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• Respon Terapi
- Retikulosit naik 2-3 hari dan mencapai puncak pada hari 7-8.
- Hb naik 2-3 g/dl setiap 2 minggu
- Neuropati membaik, tetapi kerusakan medulla spinalis biasanya ireversibel[9]
PROGNOSIS
• Prognosis dari Anemia Megaloblastik Defiesiensi B12 adalah baik apabila
etiologinya dapat diketahui dan diberikan penanganan yang tepat.
DAFTAR PUSTAKA
• AA A, AH A, AP S, FH A. Prevalence of pernicious anemia in patients with
macrocytic anemia and low serum B12 . Pakistan Journal of Medical Sciences.
2014;30(6):1218-1222. doi:10.12669/pjms.306.5413.
• Bakta IM. 2006. Hematologi Klinik Ringkas. Jakarta: Penerbit Buku Kedokteran
EGC.
• Fernández-Bañares F, Monzón H, Forné M. A short review of malabsorption and
anemia. World Journal of Gastroenterology : WJG. 2009;15(37):4644-4652.
doi:10.3748/wjg.15.4644.
• Hannibal L, Lysne V, Bjørke-Monsen A-L, et al. Biomarkers and Algorithms for the
Diagnosis of Vitamin B12 Deficiency. Frontiers in Molecular Biosciences. 2016;3:27.
doi:10.3389/fmolb.2016.00027.
• Health Quality Ontario. Vitamin B12 and Cognitive Function: An Evidence-Based
Analysis. Ontario Health Technology Assessment Series. 2013;13(23):1-45.
DAFTAR PUSTAKA
• Kaferle J, Strzoda CE. Evaluation of Macrocytosis. American Family Physician.
2009: Feb 1;79(3):203-208.
• Lim C-H, Kim SW, Kim WC, et al. Anemia after gastrectomy for early gastric
cancer: Long-term follow-up observational study. World Journal of
Gastroenterology : WJG. 2012;18(42):6114-6119.
doi:10.3748/wjg.v18.i42.6114.
• Rodrigues V, Dias A, Brito MJ, Galvão I, Ferreira GC. Severe megaloblastic
anaemia in an infant. BMJ Case Reports. 2011;2011:bcr0220113835.
doi:10.1136/bcr.02.2011.3835.
• Sudoyo AW, Setiyohadi B, Alwi I, Simadibrata M, Setiati S. 2014. Buku Ajar
Ilmu Penyakit Dalam. Edisi Kelima. Jilid II. Jakarta: InternaPublishing.
• Schick P. 2017. Megaloblastic Anemia. Medscape. Retrieved 9/05/2018
from https://emedicine.medscape.com/article/204066-overview#a6
THANK YOU
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