Professional Documents
Culture Documents
11 - Hemostasis & Blood Coagulation
11 - Hemostasis & Blood Coagulation
Coagulation
BY
IDIONGO O. UMOH
DEFENSE MECHANISM
By the property of agglutination, platelets encircle the
foreign bodies and destroy them
I Fibrinogen
II Prothrombin
IV Ca++
HMWK,
XII XIIa prekalikrein
VIIIa, platelets
phospholipids,
XI XIa Ca++
Thrombin IX IXa
X Xa
V,
phospholipids,
Prothrombin
Ca++ Platelets
activator
phospholipids,
Ca++
Prothrombin Thrombin
Activated factor X
Combine with tissue phospholipids,
platelets phospholipids, factor V, Ca++
To form the complex known as prothrombin
activator
Platelet Prothrombin
phospholipids, activator
Ca++
Prothrombin Thrombin
2 antiplasmin
Inhibit plasminogen
activation
Fibrin Soluble fibrin
Slows formation of
plasmin
Spontaneous bleeding.
Prolonged bleeding due to cuts, tooth
extraction and surgery.
Hemorrhage in gastrointestinal and
urinary tracts.
Bleeding in joints followed by swelling
and pain
Appearance of blood in urine