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Lipid Modifications of Cells Molecule and Lipid Signaling, Lipid-Mediated Localization of Signaling Proteins
Lipid Modifications of Cells Molecule and Lipid Signaling, Lipid-Mediated Localization of Signaling Proteins
N-myristoylation
Prenylation
S-Palmitoylation
N-myristoylation
Methionylpeptidase
N-MYRISTOYLATION
Prenylation
• Farnesylation
• Geranylgeranylation
C15
C20
Prenylation
FARNESYLATION
S-Palmitoylation
S-Palmitoylation
S-Palmitoylation
Lipid raft
1. Non-raft membrane
2. Lipid raft
3. Lipid raft associated transmembrane protein
4. Non-raft membrane protein
5. Glycosylation modifications (on glycoproteins and glycolipids)
6. GPI-anchored protein
7. Cholesterol
8. Glycolipid
Lipid Raft
Contain twice the amount of cholesterol
The hydrophobic chains of the lipids contained in the rafts are more saturated
and tightly packed than the surrounding bilayer.
Detergent resistance
IgE signaling
APC signaling
EGF signaling