Treatment of Pediatric Chronic

Kidney Disease-Mineral and Bone

Disorder
 Pediatric Chronic Kidney Disease–
Mineral and Bone Disorder
• CKD-MBD describes a broader clinical
syndrome that develops as a systemic disorder
of mineral and bone metabolism due to CKD,
which is manifested by abnormalities in bone
and mineral metabolism and/or extra-skeletal
calcification
Anak dengan CKD dapat mengalami :
1. Gangguan pertumbuhan
2. bone-specific morbidity secondary to renal
osteodystrophy, including fractures and bone
deformities.
Pathogenesis of CKD-MBD
 Therapeutic approaches in CKD-MBD
• Current pediatric renal osteodystrophy
treatment paradigms aim to minimize
complications to the growing skeleton and
prevent the extraskeletal calcifications that
define CKD-MBD.
• Therapeutic approaches focus on the
treatment of hyperphosphatemia and
secondary hyperparathyroidism.
• Hyperphosphatemia
• Secondary hyperparathyroidism
• Nutritional vitamin D supplementation
• Fibroblast growth factor 23