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1.4.4.2 - Biologi OKsidasi 2
1.4.4.2 - Biologi OKsidasi 2
(OXIDATIVE STRESS)
Free radical
3 levels
FR scavengers
trace elements
drugs and compounds influence to FR metabolism
Superoxid dismutase
• haptoglobin
• hemopexin
• albumin
Low-molecule endogennous antioxidats I
Ascorbate (vitamin C) Alfa-tocopherol a vitamin E
collagen synthesis localise in membranes
dopamine to epinephrine produces hydroperoxides,
conversion which are changes by
reduction agent GSHPx
Fe absorption
antioxidant = reduction O2 · -
OH ·, ROO·, HO2 ·
tocopheryl radical
regeneration
prooxidant
Ascorbic acid and its metabolites
Low-molecule endogennous antioxidats II
ubiquinone (coenzyme Q)
electron carrier in respisratory chain
co-operates with tocopheryl
bilirubin
flavonoids
Trace elements influence to FR
metabolism
Selenium
influence to vitamin E resorption, part of
selenoproteins
of Se = insufficient immun. respons,
erytrocytes hemolysis, methemoglobin synthesis
Zinc
cell membrane stabilisation
Fe antagonist
Oxidative damage to lipid
Damage Sequel