PROPYLTHIOURACIL ORAL MEDICATION THAT IS USED TO MANAGE HYPERTHYROIDISM

USES ADVERSE EFFECTS

MOA:
1) Graves disease 1) Maculopapular rash
1) Inhibition of peroxidase reaction
2) Toxic nodular goiter
3)Drug of choice for
Block iodine organification hyperthyroidism in first trimester of 2) hepatotoxicity
pregnancy and lactation
2)Blocks iodotyrosine coupling 3) agranulocytosis

DOSAGE
3)Inhibit peripheral deiodination of FORMULATIONS
T3 and T4 50-150 mg TDS followed by
25-50 mg BD-TDS for
maintenance
TOXICITY

CONTRAINDICATIONS
HEPATOTOXICITY
Bone marrow suppression and
hepatic disease ,
pregnancy