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Tutik Harjianti,SpPD,K-HOM
SubDiv.of Hematology & Medical Oncology
Dept.of Internal Medicine, Medical Faculty
Hasanuddin University
Sub Topics :
I. Introducton of D.I.C.
II. Trigger Mechanism of D.I.C.
III. Etiology of D.I.C.
IV. Clinical pictures of D.I.C.
V. Diagnosis of D.I.C.
VI. Management of D.I.C.
VII. Prognosis of D.I.C.
I. Introduction :
DIC
Disseminated : widespread
Intravascular : inside the bloodline
Coagulation : blood clot production
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Physiology of blood circulation :
Overstimulation of coagulation
suppresion of control mechanism
DIC.
Important Clue :
1. Decreased of fibrinogen
2. Decreased of platelet
3. Decreased of coagulation factors
4. Exaggerated of fibrinolysis
II. TRIGGER MECHANISM OF D.I.C :
1 TUMOR RELEASE OF
Tissue TRAUMA “TISSUE FACTOR” DIC
TissueNECROSIS INTO CIRCULATION
2 ENDOTOXIN ACTIVATION of
GRAM NEGATIVE BACT. COAGULATION DIC
CASCADE
(F XII)
EXPRESSION OF
TISSUE FACTOR
in MONOCYTE & ACCELERATION of COAG RX
ENDOTHELIAL
cells
III. ETIOLOGY of D.I.C.
- Oftenly undiagnosed
- Unexplained bleeding usually lead the
clinician to think about D.I.C.
IV. Clinical pictures of DIC :
1. Abnormal coagulation
2. Bleeding (more often)
- can be found at any place
- spontaneous bleeding
- at the site of wound, ooze, cath etc.
Coagulation disorders in DIC .
Subacute DIC
Oftenly found in cancer patients
Thrombosis in superficial & profundal
veins (DVT), commonly recurrent
V. Diagnosis of D.I.C.
Depends on :
1. severity of coagulation reaction
2. amount of bleeding
3. etiology of DIC (malignancy etc)
Action of Plasmin :