NANOSTRUTURE HYBRID MATERIALS FOR BIO MEDICAL

APPLICATIONS

Presentation
By

Tarundeep Kaur Lamba

Enrollment No: A4450017049
M.Sc. Applied Physics (2017-2019)

Supervisor: Dr. Rajesh Faculty Guide: Dr. Gautam Singh

Co-Supervisor: Dr. A. M. Biradar Department Physics,
National Physical Laboratory, Amity institute of Applied Sciences,
Dr. K. S. Krishanan Marg, New Amity University, Noida, U.P.
Delhi-110012.
 Nano materials

• Size range of 1 to 100nm

• They can be isotropic (spherical) and
anisotropic (rod, tube, etc.) in shape Type
• Greater surface area to volume ratio than their
bulk counterparts
• Tremendous driving force for diffusion
especially at elevated temperature

Shape
Why liquid crystals

• Short range positional order but long range

orientational order and can be used to amplify and
transude the surface binding events into optical
outputs that can be easily observed even with
naked eye.
• Label free detection with high sensitivity and without
the requirement of complex instruments and even
the need of electrical power ,making them
sufficiently simple and well suited for performing
2 experiments.
 APPLICATIONS OF
LIQUID CRYSTAL

Liquid crystal drug Liquid crystal laser

delivery

Liquid crystal
thermometers

Liquid crystal drug lenses Liquid crystal sensor

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 What are liquid
crystals ?

Anisotropy in dielectric and

Viscosity, optical properties, optical
flow like liquid birefringence like in solid

Chemical basis Geometrical structure

 Thermotropic  Rod shape
 Lyotropic  Bent Core shape
 Chromonic  Disc shape
 Hybrid

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 Various phases of thermotropic liquid crystal (rod shape)
director (n)

or

Chiral Nematic (N*)

Isotropic (Iso) Nematic (N)

I am Jayden Smith
I am here because I love to give presentations.
5 Solid Smectic C (SmC) Smectic A (SmA)
 Ferroelectric liquid
crystals

Molecular arrangement
in Sm C phase

Chirality

Molecular arrangement in Sm C* phase Smectic layers

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 SAMPLE PREPARATION (PHOTOLITHOGRAPHY)

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 Liquid Crystal Biosensor

The liquid crystal based biosensor have been studied for the quantitative detection of cardiac biomarker,
troponin I (cTnI) in phosphate buffer for the diagnosis of cardiac vascular diseases.

Schematic diagram ITC complex detection of different concentration

Liquid crystal sample cell

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 INSTRUMENTS

WAYNE KERR 6540 A

INSTEC STC 200 HOT STAGE OPTICAL POLARISING JULABO F-25 TEMPERATURE
9 MICROSCOPE CONTROLLER
 Crossed-polarising optical micrographs Dielectric study

Result
Optical images shows
that the optical
contrast of the liquid
crystal alignment is
different for different
concentration of
troponin I

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 DIELECTRIC STUDY
Collective Process

 Goldstone mode
 Soft mode
 P-UHM mode

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 CHARACTERISATION OF CELL
ANTIPARRALEL CELL d=8μm 90° ALIGNMENT CELL d=8μm 45° ALIGNMENT CELL d=8μm

Different oscillating voltage at room temperature

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 Different temperatures, at 700mV Different temperatures, at 700mV Different bias with 500mV oscillating
oscillating voltage and zero bias. oscillating voltage and 1V bias. voltage at room temperature.
ANTIPARRALEL CELL

90° ALIGNMENT CELL

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 OPTICAL TEXTURES UNDER CROSSED POLARISING MICROSCOPE

90° twisted structure thick cell(~40μm)

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 Conclusion and Future
Scope

• Understanding of the optical observation and dielectric relaxation processes provides useful
information for the selection of material for a particular device application.
• In FLC material, p-UHM mode is newly discovered and still needs to be explored for more
practical applications.
• In our LC-biosensors, there is a change in the LC alignment due to different concentrations
of ITC complex. The effect of different ITC complex concentrations on the real and imaginary
parts of dielectric permittivity need to be understood.
• The bio-molecule detection could be explored by using ferroelectric liquid crystals (FLCs).
We believe that FLCs would be more useful in sensing applications than conventional
nematic liquid crystals.
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 References

[1] A.Choudhary,A.Bawa,Rajesh ,S.P Singh and A.M. Biradar ,Phy Rev E 95,0627032(2017)
[2] L.K.Gangwar ,A Bawa A.Choudhary S.P.Singh Rajesh,A.M.Biradar ,Phy Rev 97 ,062707(2018)
[3] M.Tyagi,A.Chandran, T.Joshi, J.Prakash, V. V. Agrawal,and A. M. Biradar Appl. Phys. Lett. 104,154104
(2014).

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