTS, AND DEPOSITION
MANY TISSUES

GROUP 5 CHEMICAL MEDIATORS OF HEALING 19

CONTI. OF CHEMICAL MEDIATORS OF HEALING

CYTOKINE SYMBLOS SOURCE FUNCTION

INTERFERONS IFN-A, ETC. LYMPHOCYTE ACTIVATES MACROPHAGES;

S AND INHIBITS FIBROBLAST
FIBROBLASTS PROLIFERATION AND SYNTHESIS
OF MMPS;
REGULATES OTHER CYTOKINES

GROUP 5 CHEMICAL MEDIATORS OF HEALING 20

VIDEO OF MEDIATORS IN ACTION

GROUP 5 CHEMICAL MEDIATORS OF HEALING 21