This document summarizes the clinical presentation of multiple sclerosis. It describes four categories of the disease course and lists common signs and symptoms affecting various parts of the body. A diagnosis of relapsing-remitting multiple sclerosis can be made if a patient experiences two or more clinical attacks and MRI reveals lesions in two or more areas of the central nervous system, or a new lesion appears on MRI following a clinical episode. Laboratory tests of cerebrospinal fluid may show increased protein and immunoglobulin levels as well as antibodies to myelin basic protein.
This document summarizes the clinical presentation of multiple sclerosis. It describes four categories of the disease course and lists common signs and symptoms affecting various parts of the body. A diagnosis of relapsing-remitting multiple sclerosis can be made if a patient experiences two or more clinical attacks and MRI reveals lesions in two or more areas of the central nervous system, or a new lesion appears on MRI following a clinical episode. Laboratory tests of cerebrospinal fluid may show increased protein and immunoglobulin levels as well as antibodies to myelin basic protein.
This document summarizes the clinical presentation of multiple sclerosis. It describes four categories of the disease course and lists common signs and symptoms affecting various parts of the body. A diagnosis of relapsing-remitting multiple sclerosis can be made if a patient experiences two or more clinical attacks and MRI reveals lesions in two or more areas of the central nervous system, or a new lesion appears on MRI following a clinical episode. Laboratory tests of cerebrospinal fluid may show increased protein and immunoglobulin levels as well as antibodies to myelin basic protein.
Four categories have been used to Blindness describe the course of the disease: relapsing-remitting, primary progressive, Nystagmus and double vision secondary progressive, and progressive- relapsing. incoordination, spasticity, difficulty in walking, loss of balance and vertigo, coordination or weakness, First clinical signs of multiple sclerosis tremor or paralysis of a limb - Begin in young adulthood. - According to which region of the CNS is involved (motor or bowel and bladder incontinence sensory region) and what degree of disruption occurs in the myelin sheath
Imprecise speech or tremor
loss of touch, pain, temperature,
and proprioception
Fatigue and worsening fatigue in
the afternoon • Laboratory findings Made on the basis of information derived from the history, clinical examination, CSF, sensory evoked potential, and magnetic resonance imaging (MRI) performed over time.
MRI scans typically reveal multiple
two or more clinical hypodense demyelinated regions attacks occur in a patient (plaques) in white matter, usually near who has two or more the ventricles, brainstem cerebellum, affected CNS locations and optic nerves Diagnose of The CSF shows signs of low-grade MRI lesion newly appears Relapsing – remitting after a second clinical inflammation multiple sclerosis attack Protein and immunoglobulin levels are increased in 80% to 90% of patients after one clinical attack Antibodies to myelin basic protein when a new MRI lesion detected in the CSF appears The conduction response to visual stimuli or somatosensory evoked stimuli is usually delayed and altered in amplitude